Results 151 to 160 of about 39,938 (310)

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Metformin inhibits IgE‐ and aryl hydrocarbon receptor‐mediated mast cell activation in vitro and in vivo [PDF]

, 2018
Hsueh‐Chun Wang, Shau‐Ku Huang
openalex   +1 more source

Tapinarof as a Therapeutic Aryl Hydrocarbon Receptor‐Modulating Agent in the Treatment of Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory dermatitis underpinned by Type 2 inflammation driven by cytokines such as IL‐4 and IL‐13. It is characterized by skin barrier dysfunction, Th2 immune deviation, and pruritus. While biologics and oral Janus kinase (JAK) inhibitors demonstrate high therapeutic efficacy by targeting cytokines that ...
Gaku Tsuji, Yoko Fuyuno, Koji Kawamura, Ayako Yumine, Masaki Takemura, Yasutaka Mitamura, Kazuhiko Yamamura, Takeshi Nakahara   +7 more
wiley   +1 more source

Molecular and Functional Properties of the Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a. [PDF]

Environ Sci Technol, 2020
Aranguren-Abadía L, Lille-Langøy R, Madsen AK, Karchner SI, Franks DG, Yadetie F, Hahn ME, Goksøyr A, Karlsen OA.   +8 more
europepmc   +1 more source

Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]

Fundam Clin Pharmacol
ABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc   +2 more sources

Kaempferol Protects Intestinal Health in Chinese Forest Musk Deer Possibly by Regulating Intestinal Microbiota and Inhibiting the NF‐κB/NLRP3 Signaling Pathway

Integrative Zoology, EarlyView.
Kaempferol modulates the tryptophan metabolism pathway by increasing the abundances of Christensenellaceae R7 group, Bacteroides, and Blautia and reducing that of Rikenellaceae RC9 gut group, thereby significantly increasing the levels of ILA and IAA. This process inhibits the activation of NF‐κB/NLRP3 signaling pathway, reduces pro‐inflammatory factor
Xiangyu Liu, Zhanjun Ren, Xiuzhu Sun, Shuhui Wang   +3 more
wiley   +1 more source

Targeted Systemic Therapies for Atopic Dermatitis in Australia: A Narrative Review

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease estimated to affect approximately 30% of children and 10%–15% of adults in Australia. Of those with this condition, one in five is estimated to have moderate‐to‐severe disease.
Diana Rubel, Peter Foley, Kathryn A. Gibson, Anita Townsend, Gabrielle Louise Reppen, William Romero Gallardo   +5 more
wiley   +1 more source

Decision letter: The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

, 2018
Bryan R. Cullen
openalex   +1 more source

Sinomenine induces the generation of intestinal Treg cells and attenuates arthritis via activation of aryl hydrocarbon receptor [PDF]

, 2016
Bei Tong, Xusheng Yuan, Yannong Dou, Xin Wu, Yuhui Wang, Yufeng Xia, Yue Dai   +6 more
openalex   +1 more source

Protective Effects of Maclurin against Benzo[a]pyrene via Aryl Hydrocarbon Receptor and Nuclear Factor Erythroid 2-Related Factor 2 Targeting [PDF]

, 2021
Jangsoon Kim, See‐Hyoung Park, Seyoung Yang, Sae Woong Oh, Kitae Kwon, Se Jin Park, Eunbi Yu, Hyeyoun Kim, Jung Yoen Park, Seoyoung Choi, Seoyeon Yang, Minkyung Song, Jae Youl Cho, Jongsung Lee   +13 more
openalex   +1 more source