Results 91 to 100 of about 11,887 (214)

A comprehensive contribution of genes for aryl hydrocarbon receptor signaling pathway to hypertension susceptibility [PDF]

, 2017
The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in the molecular basis of essential hypertension ...
Bulgakovaa, I. V., Bushueva, O. Y., Churnosov, M. I., Freidin, M. B., Polonikov, A. V.   +4 more
core  

Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome. [PDF]

, 2015
BACKGROUND: Autism Spectrum Conditions (ASC) are neurodevelopmental conditions characterized by difficulties in communication and social interaction, alongside unusually repetitive behaviours and narrow interests.
Baron-Cohen, Simon, Chakrabarti, Bhismadev, Di Napoli, Agnese, Warrier, Varun   +3 more
core   +3 more sources

Vitamin C Alleviates Oxidative Stress in Silver Carp (Hypophthalmichthys molitrix) Fingerlings Exposed to Toxicity Induced by Temephos and Buprofezin

Aquaculture Research, Volume 2026, Issue 1, 2026.
Context Organophosphates and chitin synthesis inhibitor pesticides pose a significant indirect threat to fish populations, necessitating effective remedial measures. Objective Supplementation with vitamin C (Vit C) in fish feed as a counteracting strategy to mitigate pesticides effect was explored in silver carp (Hypophthalmichthys molitrix ...
Sumaira Hassan, Irfan Zia Qureshi, Modhi O. Alotaibi, Mitesh Patel, Mohd Adnan, Nawaf Alshammari, Shakira Ghazanfar   +6 more
wiley   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, Volume 12, Issue 48, December 29, 2025.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications. [PDF]

, 2009
peer reviewedaudience: researcher, professionalGermline mutations of the aryl hydrocarbon receptor (AHR)-interacting protein (AIP) gene confer a predisposition to pituitary adenomas (PA), usually in the setting of familial isolated PA. To provide further
Jaffrain-Rea, Marie-Lise, Angelini, M., Gargano, D., Tichomirowa, M. A., Daly, Adrian, Vanbellinghen, Jean-François, D'Innocenzo, E., Barlier, Anne, Giangaspero, F., Esposito, Vincenzina, Ventura, L., Arcella, A., Theodoropoulou, M., Naves, Luciana Ansaneli, Fajardo, C., Zacharieva, S., Rohmer, V., Brue, T., Gulino, A., Cantore, G., Alesse, E., Beckers, Albert   +21 more
core   +1 more source

Physiological Differences Underlying Divergent Hypoxia Responses and Altitude Adaptations in Humans, Rats and Mice

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Despite many physiological similarities, mice, rats and humans respond remarkably differently to hypoxia. In line with their high‐altitude phylogeographic history, mice are physiologically well equipped to deal better with high‐altitude hypoxia than humans, while the low‐land origin of rats may be associated with a particularly high vulnerability to ...
Johannes Burtscher, Robert T. Mallet, Anupam Sah, Max Gassmann, Martin Burtscher, Rodrigo Iturriaga   +5 more
wiley   +1 more source

Compendium of TCDD-mediated transcriptomic response datasets in mammalian model systems [PDF]

, 2017
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is the most potent congener of the dioxin class of environmental contaminants. Exposure to TCDD causes a wide range of toxic outcomes, ranging from chloracne to acute lethality.
Boutros, Paul C., Chong, Lauren C., Harding, Nicholas J., Houlahan, Kathleen E., Lee, Jamie, Lensu, Sanna, Lindén, Jere, Moffat, Ivy D., Okey, Allan B., Pang, Renee, Pohjanvirta, Raimo, Prokopec, Stephenie D., P’ng, Christine, Smith, Ashley B., Sun, Ren X., Watson, John D., Wu, Alexander H., Yao, Cindy Q.   +17 more
core   +1 more source

AMPK‐Dependent Epigenetic Regulation of Metabolism Mediates the Anti‐Cancer Action of Pterostilbene in Hepatocellular Carcinoma

Molecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
This study investigates the anti‐cancer effects of pterostilbene (PTS), a naturally occurring dietary phytoestrogen, in a rat model of hepatocellular carcinoma (HCC) induced by a choline‐deficient L‐amino acid‐defined (CDAA) diet. Supplementation with PTS significantly reduces liver steatosis and tumor formation.
Cayla Boycott, Megan Beetch, Katarzyna Lubecka‐Gajewska, Benjamin S. Ramsey, Sandra Torregrosa‐Allen, Bennett D. Elzey, Abigail Cox, Nadia Atallah Lanman, Aline de Conti, Min Li, Mario Ferruzzi, Igor Pogribny, Barbara Stefanska   +12 more
wiley   +1 more source

Predictive value and mediating effect analysis of the AHR-ARNT-CYP1A1 axis for missed abortion related to polycyclic aromatic hydrocarbons exposure

Scientific Reports
This study aimed to determine the predictive value of aryl hydrocarbon receptor (AHR) signaling pathway genes, and to detect the mediating effect of AHR that may mediate the influence of polycyclic aromatic hydrocarbons (PAHs) on missed abortion.
Jiuru Cao, Mei Han, Fuxing Li, Jiayu Zhang, Jingru Ji, Junni Wei   +5 more
doaj   +1 more source

Systems analysis of barrier molecule and ARNT-related gene expression regulation in melanoma

OncoImmunology, 2019
Background: We have identified, in melanomas, a set of genes encoding proteins that mediate mechanical barrier function in normal skin (barrier molecule genes, BMGs) and whose overexpression is associated with decreased immune signatures and shorter ...
Katie M. Leick, Joseph M. Obeid, Stefan Bekiranov, Craig L. Slingluff   +3 more
doaj   +1 more source