Results 91 to 100 of about 17,361 (234)
Journal of Infection in Developing Countries, 2012 Introduction: Arylamine N-acetyltransferase-2 (NAT-2) is a key human enzyme in drug detoxification and elimination. Mutations in NAT-2 affect the activity of anti-tuberculosis drugs and result in three different phenotypes: rapid (RA), intermediate (IA)
Julián Gabriel Chamorro +5 more
doaj +1 more source
International Journal of Infectious Diseases, 2022 Objectives: This study investigated the steady-state pharmacokinetic profiles of 3-month weekly rifapentine plus isoniazid (3HP) in children with latent tuberculosisinfection (LTBI).
Weeraya Phaisal +6 more
doaj +1 more source
Changes in consensus arylamine N-acetyltransferase gene nomenclature [PDF]
Pharmacogenetics and Genomics, 2008 Changes in consensus arylamine N-acetyltransferase (NAT) gene nomenclature determined at the 2007 International NAT Workshop include: (1) Alleles in all species except mouse and rat are all uppercase. For mouse and rat, the first letter is upper case followed by lower case. (2) The nomenclature system is now species-specific.
Hein, David W. +4 more
openaire +3 more sources
5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. [PDF]
PLoS ONE, 2013 Folate catabolism involves cleavage of the C(9)-N(10) bond to form p-aminobenzoylgluamate (PABG) and pterin. PABG is then acetylated by human arylamine N-acetyltransferase 1 (NAT1) before excretion in the urine.
Katey L Witham +5 more
doaj +1 more source
Molecular Pharmacology, 2020 Arylamine N-acetyltransferase 1 (NAT1) is a phase II xenobiotic-metabolizing enzyme that also has a role in cancer cell growth and metabolism. Recently, it was reported that NAT1 undergoes lysine acetylation, an important post-translational modification ...
N. Butcher, Rachel Burow, R. Minchin
semanticscholar +1 more source
Identification of Anoikis‐Related Subgroups and Prognosis Model in Colon Cancer
Cancer Nexus, Volume 1, Issue 2, July 2025.ABSTRACT Background Anoikis represents a distinct type of programmed cell death that serves a critical function in tumor development and metastatic. Despite its significance, there remains a notable gap in comprehensive studies that explore the role of Anoikis specifically within the context of colon cancer (CC). Thus, it becomes imperative to pinpoint
Shaokang Yang +5 more
wiley +1 more source
Antitubercular specific activity of ibuprofen and the other 2-arylpropanoic acids using the HT-SPOTi whole-cell phenotypic assay [PDF]
, 2013 Objectives: Lead antituberculosis (anti-TB) molecules with novel mechanisms of action are urgently required to fuel the anti-TB drug discovery pipeline.
Bhakta, Sanjib +9 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1338-1357, May 2025.Tuberculosis (TB) is a major health burden in Africa. Although TB is treatable, anti‐TB drugs are associated with adverse drug reactions (ADRs), which are partly attributed to pharmacogenetic variation. The distribution of star alleles (haplotypes) influencing anti‐TB drug metabolism is unknown in many African populations.
Thandeka V.B. Malinga +6 more
wiley +1 more source
Metabolic Engineering of a Serotonin Overproducing Saccharomyces cerevisiae Strain
Microbial Biotechnology, Volume 18, Issue 4, April 2025.Yeast strain engineered for serotonin production. The medium and fermentation conditions have been optimised to achieve the highest serotonin production of any S. cerevisiae strain to date. ABSTRACT The EU Green Deal prioritises the transformation of the chemical industry to a more environmentally sustainable model.
Andrés Planells‐Cárcel +5 more
wiley +1 more source
N-Acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers [PDF]
, 2017 Several studies in subjects occupationally exposed to arylamine carcinogens have shown increased risks for bladder cancer associated with the slow acetylator phenotype.
Bi, Wenfang +9 more
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