Results 101 to 110 of about 11,887 (214)

A viable hypomorphic Arnt2 mutation causes hyperphagic obesity, diabetes and hepatic steatosis

Disease Models & Mechanisms, 2018
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) is a member of the basic helix-loop-helix/PER-ARNT-SIM (bHLH/PAS) transcription factor family. ARNT2 heterodimerizes with several members of the family, including single-minded homolog-1 (SIM1) and
Emre E. Turer, Miguel San Miguel, Kuan-wen Wang, William McAlpine, Feiya Ou, Xiaohong Li, Miao Tang, Zhao Zang, Jianhui Wang, Braden Hayse, Bret Evers, Xiaoming Zhan, Jamie Russell, Bruce Beutler   +13 more
doaj   +1 more source

Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study [PDF]

, 2006
Background Dioxins and related compounds are suspected of causing neurological disruption in human and experimental animal offspring following perinatal exposure during development and growth.
Eiichi Akahoshi, Seiko Yoshimura, Mitsuko Ishihara-Sugano, KM Burbach, M Ema, DW Nebert, M Machala, O Hankinson, YZ Gu, BN Fukunaga, PB Jones, A Fujisawa-Sehara, LA Neuhold, PM Fernandez-Salguero, K Sogawa, SK Kolluri, T Matikainen, SL Schantz, BW Seo, M Kakeyama, T Kainu, P Huang, BD Abbott, BD Abbott, MA Williamson, RP Castleberry, G Wu, J Diaz-Nido, M Cortes-Canteli, K Mitsui, T Baba, A Kobayashi, AJ Mao, A Hargreaves, X Li, F Causeret, I Ahmed, MD Kim, J O'Brien, EM Larson, MJ White, Y Tillet, A Kastner, KS Kim, J Wagner, O Saucedo-Cardenas, B Joseph, LS Birnbaum, JA Walisser, BA Jensen, LL Allan, K Shiromizu, TM Matikainen, R Thiel, M Kakeyama, E Herlenius, MP Viveros, A Kazlauskas, JR Petrulis, S Ahmed, KT Park, W Dong, T Ohtsuka, JS Thomsen, P Castella   +64 more
core   +1 more source

A Global Transcriptomic Analysis Reveals Body Weight‐Specific Molecular Responses to Chronic Orange Juice Consumption in Healthy Individuals

Molecular Nutrition &Food Research, Volume 69, Issue 24, December 2025.
This study aimed to investigate the molecular pathways involved in the health benefits of chronic orange juice (OJ) consumption through global transcriptomic approach in peripheral blood mononuclear cells (PBMCs). Healthy volunteers consumed 500 mL of OJ daily for 60 days.
Layanne Nascimento Fraga, Dragan Milenkovic, Isabella de Araújo Esteves Duarte, Saivageethi Nuthikattu, Camille Perella Coutinho, Franco Maria Lajolo, Neuza Mariko Aymoto Hassimotto   +6 more
wiley   +1 more source

Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex

Nature Communications
The aryl hydrocarbon receptor (AHR) possesses an extraordinary capacity to sense and respond to a wide range of small-molecule ligands, ranging from polycyclic aromatic hydrocarbons to endogenous compounds.
Xiaotong Diao, Qinghong Shang, Mengqi Guo, Yubin Huang, Meina Zhang, Xiaoyu Chen, Yinping Liang, Xiangnan Sun, Fan Zhou, Jingjing Zhuang, Shuang-Jiang Liu, Christoph F. A. Vogel, Fraydoon Rastinejad, Dalei Wu   +13 more
doaj   +1 more source

Genome-wide survey and expression analysis of the bHLH-PAS genes in the amphioxus Branchiostoma floridae reveal both conserved and diverged expression patterns between cephalochordates and vertebrates [PDF]

, 2014
BACKGROUND: The bHLH-PAS transcription factors are found in both protostomes and deuterostomes. They are involved in many developmental and physiological processes, including regional differentiation of the central nervous system, tube-formation, hypoxia
Jr-Kai Yu, Kun-Lung Li, Tsai-Ming Lu
core   +1 more source

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection, Volume 3, Issue 4, Page 386-395, December 2025.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
wiley   +1 more source

Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion

Stem Cell Research, 2017
Culture conditions used for the expansion of hematopoietic stem and progenitor cells (HSCs and HPCs, collectively HSPCs) should ideally favor the self renewal of long-term HSCs.
Carlo Stephan Jackson, Chrisna Durandt, Ilse Janse van Rensburg, Vincent Praloran, Philippe Brunet de la Grange, Michael Sean Pepper   +5 more
doaj   +1 more source

Studies on gender-specific disruption of bone tissue homeostasis by dioxins [PDF]

, 2010
Dioxins are widespread environmental pollutants, known to cause immunosuppression, developmental and reproductive defects, as well as cancer. The toxic effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR, also referred to as the ...
Wejheden, Carolina
core   +1 more source

ARNT2 controls prefrontal somatostatin interneurons mediating affective empathy

Cell Reports
Summary: Empathy, crucial for social interaction, is impaired across various neuropsychiatric conditions. However, the genetic and neural underpinnings of empathy variability remain elusive.
Jiye Choi, Seungmoon Jung, Jieun Kim, Dahm So, Arie Kim, Sowon Kim, Sungjoon Choi, Eunsu Yoo, Jee Yeon Kim, Yoon Cheol Jang, Hyoin Lee, Jeongyeon Kim, Hee-Sup Shin, Sehyun Chae, Sehoon Keum   +14 more
doaj   +1 more source

Identification of a novel functional deletion variant in the 5'-UTR of the DJ-1 gene [PDF]

, 2009
Background DJ-1 forms part of the neuronal cellular defence mechanism against oxidative insults, due to its ability to undergo self-oxidation. Oxidative stress has been implicated in the pathogenesis of central nervous system damage in different ...
Rowena J Keyser, Lize van der Merwe, Mauritz Venter, Craig Kinnear, Louise Warnich, Jonathan Carr, Soraya Bardien, D Nagakubo, Q Huai, V Bonifati, RH Kim, A Wagenfeld, PM Abou-Sleiman, V Bonifati, V Bader, L Zhang, N Lev, T Taira, MT Lin, T Kinumi, T Yokota, J Choi, R Bandopadhyay, N Lev, RM Canet-Avilés, T Taira, J Eerola, CM Morris, G Annesi, WR Gibb, CL Wilson, P Pocar, GG Loots, MS Denison, SP Rivera, H Choi, H Choi, CA da Costa, DX Liu, GU Höglinger, K Larsen   +40 more
core   +1 more source