Results 61 to 70 of about 17,361 (234)

Comparative analysis of xenobiotic metabolising N-acetyltransferases from ten non-human primates as in vitro models of human homologues [PDF]

, 2018
Xenobiotic metabolising N-acetyltransferases (NATs) perform biotransformation of drugs and carcinogens. Human NAT1 is associated with endogenous metabolic pathways of cells and is a candidate drug target for cancer.
Boukouvala, Sotiria, Crouau-Roy, Brigitte, Fakis, Giannoulis, Konstantopoulou, Maria, Ryan, Ali, Sabbagh, Audrey, Sim, Edith, Tsirka, Theodora   +7 more
core   +2 more sources

[Retracted] Distinctive Metabolism‐Associated Gene Clusters That Are Also Prognostic in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Objective. To offer new prognostic evaluations by exploring potentially distinctive genetic features of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Methods. There were 12 samples for gene expression profiling processes in this study.
Linchao Ding, Shilong Ning, Weijian Hu, Yadong Xue, Shi’an Yu, Md Sayed Ali Sheikh   +5 more
wiley   +1 more source

Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina [PDF]

, 2015
Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines ...
Bailliet, Graciela, López Camelo, Jorge Santiago, Muzzio, Marina, Ramallo, Virginia, Santos, María Rita   +4 more
core   +5 more sources

RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition. [PDF]

PLoS ONE, 2011
Arylamine N-acetyltransferase-1 (NAT1) is an enzyme that catalyzes the biotransformation of arylamine and hydrazine substrates. It also has a role in the catabolism of the folate metabolite p-aminobenzoyl glutamate.
Jacky M Tiang, Neville J Butcher, Carleen Cullinane, Patrick O Humbert, Rodney F Minchin   +4 more
doaj   +1 more source

The Use of Plasmapheresis in Treatment of Patients with Infertility, Peritoneal Endometriosis and Nat2 Gene Polymorphism [PDF]

, 2016
It is known that 30–40 % of patients with peritoneal endometriosis suffer from infertility. Half of the patients with endometriosis are identified point mutation in NAT2 – gene, which plays an important role in the acetylation of aromatic and ...
Dubinskaya, E. (Ekaterina), Lapteva, N. (Natalia), Lukyanova, Y. (Yana)   +2 more
core   +2 more sources

Alcohol consumption, tobacco smoking, and subsequent risk of renal cell carcinoma: The JPHC study

Cancer Science, Volume 112, Issue 12, Page 5068-5077, December 2021., 2021
Abstract The effects of alcohol consumption and tobacco smoking on renal cell carcinoma (RCC) incidence have not been well‐investigated in Asian populations. Here, we evaluated these effects in a large Japanese prospective cohort. We collected data on eligible participants in the Japan Public Health Center‐based Prospective Study, and undertook ...
Tetsuji Minami, Manami Inoue, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Shoichiro Tsugane   +5 more
wiley   +1 more source

Oral enzymatic detoxification system: Insights obtained from proteome analysis to understand its potential impact on aroma metabolization

Comprehensive Reviews in Food Science and Food Safety, Volume 20, Issue 6, Page 5516-5547, November 2021., 2021
Abstract The oral cavity is an entry path into the body, enabling the intake of nutrients but also leading to the ingestion of harmful substances. Thus, saliva and oral tissues contain enzyme systems that enable the early neutralization of xenobiotics as soon as they enter the body.
Mathieu Schwartz, Fabrice Neiers, Jean‐Philippe Charles, Jean‐Marie Heydel, Carolina Muñoz‐González, Gilles Feron, Francis Canon   +6 more
wiley   +1 more source

Carcinogenic potential of arylamine N-acetyltransferase in Asian populations

Journal of Cancer Research and Practice, 2018
Arylamine N-acetyltransferase (NAT) is a phase II metabolizing enzyme, which belongs to the transferase family; specifically those acyltransferases which transfer various groups except aminoacyl. NATs are found in both prokaryotes and eukaryotes.
Saba Kabir, Abdul Rehman
doaj   +1 more source

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene [PDF]

, 2015
Journal ArticleDecreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, the genetic basis
Alan Sinaiko, Andrea Ganna, Andrew P. Morris, Anubha Mahajan, Bosy-Westphal, Cartwright, Cecilia Lindgren, Chao A. Hsiung, Cliona Molony, Danielle M. Greenawalt, DeFronzo, Deloukas, Einhorn, Eric E. Schadt, Erik Ingelsson, Fahim Abbasi, Gerald Reaven, Grant, Grant, Greenfield, Heather J. Cordell, Hein, Indumathi Chennemsetty, Ivan Carcamo-Orive, James Pankow, Jerome I. Rotter, Joshua W. Knowles, Jussi Paananen, Ke Hao, Lars Lind, Leif Groop, Leslie J. Raffel, Mark O. Goodarzi, Mark Walker, Markku Laakso, Michael N. Weedon, Ola Hansson, Pek Lum, Philip S. Tsao, Reaven, Themistocles L. Assimes, Thomas Quertermous, Timothy M. Frayling, Ville-Petteri Mäkinen, Weijia Xie, Xia Yang, Xiuqing Guo, Yii-Der I. Chen, Zhongyang Zhang   +48 more
core   +1 more source

The role of lysine100 in the binding of acetylcoenzyme A to human arylamine N-acetyltransferase 1: Implications for other acetyltransferases [PDF]

, 2015
The arylamine N-acetyltransferases (NATs) catalyze the acetylation of aromatic and heterocyclic amines as well as hydrazines. All proteins in this family of enzymes utilize acetyl coenzyme A (AcCoA) as an acetyl donor, which initially binds to the enzyme
Butcher, Neville J, Minchin, Rodney F
core   +1 more source