Results 51 to 60 of about 11,887 (214)

When evolution is the solution to pollution : key principles, and lessons from rapid repeated adaptation of killifish (Fundulus heteroclitus) populations [PDF]

, 2017
© The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Evolutionary Applications 10 (2017): 762–783, doi:10.1111/eva.12470.For most species, evolutionary ...
Clark, Bryan W., Hahn, Mark E., Nacci, Diane E., Reid, Noah M., Whitehead, Andrew   +4 more
core   +1 more source

Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders [PDF]

, 2016
Cytochrome P450 (CYP) enzymes for which there is no functional information are considered "orphan" CYPs. Previous studies showed that CYP20A1, an orphan, is expressed in human hippocampus and substantia nigra, and in zebrafish (Danio rerio) CYP20A1 ...
Akira Kubota, Avadhani, Bairoch, Balasubramanian, Barnes, Benjamin Lemaire, Birnie, Boucher, Bryson, Cartharius, Chan, Cheng, Choudhary, Conor M. O'Meara, Coward, Dahlman-Wright, David C. Lamb, Flicek, Giguere, Goldstone, Gorelick, Grandjean, Gupta, Hassan, Honkakoski, Houck, Hulce, James-Zorn, Jared V. Goldstone, Jetten, John J. Stegeman, Jonsson, Jonsson, Kalaany, Kalueff, Krasowski, Krogh, Kubota, Kumar, Lamb, Livak, Maaswinkel, Maximino, Meling, Mitro, Morrison, Nakai, Nelson, Nelson, Otyepka, Petersen, Petersen, Ramos-Santana, Reschly, Robert L. Tanguay, Rost, Sezutsu, Stark, Stark, Strunnikova, Takiguchi, Thisse, Tomaszewska, Truong, Werck-Reichhart, Wirdefeldt, Xu, Yeh, Zhou   +68 more
core   +1 more source

Regulation of mouse small heat shock protein αb-crystallin gene by aryl hydrocarbon receptor. [PDF]

PLoS ONE, 2011
The stress-inducible small heat shock protein (shsp)/αB-crystallin gene is expressed highly in the lens and moderately in other tissues. Here we provide evidence that it is a target gene of the aryl hydrocarbon receptor (AhR) transcription factor.
Shuang Liu, Joram Piatigorsky
doaj   +1 more source

The circadian clock component BMAL1 regulates osteogenesis in osseointegration

Frontiers in Pediatrics, 2022
Congenital and developmental craniofacial deformities often cause bone defects, misalignment, and soft tissue asymmetry, which can lead to facial function and morphologic abnormalities, especially among children born with cleft lip and palate.
Shiyong Deng, Shiyong Deng, Meiyao Qi, Meiyao Qi, Ping Gong, Ping Gong, Zhen Tan, Zhen Tan   +7 more
doaj   +1 more source

Influence of oxidative stress on aryl hydrocarbon receptor signaling [PDF]

, 2013
The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per- Arnt-Sim) super-family of transcription factors.
Mohammadi Bardbori, Afshin
core   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

2,3,7,8‑Tetrachlorodibenzo‑p‑dioxin suppresses the growth of human liver cancer HepG2 cells in vitro: Involvement of cell signaling factors. [PDF]

, 2018
The aryl hydrocarbon receptor (AHR) is transcriptionally active in the form of a heterodimer with the AHR nuclear translocator, which then binds to the xenobiotic responsive element.
Hankinson, Oliver, Yamaguchi, Masayoshi
core  

Iron Physiology and Its Impact on Atopic Diseases: An EAACI Taskforce Report

Allergy, EarlyView.
ABSTRACT Iron is essential for oxygen transport, energy metabolism, and immune regulation. Yet iron deficiency is the most common micronutrient disorder across all age groups, affecting nearly one quarter of the global population. Iron deficiency triggers nutritional immunity, a host defense mechanism that withholds and redistributes iron, contributing
Franziska Roth‐Walter, Ioana Agache, Beatriz Cabanillas, Roberto Berni Canani, Pasquale Comberiati, Holger Garn, Cristina Gomez‐Casado, Karin Hufnagl, Ekaterina Khaleva, Gregorio P. Milani, Daniel Munblit, Nikolaos Douladiris, Liam O'Mahony, Frank Redegeld, Carmen Riggioni, Peter K. Smith, Betty van Esch, Emilia Vassilopoulou, Carina Venter, Diego G. Peroni   +19 more
wiley   +1 more source

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors

eLife, 2016
The neuronal PAS domain proteins NPAS1 and NPAS3 are members of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family, and their genetic deficiencies are linked to a variety of human psychiatric disorders including schizophrenia, autism spectrum ...
Dalei Wu, Xiaoyu Su, Nalini Potluri, Youngchang Kim, Fraydoon Rastinejad   +4 more
doaj   +1 more source

Nobiletin Attenuates Anesthesia/Surgery-Induced Neurocognitive Decline by Preserving the Expression of Clock Genes in Mice

Frontiers in Neuroscience, 2022
Postoperative cognitive dysfunction (POCD) is commonly observed during the postoperative period and significantly affects the prognosis of patients. Neuroinflammation plays a vital role in the pathogenesis of POCD.
Zhuonan Sun, Ning Yang, Xixi Jia, Yanan Song, Dengyang Han, Xiaoxiao Wang, Jie Sun, Zhengqian Li, Zhiyi Zuo, Xiangyang Guo   +9 more
doaj   +1 more source