Results 51 to 60 of about 17,285 (228)

Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity. [PDF]

Mol Carcinog, 2018
Human arylamine N‐acetyltransferase 1 (NAT1) is a phase II xenobiotic metabolizing enzyme found in almost all tissues. NAT1 can also hydrolyze acetyl‐coenzyme A (acetyl‐CoA) in the absence of an arylamine substrate.
Carlisle SM, Trainor PJ, Doll MA, Stepp MW, Klinge CM, Hein DW.   +5 more
europepmc   +2 more sources

NAT2 and CYP2E1 polymorphisms and antituberculosis drug‐induced hepatotoxicity in Peruvian patients

Molecular Genetics &Genomic Medicine, Volume 10, Issue 8, August 2022., 2022
According to our results, the combination of the NAT2 polymorphism associated with the intermediate phenotype and the CYP2E1 C1/C1 genotype associated with the slow phenotype does not affect the therapeutic response and is suspected to be a protective factor against INH‐induced hepatotoxicity in Peruvian tuberculosis patients.
Luis Jaramillo‐Valverde, Kelly S. Levano, David D. Tarazona, Silvia Capristano, Roberto Zegarra‐Chapoñan, Cesar Sanchez, Velia M. Yufra‐Picardo, Eduardo Tarazona‐Santos, Cesar Ugarte‐Gil, Heinner Guio   +9 more
wiley   +1 more source

Drug Disposition Protein Quantification in Matched Human Jejunum and Liver From Donors With Obesity

Clinical Pharmacology &Therapeutics, Volume 111, Issue 5, Page 1142-1154, May 2022., 2022
Mathematical models, such as physiologically‐based pharmacokinetic models, are used to predict, for example, drug disposition and toxicity. However, populations differ in the abundance of proteins involved in these processes. To improve the building and refinement of such models, they must take into account these interindividual variabilities.
Christine Wegler, Jacek R. Wiśniewski, Ida Robertsen, Hege Christensen, Jens Kristoffer Hertel, Jøran Hjelmesæth, Rasmus Jansson‐Löfmark, Anders Åsberg, Tommy B. Andersson, Per Artursson   +9 more
wiley   +1 more source

Arylamine N-acetyltransferase 2 Polymorphisms and the Risk of Endometriosis. [PDF]

Avicenna J Med Biotechnol, 2018
Barra F, Desideri LF, Scala C, Ferrero S.   +3 more
europepmc   +4 more sources

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice. [PDF]

Proc Natl Acad Sci U S A, 2017
Significance Insulin resistance in liver and skeletal muscle are major factors in the pathogenesis of type 2 diabetes; however, the molecular mechanism or mechanisms responsible for this phenomenon have not been established. Recently, an association of a
Camporez JP, Wang Y, Faarkrog K, Chukijrungroat N, Petersen KF, Shulman GI.   +5 more
europepmc   +2 more sources

Colorectal cancer risk susceptibility loci in a Swedish population

Molecular Carcinogenesis, Volume 61, Issue 3, Page 288-300, March 2022., 2022
Abstract To search for colorectal cancer (CRC) risk loci, Swedish samples were used for a genome‐wide haplotype analysis. A logistic regression model was employed in 2663 CRC cases and 1642 controls in the discovery analysis. Three analyses were done, on all, familial‐, and nonfamilial CRC samples and only results with odds ratio (OR) > 1 were analyzed.
Wen Liu, Hovsep Mahdessian, Hafdis Helgadottir, Xingwu Zhou, Jessada Thutkawkorapin, Xiang Jiao, The Swedish Low‐risk Colorectal Cancer Study Group, Alicja Wolk, Annika Lindblom   +8 more
wiley   +1 more source

Anisi Stellati Fructus, a Significant Traditional Chinese Medicine (TCM) Herb and Its Bioactivity against Gastric Cancer

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Anisi stellati fructus (ASF) is the fruit of Illicium verum Hook F. (Chinese star anise), which is native to many countries, and is a significant Chinese medicinal herb. Gastric cancer (GC) is one of the major fatal types of cancers with multiple stages and a poor prognosis.
Maryam Khan, Saba Shamim, Qing Li
wiley   +1 more source

NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ruiz, JD, Agúndez, JAG, Martínez, C, García-Martín, E   +3 more
openaire   +3 more sources

Advances in Key Drug Target Identification and New Drug Development for Tuberculosis

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control. Therefore, there is an urgent need to develop new anti‐TB drugs to treat drug‐resistant TB and shorten the standard therapy.
Jie Mi, Wenping Gong, Xueqiong Wu, Atef M. Al Attar   +3 more
wiley   +1 more source

[Retracted] Distinctive Metabolism‐Associated Gene Clusters That Are Also Prognostic in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Objective. To offer new prognostic evaluations by exploring potentially distinctive genetic features of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Methods. There were 12 samples for gene expression profiling processes in this study.
Linchao Ding, Shilong Ning, Weijian Hu, Yadong Xue, Shi’an Yu, Md Sayed Ali Sheikh   +5 more
wiley   +1 more source