Results 71 to 80 of about 11,887 (214)

Uterine and ovarian aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in benign and malignant gynaecological conditions [PDF]

Molecular Human Reproduction, 2002
The transcriptional regulators aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) modulate the transcription of genes involved in cellular differentiation and proliferation. In this study, we investigated the expression of these transcriptional regulators in the female reproductive tract.
O, Khorram, M, Garthwaite, T, Golos
openaire   +2 more sources

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

The FEBS Journal, Volume 293, Issue 8, Page 2393-2416, April 2026.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera, Shiyang Song, Sofia Ylinen, Talha Qureshi, Bin Li, Zhi Chen   +5 more
wiley   +1 more source

Aryl hydrocarbon receptor: current perspectives on key signaling partners and immunoregulatory role in inflammatory diseases

Frontiers in Immunology
The aryl hydrocarbon receptor (AhR) is a versatile environmental sensor and transcription factor found throughout the body, responding to a wide range of small molecules originating from the environment, our diets, host microbiomes, and internal ...
Fatemah Bahman, Khubaib Choudhry, Fatema Al-Rashed, Fahd Al-Mulla, Sardar Sindhu, Sardar Sindhu, Rasheed Ahmad   +6 more
doaj   +1 more source

PP2A phosphatase inhibition is anti-fibrotic through Ser77 phosphorylation-mediated ARNT/ARNT homodimer formation

Scientific Reports, 2021
Aryl hydrocarbon receptor nuclear translocator (ARNT) mediates anti-fibrotic activity in kidney and liver through induction of ALK3-receptor expression and subsequently increased Smad1/5/8 signaling.
Gunsmaa Nyamsuren, Gregor Rapp, Hassan Dihazi, Elisabeth M. Zeisberg, Desiree Tampe, Björn Tampe, Michael Zeisberg   +6 more
doaj   +1 more source

A Window of Vulnerability: Chronic Environmental Stress Does Not Impair Reproduction in the Swordfish Xiphias gladius

Animals, 2023
Xiphias gladius is an important fishing resource. The Mediterranean stock is affected by overfishing and is declining. In this light, the aim of this study was to evaluate the cross-talk among metabolism, stress response, immune system and reproduction ...
Giorgia Gioacchini, Sara Filippi, Rossella Debernardis, Luca Marisaldi, Riccardo Aiese Cigliano, Oliana Carnevali   +5 more
doaj   +1 more source

Muscle Bmal1 is Dispensable for the Progress of Neurogenic Muscle Atrophy in Mice

Journal of Circadian Rhythms, 2016
Global deletion of aryl hydrocarbon receptor nuclear translocator-like ('Arntl'; also known as 'Bmal1'), a molecular component of the circadian clock, resulted in an extreme loss of muscle mass.
Reiko Nakao, Shigeki Shimba, Katsutaka Oishi   +2 more
doaj   +1 more source

Identification of genes differentially expressed between benign and osteopontin transformed rat mammary epithelial cells [PDF]

, 2009
Background Osteopontin is a secreted, integrin-binding and phosphorylated acidic glycoprotein which has an important role in tumor progression. Findings In this study, we have utilized suppressive subtractive hybridization (SSH) to evaluate OPN regulated
Vittal V Kurisetty, Patrick G Johnston, Philip S Rudland, Mohamed K El-Tanani   +3 more
core   +2 more sources

Time‐of‐Day Impacts Uterine Circadian Rhythms and Response to Oxytocin: Comparison of Uterine Function in Melatonin‐Deficient C57BL/6 Versus Melatonin Proficient CBA/B6 Hybrid Mice

Journal of Pineal Research, Volume 78, Issue 2, March 2026.
ABSTRACT Reaching term gestation requires a complex interplay between the uterus and hormonal signals regulating its contractile profile. Most pregnancy‐associated hormones vary in their overall level of release throughout pregnancy, but also have a circadian release pattern, including progesterone, oxytocin, and melatonin. It remains poorly understood
Thu Van‐Quynh Duong, Alexandra M. Yaw, Hanne M. Hoffmann   +2 more
wiley   +1 more source

ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis

Oncogenesis, 2021
The metabolic changes in melanoma cells that are required for tumor metastasis have not been fully elucidated. In this study, we show that the increase in glucose uptake and mitochondrial oxidative phosphorylation confers metastatic ability as a result ...
Chi-Ruei Huang, Ting-Wei Chang, Chung-Ta Lee, Chih-Jie Shen, Wen-Chang Chang, Ben-Kuen Chen   +5 more
doaj   +1 more source

Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

BioFactors, Volume 52, Issue 1, January/February 2026.
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra, Chia‐Che Ku, Ying‐Chu Lin, Yi‐Chun Tsai, Deng‐Chyang Wu, Yukio Mitsui, Maki Satou, Yuuki Tanaka, Shigeo Saito, Kazunari K. Yokoyama   +9 more
wiley   +1 more source