Results 121 to 130 of about 11,887 (214)

Sphingosine Kinase 2 Regulates Aryl Hydrocarbon Receptor Nuclear Translocation and Target Gene Activation

Advanced Science
AbstractSphingolipids play vital roles in metabolism and regulation. Previously, the aryl hydrocarbon receptor (AHR), a ligand‐activated transcription factor, was reported to directly regulate ceramide synthesis genes by binding to their promoters. Herein, sphingosine kinase 2 (SPHK2), responsible for producing sphingosine‐1‐phosphate (S1P), was found ...
Shigetoshi Yokoyama, Imhoi Koo, Daisuke Aibara, Yuan Tian, Iain A. Murray, Stephanie L. Collins, Denise M. Coslo, Mari Kono, Jeffrey M. Peters, Richard L. Proia, Frank J. Gonzalez, Gary H. Perdew, Andrew D. Patterson   +12 more
openaire   +3 more sources

Quinone-mediated induction of cytochrome P450 1A1 in HepG2 cells through increased interaction of aryl hydrocarbon receptor with aryl hydrocarbon receptor nuclear translocator

The Journal of Toxicological Sciences, 2016
While it has long been believed that benzenes and naphthalenes are unable to activate the aryl hydrocarbon receptor (AhR) because they are poor ligands, we recently reported that these quinoid metabolites upregulated cytochrome P450 1A1 (CYP1A1) in Hepa1c1c7 cells (Abiko et al., 2015).
Yumi, Abiko, Fang-Yu, Lin, Hsinyu, Lee, Alvaro, Puga, Yoshito, Kumagai   +4 more
openaire   +3 more sources

Expression of Zebra Fish Aromatase cyp19a and cyp19b Genes in Response to the Ligands of Estrogen Receptor and Aryl Hydrocarbon Receptor [PDF]

, 2017
Many endocrine-disrupting chemicals act via estrogen receptor (ER) or aryl hydrocarbon receptor (AhR). To investigate the interference between ER and AhR, we studied the effects of 17β-estradiol (E2) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the ...
Brion, Francois, Cheshenko, Ksenia, Eggen, Rik I.L., Hinfray, Nathalie, Kah, Olivier, Le Page, Yann, Pakdel, Farzad, Segner, Helmut   +7 more
core  

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway

Cell Death and Disease
Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays a crucial role in the development of various tumors.
Wenqing Zou, Yiming Lei, Cong Ding, Hongjun Xiao, Shunxin Wang, Shaobo Liang, Weijie Luo, Zhiqing Long, Shiwei He, Qingjie Li, Han Qiao, Na Liu, Yanping Mao   +12 more
doaj   +1 more source

Expression of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in human spermatozoa.

Medical science monitor : international medical journal of experimental and clinical research, 2004
The objective of this study was to determine if human spermatozoa express AHR (dioxin receptor) and ARNT and if mRNA levels for these transcription factors correlate with sperm concentration, motility or morphology.This was a case-controlled cohort study in which AHR and ARNT mRNA levels in subjects with normal and abnormal semen analysis were compared.
Omid, Khorram, Mark, Garthwaite, Jeffrey, Jones, Thaddeus, Golos   +3 more
openaire   +1 more source

Targeting ARNT attenuates chemoresistance through destabilizing p38α-MAPK signaling in glioblastoma

Cell Death and Disease
Glioblastoma (GBM) is the most aggressive and lethal brain tumor in adults. This study aimed to investigate the functional significance of aryl hydrocarbon receptor nuclear translocator (ARNT) in the pathogenesis of GBM.
Wahafu Alafate, Gen Lv, Jiantao Zheng, Haiping Cai, Wei Wu, Yong Yang, Shichao Du, Dong Zhou, Peng Wang   +8 more
doaj   +1 more source

Aryl hydrocarbon receptor nuclear translocator promotes the proliferation and invasion of clear cell renal cell carcinoma cells potentially by affecting the glycolytic pathway. [PDF]

Oncol Lett, 2020
Zhao Y, Han F, Zhang X, Zhou C, Huang D.
europepmc   +1 more source

Aryl Hydrocarbon Receptor Nuclear Translocator [PDF]

, 2020
openaire   +1 more source

Expression of Concern: Downregulated brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 inhibits osteogenesis of BMSCs through p53 in type 2 diabetes mellitus. [PDF]

Biol Open, 2020
Mao X, Li X, Hu W, Hao S, Yuan Y, Guan L, Guo B.   +6 more
europepmc   +1 more source

Aryl Hydrocarbon Receptor Nuclear Translocator 2 [PDF]

, 2020
openaire   +1 more source