Pharmacogenetics of the arylamine N-acetyltransferases [PDF]
The Pharmacogenomics Journal, 2002 The arylamine N-acetyltransferases (NATs) are involved in the metabolism of a variety of different compounds that we are exposed to on a daily basis. Many drugs and chemicals found in the environment, such as those in cigarette smoke, car exhaust fumes and in foodstuffs, can be either detoxified by NATs and eliminated from the body or bioactivated to ...
Butcher, N. J. +3 more
openaire +3 more sources
Exploration of Piperidinols as Potential Antitubercular Agents
Molecules, 2014 Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N ...
Areej Abuhammad +6 more
doaj +1 more source
Acetylation genotype and the genetic susceptibility to postate cancer in a Southern European population [PDF]
, 2005 Epidemiologic studies have suggested that environmental factors and diet are important risk factors in the pathogenesis of prostate cancer. The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens ...
Bell +34 more
core +1 more source
Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
Annals of Human Biology, 2017 Background: The arylamine N-acetyltransferase 2 (NAT2) is a key enzyme in the biotransformation of xenobiotics. NAT2 gene polymorphisms have been associated with the risk of isoniazid hepatotoxicity and these polymorphisms change among different ...
Hiba Chelouti, Malika Khelil
doaj +1 more source
Determination of Human NAT2 Acetylator Genotype by Oligonucleotide Ligation Assay
BioTechniques, 1997 The oligonucleotide ligation assay (OLA) was adapted to the genotyping of the N-arylamine-acetyltransferase (NAT2) gene. This assay allows the use of 96-well microplates and robotic workstations for high sample throughput.
Jeannette Bigler +2 more
doaj +1 more source
Annals of Hepatology, 2020 Introduction and objective: Hepatotoxicity during tuberculosis (TB) treatment is frequent and may be related to the Arylamine N-Acetyltransferase (NAT2) acetylator profile, in which allele frequencies differ according to the population.
Carolline Araujo-Mariz +8 more
doaj +1 more source
A novel color change mechanism for breast cancer biomarker detection: naphthoquinones as specific ligands of human arylamine N-acetyltransferase 1. [PDF]
PLoS ONE, 2013 Human arylamine N-acetyltransferase 1 (hNAT1) has become an attractive potential biomarker for estrogen-receptor-positive breast cancers. We describe here the mechanism of action of a selective non-covalent colorimetric biosensor for the recognition of ...
Nicola Laurieri +11 more
doaj +1 more source
Identification of critical residues of the serotype modifying O-acetyltransferase of Shigella flexneri [PDF]
, 2016 BACKGROUND Thirteen serotypes of Shigella flexneri (S. flexneri) have been recognised, all of which are capable of causing bacillary dysentery or shigellosis. With the emergence of the newer S.
Thanweer, Farzaana, Verma, Naresh K
core +1 more source
Microbial Cell Factories, 2020 Background 2-Acetamidophenol (AAP) is an aromatic compound with the potential for antifungal, anti-inflammatory, antitumor, anti-platelet, and anti-arthritic activities.
Shuqi Guo +4 more
doaj +1 more source
New oxadiazole derivatives of isonicotinohydrazide in the search for antimicrobial agents: Synthesis and in vitro evaluation [PDF]
Journal of the Serbian Chemical Society, 2012 Structural modification of the front line antitubercular drug isoniazid provide a lipophilic adaptations of the drug in which hydrazide moiety of isoniazid is replaced by 1,3,4-oxadiazole heterocycles to eliminate in-vivo acetylation by arylamine N ...
Malhotra Manav +3 more
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