Results 81 to 90 of about 17,361 (234)

Folate catabolites in spot urine as non-invasive biomarkers of folate status during habitual intake and folic acid supplementation. [PDF]

, 2013
Folate status, as reflected by red blood cell (RCF) and plasma folates (PF), is related to health and disease risk. Folate degradation products para-aminobenzoylglutamate (pABG) and para-acetamidobenzoylglutamate (apABG) in 24 hour urine have recently ...
A Lobo, A Schulze, AA Sokoro, AA West, AC Verkleij-Hagoort, AD Smith, Astrid Rauh-Pfeiffer, B Hooshmand, B Shane, Berthold Koletzko, DB Matchar, Diego Moretti, DL McKay, DS Wald, EC Witte, FL Geoghegan, H Bartels, H Bozbas, H Refsum, HA Kim, Hans Demmelmair, J McPartlin, J Seppala, JF Gregory, JF Gregory III, JF Gregory III, JF Gregory III, JF Gregory III, JJ Tomaszewski, JM Wolfe, K Pietrzik, KC Scott, KS Crider, L Hao, LA Houghton, LE Daly, M Ebbing, M Herrmann, MA Caudill, MA Caudill, Mareile Niesser, Marola van Lipzig, PA Kownacki-Brown, R Hannisdal, R Prinz-Langenohl, R Prinz-Langenohl, RA Jacob, RF Minchin, S Bart Sr, S Mönch, S O’Broin, S-C Chuang, SA Harris, SJ Mann, TE Stites, Thea Weith, U Ericson, V Veeranna, Wolfgang Peissner, Wouter Vaes, YI Kim, Zulfiqar A. Bhutta   +61 more
core   +9 more sources

Acetylator Genotype-Dependent Dyslipidemia in Rats Congenic for N-Acetyltransferase 2

Toxicology Reports, 2020
Recent reports suggest that arylamine N-acetyltransferases (NAT1 and/or NAT2) serve important roles in regulation of energy utility and insulin sensitivity. We investigated the interaction between diet (control vs. high-fat diet) and acetylator phenotype
Kyung U. Hong, Mark A. Doll, Angeliki Lykoudi, Raúl A. Salazar-González, Mariam R. Habil, Kennedy M. Walls, Alaa F. Bakr, Smita S. Ghare, Shirish S. Barve, Gavin E. Arteel, David W. Hein   +10 more
doaj   +1 more source

Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women [PDF]

, 2011
Background: Cigarette smoking is an established risk factor for bladder cancer. Epidemiological and biological data suggest that genetic polymorphisms in activating and detoxifying enzymes may play a role in determining an individual's susceptibility to ...
De Vivo, Immaculata, McGrath, Monica, Michaud, Dominique   +2 more
core   +1 more source

NAT2 gene polymorphism in bladder cancer: a study from North India

International Brazilian Journal of Urology, 2004
PURPOSE: This study was conducted to examine: 1) whether the NAT2 genotypes are risk factors for bladder cancer, 2) to study possible association of tobacco usage with NAT2 genotype of these patients.
Rama D. Mittal, Daya S.L. Srivastava, Anil Mandhani   +2 more
doaj   +1 more source

Neonatal Ontogeny of Murine Arylamine N-Acetyltransferases: Implications for Arylamine Genotoxicity [PDF]

Toxicological Sciences, 2003
Age-related changes in the expression of xenobiotic biotransformation enzymes can result in differences in the rates of chemical activation and detoxification, affecting responses to the therapeutic and/or toxic effects of chemicals. Despite recognition that children and adults may exhibit differences in susceptibility to chemicals, information about ...
Charlene A, McQueen, Binh, Chau
openaire   +2 more sources

Acetyl coenzyme A kinetic studies on N-acetylation of environmental carcinogens by human N-acetyltransferase 1 and its NAT1*14B variant

Frontiers in Pharmacology, 2022
N-acetyltransferase 1 (NAT1) is a xenobiotic metabolizing enzyme that uses acetyl coenzyme A (AcCoA) as a cofactor for N-acetylation of many carcinogens including aromatic amines and alkylanilines. NAT1 is characterized by single nucleotide polymorphisms
Mariam R. Habil, Mark A. Doll, David W. Hein   +2 more
doaj   +1 more source

Effect of gene-gene and gene-environment interactions associated with antituberculosis drug-induced hepatotoxicity [PDF]

, 2017
This study evaluated the association between environmental factors and genetic variations in enzymes that metabolize antituberculosis (anti-TB) drugs [arylamine N-acetyltransferase 2, cytochrome P450 2E1 (CYP2E1), glutathione S-transferase theta 1 (GSTT1)
Aidar, O., Caradonna, F., Castagnino, J., Chamorro, J., Costa, L., de Larra\uf1aga, G., Fr\uedas, A., Musella, R., Nogueras, M., Perez, A., Visca, M.   +10 more
core   +1 more source

Structure and Mechanism of Arylamine N-Acetyltransferases

Current Topics in Medicinal Chemistry, 2006
Arylamine N-acetyltransferases (NATs) are a family of phase II drug-metabolising enzymes which are important in the biotransformation of various aromatic and heterocyclic amines and hydroxylamines, arylhydrazines and arylhydrazides. NATs are present in a wide range of eukaryotes and prokaryotes.
Westwood, I M, Kawamura, A, Fullam, E, Russell, A J, Davies, S G, Sim, E   +5 more
openaire   +3 more sources

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting [PDF]

, 2016
This manuscript provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using
Agúndez, José A.G., Appell, Malin Lindqvist, Bell, Gillian C., Black, John Logan, Boukouvala, Sotiria, Bruckner, Carsten, Bruckner, Carsten, Bruford, Elspeth, Caudle, Kelly, Coulthard, Sally, Daly, Ann K., Del Tredici, Andria L., den Dunnen, Johan T, Drozda, Katarzyna, Everts, Robin, Flockhart, David, Freimuth, Robert, Gaedigk, Andrea, Hachad, Houda, Hartshorne, Toinette, Ingelman-Sundberg, Magnus, Kalman, Lisa V., Klein, Teri E., Lauschke, Volker M., Maglott, Donna R., McLeod, Howard L., McMillin, Gwendolyn A., Meyer, Urs A., Müller, Daniel J., Nickerson, Deborah A., Oetting, William S., Pacanowski, Michael, Pratt, Victoria M., Relling, Mary V., Roberts, Ali, Rubinstein, Wendy S., Sangkuhl, Katrin, Schwab, Matthias, Scott, Stuart A., Sim, Sarah C, Thirumaran, Ranjit K, Toji, Lorraine H., Tyndale, Rachel, van Schaik, Ron HN, Whirl-Carrillo, Michelle, Yeo, Kiang-Teck J, Zanger, Ulrich M.   +46 more
core   +1 more source

NAT2 global landscape: Genetic diversity and acetylation statuses from a systematic review

PLoS ONE, 2023
Arylamine N-acetyltransferase 2 has been related to drug side effects and cancer susceptibility; its protein structure and acetylation capacity results from the polymorphism’s arrays on the NAT2 gene.
Jorge E. Gutiérrez-Virgen, Maricela Piña-Pozas, Esther A. Hernández-Tobías, Lucia Taja-Chayeb, Ma. de Lourdes López-González, Marco A. Meraz-Ríos, Rocío Gómez   +6 more
doaj   +2 more sources