Results 61 to 70 of about 11,887 (214)

Expression of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Nuclear Translocator Messenger Ribonucleic Acids and Proteins in Rat and Human Testis [PDF]

Endocrinology, 2003
Dioxins, e.g. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), use the aryl hydrocarbon receptor (AHR)/aryl hydrocarbon receptor nuclear translocator (ARNT) receptor complex to mediate their toxic actions. In addition to interaction with environmental pollutants, several transcription factors, steroid receptors, and growth factors are capable interacting ...
Rüdiger, Schultz, Janne, Suominen, Tanja, Värre, Harri, Hakovirta, Martti, Parvinen, Jorma, Toppari, Markku, Pelto-Huikko   +6 more
openaire   +2 more sources

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

ARNT is a potential direct HIF-1 target gene in human Hep3B hepatocellular carcinoma cells

Cancer Cell International, 2017
Background The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT) participates in the hypoxia-inducible factor (HIF) pathway which senses a decline in cellular oxygen tension.
Markus Mandl, Reinhard Depping
doaj   +1 more source

An increase in reactive oxygen species by deregulation of ARNT enhances chemotherapeutic drug-induced cancer cell death. [PDF]

PLoS ONE, 2014
BACKGROUND: Unique characteristics of tumor microenvironments can be used as targets of cancer therapy. The aryl hydrocarbon receptor nuclear translocator (ARNT) is an important mediator of tumor progression.
Jiunn-Min Shieh, Chih-Jie Shen, Wei-Chiao Chang, Hung-Chi Cheng, Ya-Yi Chan, Wan-Chen Huang, Wen-Chang Chang, Ben-Kuen Chen   +7 more
doaj   +1 more source

Recruitment of the NCoA/SRC-1/p160 Family of Transcriptional Coactivators by the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Complex [PDF]

Molecular and Cellular Biology, 2002
The aryl hydrocarbon receptor complex heterodimeric transcription factor, comprising the basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) proteins, mediates the toxic effects of TCDD (2,3,7,8 tetrachlorodibenzo-p-dioxin).
Timothy V, Beischlag, Song, Wang, David W, Rose, Joseph, Torchia, Suzanne, Reisz-Porszasz, Khurshid, Muhammad, Walter E, Nelson, Markus R, Probst, Michael G, Rosenfeld, Oliver, Hankinson   +9 more
openaire   +2 more sources

Dioxin Exposure Blocks Lactation Through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor Repressor [PDF]

, 2015
In mammals, lactation is a rich source of nutrients and antibodies for newborn animals. However, millions of mothers each year experience an inability to breastfeed.
Basham, Kaitlin J., Bhonde, Vasudev R., Kieffer, Collin, Leonard, Christopher J., Looper, Ryan E., McDowell, Maria E., Shelton, Dawne N., Welm, Bryan E.   +7 more
core  

Npas4 is activated by melatonin, and drives the clock gene Cry1 in the ovine pars tuberalis [PDF]

, 2013
Seasonal mammalsintegrate changes in the duration of nocturnal melatonin secretion to drive annual physiologic cycles. Melatonin receptors within the proximal pituitary region, the pars tuberalis (PT), are essential in regulating seasonal neuroendocrine ...
Burt, Dw, Davis, Jre, Dupre, Sm, Loudon, Asi, McNeilly, As, Miedzinska, K, Paton, Bob, West, A, Yu, L   +8 more
core   +1 more source

Leveraging extracellular vesicle biology for novel tests and therapeutics for kidney fibrosis

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles (EVs) are bilipid membrane‐encased nanoparticles that play critical roles as cell‐to‐cell messengers and waste management mechanisms. EVs cargos can be leveraged as biomarkers to develop minimally invasive tests for kidney fibrosis and guide personalised mechanism‐driven care.
Chin‐Ya Sophie Chiang, Andrew J. Kassianos, Helen Grania Healy, Monica Suet Ying Ng   +3 more
wiley   +1 more source

Signaling via the bHLH-PAS proteins AhR and HIF [PDF]

, 2012
This thesis concerns some mechanistic properties of the basic helix-loop-helix/PAS (bHLH-PAS) factors aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1 alpha (HIF-1α). The bHLH-PAS family of proteins is a family of factors that controls
Bosdotter, Cecilia
core  

BMAL1 Drives Cisplatin Resistance in Non‐Small Cell Lung Cancer Via Lactate‐MRP1 Signaling Pathway

Thoracic Cancer, Volume 17, Issue 8, April 2026.
The drug cisplatin induces BMAL1 expression through AKT signaling in response to cisplatin‐induced oxidative stress. BMAL1 activates HIF‐1α‐mediated metabolic reprogramming and lactate production, which in turn activates the TAZ/c‐Jun/Snail complex to upregulate drug efflux pump MRP1, initiating and sustaining chemoresistance. ABSTRACT Lung cancer, the
Zixin Shi, Ziniu Qin, Chuantao Chen, Xiaolin Yang, Yunhan Hu, Xiaohui Meng, Yuxiang Cao, Xiang Tao, Zhijian Zhang, Tiancheng Xie, Huijun Wei, Zhihao Wu   +11 more
wiley   +1 more source