Results 91 to 100 of about 17,285 (228)

5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. [PDF]

PLoS ONE, 2013
Folate catabolism involves cleavage of the C(9)-N(10) bond to form p-aminobenzoylgluamate (PABG) and pterin. PABG is then acetylated by human arylamine N-acetyltransferase 1 (NAT1) before excretion in the urine.
Katey L Witham, Neville J Butcher, Kim S Sugamori, Debbie Brenneman, Denis M Grant, Rodney F Minchin   +5 more
doaj   +1 more source

Acetylation genotype and the genetic susceptibility to postate cancer in a Southern European population [PDF]

, 2005
Epidemiologic studies have suggested that environmental factors and diet are important risk factors in the pathogenesis of prostate cancer. The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens ...
Bell, Blum, Brockton, Butcher, Cascorbi, Costa, Ferreira, Fukutome, Garte, Gonzalez, Hamasaki, Hanchette, Hein, Hein, Hein, Hou, Hung, King, Kolonel, Lawson, Medeiros, Medeiros, Medeiros, Medeiros, Mullenbach, Payton, Pienta, Pinheiro, Ribeiro, Rodriguez, Ross, van der Hel, Wadelius, Wang, Xu   +34 more
core   +1 more source

Metabolic Engineering of a Serotonin Overproducing Saccharomyces cerevisiae Strain

Microbial Biotechnology, Volume 18, Issue 4, April 2025.
Yeast strain engineered for serotonin production. The medium and fermentation conditions have been optimised to achieve the highest serotonin production of any S. cerevisiae strain to date. ABSTRACT The EU Green Deal prioritises the transformation of the chemical industry to a more environmentally sustainable model.
Andrés Planells‐Cárcel, Elena Valera‐García, Guillermo Quintas, José Luis Martínez, Sara Muñiz‐Calvo, José Manuel Guillamón   +5 more
wiley   +1 more source

Immunohistochemical determination of the miR-1290 target arylamine N-acetyltransferase 1 (NAT1) as a prognostic biomarker in breast cancer. [PDF]

BMC Cancer, 2014
There are many molecular differences between estrogen receptor α (ERα)-positive and ER-negative breast cancers. Recent analyses have shown that the former can be divided into two subtypes, luminal A and luminal B.
Endo Y, Yamashita H, Takahashi S, Sato S, Yoshimoto N, Asano T, Hato Y, Dong Y, Fujii Y, Toyama T.   +9 more
europepmc   +2 more sources

Evolutionary formation of melatonin and vitamin D in early life forms: insects take centre stage

Biological Reviews, Volume 99, Issue 5, Page 1772-1790, October 2024.
ABSTRACT Melatonin, a product of tryptophan metabolism via serotonin, is a molecule with an indole backbone that is widely produced by bacteria, unicellular eukaryotic organisms, plants, fungi and all animal taxa. Aside from its role in the regulation of circadian rhythms, it has diverse biological actions including regulation of cytoprotective ...
Tae‐Kang Kim, Radomir M. Slominski, Elzbieta Pyza, Konrad Kleszczynski, Robert C. Tuckey, Russel J. Reiter, Michael F. Holick, Andrzej T. Slominski   +7 more
wiley   +1 more source

Interaction between dietary and lifestyle risk factors and N-Acetyltransferase polymorphisms in B-Cell lymphoma etiology [PDF]

, 2015
Background: Gene-environment interactions are suggested to play a role in lymphomagenesis. Methods: We tested the interaction between the NAT1/NAT2 phenotype, as inferred by the respective genotypes, and exposure to dietary and lifestyle risk factors ...
Angelucci, E, CAMPAGNA, MARCELLO, COCCO, PIER LUIGI, ENNAS, MARIA GRAZIA, GABBAS, ATTILIO, Monne, M, SANNA, SONIA, SATTA, GIANNINA, Scarpa, A, ZUCCA, MARIAGRAZIA   +9 more
core   +1 more source

Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland.

Journal of Biological Chemistry, 1984
Amine N-acetylation in the pineal gland is of special importance because it is the first step in the synthesis of melatonin from serotonin. In the present study the N-acetylation of arylamines and arylalkylamines by homogenates of rat and sheep pineal glands was investigated.
David C. Klein, Pierre Voisin, M. A. A. Namboodiri   +2 more
openaire   +2 more sources

Sexually dimorphic traits are associated with subsistence strategy in African faces from the Sahel/Savannah belt

American Journal of Human Biology, Volume 36, Issue 4, April 2024.
Abstract Objectives Previous research revealed that in some African populations, food‐production strategies are associated with facial shape. Nomadic pastoralists living in the African Sahel/Savannah belt have a different facial morphology than their sedentary neighbors. We investigated whether the lifestyle associated with a subsistence pattern has an
Karel Kleisner, Šimon Pokorný, Viktor Černý   +2 more
wiley   +1 more source

The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) [PDF]

, 2017
The metabolic activation of the heterocyclic food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by two human cytochrome P450 monooxygenases (P4501A1 and P4501A2) and two human N-acetyltransferases (NAT1 and NAT2) was investigated.
Blum, Martin, D'Orazio, Daniel, Fasshauer, Ingrid, Meyer, Urs A., Probst, Markus R., Wild, Dieter   +5 more
core  

Leukocytoclastic vasculitis caused by sulfamethoxazole‐trimethoprim

Clinical Case Reports, Volume 12, Issue 2, February 2024.
Violaceous round papules and a surrounding rim of macular purpura coalescing into plaques on both feet 8 days after starting sulfamethoxazole‐trimethoprim. Key Clinical Message Leukocytoclastic vasculitis is a rare, small‐vessel vasculitis that can be caused by sulfamethoxazole‐trimethoprim.
Parjanya Bhatt, Nadine Montreuil, Ayoola Olayiwola, Tanya Quiroz, Felipe Ruiz, Folusakin Ayoade   +5 more
wiley   +1 more source