Results 91 to 100 of about 33,950 (227)
Highly selective electrochemical hydrogenation of alkynes: Rapid construction of mechanochromic materials [PDF]
, 2019 Electrochemical hydrogenation has emerged as an environmentally benign and operationally simple alternative to traditional catalytic reduction of organic compounds.
Ge, Haibo, Li, Bijin
core +1 more source
Dihydroquinazolinones by Titanocene‐Catalyzed Reductive Radical Addition to Quinazolinones
Chemistry – A European Journal, EarlyView.Tri‐ and tetracyclic dihydroquinazolinones or quinazolinones by titanocene catalysis: A highly diastereoselective and efficient reductive radical addition to quinazolinones enables an unprecedented entry to pharmaceutically relevant dihydroquinazolinones by avoiding the interception of radical intermediates prior to the slow radical addition.
Thomas Heinrichs +5 more
wiley +1 more source
Synthesis of 9-O-arylated berberines via copper-catalyzed CAr–O coupling reactions
Beilstein Journal of Organic Chemistry, 2019 Berberine is a widely used antimicrobial agent in clinic. However, a high dosage is often required due to its low lipophilicity and bioavailability. The current study explores the structural modifications of berberines with potentially lipophilic aryl ...
Qiaoqiao Teng +5 more
doaj +1 more source
Bayesian Optimization of Solvent‐Free Thermal Amidation via Reactive Extrusion
Chemistry – A European Journal, EarlyView.Thermal amidation between a carboxylic acid and an amine was successfully conducted in an extruder in the absence of solvent, coupling agent, or catalyst, relying on an adapted Bayesian Optimization protocol. Active pharmaceutical ingredient moclobemide was synthesized on a larger scale, achieving excellent yield and low Process Mass Intensity (PMI ...
Matthieu Lavayssiere +2 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 13, 23 March 2026.Manganese‐catalyzed enantioselective C(sp3)─H lactonization with hydrogen peroxide enables the direct desymmetrization of malonic monoesters and malonic acids, providing highly enantioenriched γ‐ and δ‐lactones (up to >99% ee) ABSTRACT Malonate derivatives are readily available starting materials widely employed in the synthesis of bioactive compounds.
Nikos Siakavaras +3 more
wiley +2 more sources
Catalytic enantioselective synthesis of quaternary carbon stereocentres. [PDF]
, 2014 Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single ...
Overman, Larry E, Quasdorf, Kyle W
core
Palladium-catalyzed C(sp^3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids [PDF]
, 2016 A Pd-catalyzed arylation of lactic acid employing 8-aminoquinoline as the directing group has been reported. The protocol is found to be compatible with a broad range of synthetically useful functional groups, thus providing a practical route to chiral β-
Chen, Kai +3 more
core +1 more source
Synthesis and Reactivity of Extremely Electron‐Poor Au(III) Complexes Bearing OTf− or NTf2− Ligands
Chemistry – A European Journal, EarlyView.A new family of electron‐poor Au(III) cations bearing bistriflimide or triflate ligands is reported. These cations can undergo direct C─H metalation with simple arenes to give mono‐aryl cations. Subsequent addition of simple halide sources allows for reductive elimination of aryl halides, formally from Ar─H and X−. ABSTRACT The synthesis and structural
Lachlan Barwise +6 more
wiley +1 more source
ChemSusChem, Volume 18, Issue 6, March 15, 2025.we have developed an electrochemical Ni−H catalyzed arylation coupling method of unactivated alkenes with aryl halides. The method displays broad functional group tolerance and proceeds under very mild conditions. Furthermore, aryl chlorides were also compatible substrates in this catalytic system. This conversion holds significant implications for the
Chao Xu, Ru‐Han A, Xiao‐Feng Wu
wiley +1 more source
Arylhydrazines: Convenient Homogeneous Reductants for Scalable Cross‐Coupling
Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.Reductive cross‐couplings enable efficient C–C bond formation but are limited by the heterogeneity of Zn or costly reagents like TDAE. We report arylhydrazines as inexpensive, convenient reductants for Ni‐catalyzed sp2–sp3 coupling of aryl halides and secondary alkyl iodides. Mechanistic studies support hydrazine‐mediated NiII reduction for a NiI/NiIII
Nils Kurig +5 more
wiley +2 more sources