Results 71 to 80 of about 17,285 (228)

Neonatal Ontogeny of Murine Arylamine N-Acetyltransferases: Implications for Arylamine Genotoxicity [PDF]

Toxicological Sciences, 2003
Age-related changes in the expression of xenobiotic biotransformation enzymes can result in differences in the rates of chemical activation and detoxification, affecting responses to the therapeutic and/or toxic effects of chemicals. Despite recognition that children and adults may exhibit differences in susceptibility to chemicals, information about ...
Binh Chau, Charlene A. McQueen
openaire   +3 more sources

Structure and Mechanism of Arylamine N-Acetyltransferases

Current Topics in Medicinal Chemistry, 2006
Arylamine N-acetyltransferases (NATs) are a family of phase II drug-metabolising enzymes which are important in the biotransformation of various aromatic and heterocyclic amines and hydroxylamines, arylhydrazines and arylhydrazides. NATs are present in a wide range of eukaryotes and prokaryotes.
Westwood, I M, Kawamura, A, Fullam, E, Russell, A J, Davies, S G, Sim, E   +5 more
openaire   +3 more sources

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene [PDF]

, 2015
Journal ArticleDecreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, the genetic basis
Alan Sinaiko, Andrea Ganna, Andrew P. Morris, Anubha Mahajan, Bosy-Westphal, Cartwright, Cecilia Lindgren, Chao A. Hsiung, Cliona Molony, Danielle M. Greenawalt, DeFronzo, Deloukas, Einhorn, Eric E. Schadt, Erik Ingelsson, Fahim Abbasi, Gerald Reaven, Grant, Grant, Greenfield, Heather J. Cordell, Hein, Indumathi Chennemsetty, Ivan Carcamo-Orive, James Pankow, Jerome I. Rotter, Joshua W. Knowles, Jussi Paananen, Ke Hao, Lars Lind, Leif Groop, Leslie J. Raffel, Mark O. Goodarzi, Mark Walker, Markku Laakso, Michael N. Weedon, Ola Hansson, Pek Lum, Philip S. Tsao, Reaven, Themistocles L. Assimes, Thomas Quertermous, Timothy M. Frayling, Ville-Petteri Mäkinen, Weijia Xie, Xia Yang, Xiuqing Guo, Yii-Der I. Chen, Zhongyang Zhang   +48 more
core   +1 more source

Asociación entre polimorfismos del gen NAT2 y fisura labiopalatina no sindrómica en Argentina [PDF]

, 2015
Background: NAT genes are considered candidate genes for the genetic predisposition to non-syndromic Cleft lip with or without cleft palate (NSCLP), since they codify for N-acetyltransferases, enzymes responsible for the biotransformation of arylamines ...
Bailliet, Graciela, López Camelo, Jorge Santiago, Muzzio, Marina, Ramallo, Virginia, Santos, María Rita   +4 more
core   +5 more sources

Exploration of Piperidinols as Potential Antitubercular Agents

Molecules, 2014
Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N ...
Areej Abuhammad, Elizabeth Fullam, Sanjib Bhakta, Angela J. Russell, Garrett M. Morris, Paul W. Finn, Edith Sim   +6 more
doaj   +1 more source

Human Arylamine N-Acetyltransferase 1 Is Inhibited by the Dithiocarbamate Pesticide Thiram

Molecular Pharmacology, 2017
Ximing Xu, Cécile Mathieu, Jérémy Berthelet, Romain Duval, Linh Chi Bui, Florent Busi, Jean‐Marie Dupret, Fernando Rodrigues‐Lima   +7 more
openalex   +2 more sources

Determination of Human NAT2 Acetylator Genotype by Oligonucleotide Ligation Assay

BioTechniques, 1997
The oligonucleotide ligation assay (OLA) was adapted to the genotyping of the N-arylamine-acetyltransferase (NAT2) gene. This assay allows the use of 96-well microplates and robotic workstations for high sample throughput.
Jeannette Bigler, Chu Chen, John D. Potter   +2 more
doaj   +1 more source

Identification of new arylamine N-acetyltransferases and enhancing 2-acetamidophenol production in Pseudomonas chlororaphis HT66

Microbial Cell Factories, 2020
Background 2-Acetamidophenol (AAP) is an aromatic compound with the potential for antifungal, anti-inflammatory, antitumor, anti-platelet, and anti-arthritic activities.
Shuqi Guo, Yunxiao Wang, Wei Wang, Hongbo Hu, Xuehong Zhang   +4 more
doaj   +1 more source

Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women [PDF]

, 2011
Background: Cigarette smoking is an established risk factor for bladder cancer. Epidemiological and biological data suggest that genetic polymorphisms in activating and detoxifying enzymes may play a role in determining an individual's susceptibility to ...
De Vivo, Immaculata, McGrath, Monica, Michaud, Dominique   +2 more
core   +1 more source

Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis [PDF]

, 2014
MSMEG_0307 is annotated as a transcriptional regulator belonging to the AraC protein family and is located adjacent to the arylamine N-acetyltransferase (nat) gene in Mycobacterium smegmatis, in a gene cluster, conserved in most environmental ...
Abuhammad, Altschul, Anderton, Annemieke M.C. ten Bokum, Antima Gupta, Arundhati Maitra, Bailey, Bailey, Bardarov, Bhakta, Braibant, Camacho, Camus, Carver, Carver, Dimitrios Evangelopoulos, Edith Sim, Evangelopoulos, Frota, Gallegos, Griffin, Kendall, Kendall, Lack, Lack, Livak, Madar, McWilliam, Mulder, Munson, Nathan A. Lack, Pasca, Payton, Rosenfeld, Sanjib Bhakta, Schleif, Sharon Kendall, Singh, Singh, Singh, Singh, Snapper, Staron, Stover, Taneja, Van der Geize, Veleba, Wade, Yam   +48 more
core   +1 more source