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International Journal of Biological Macromolecules, 2018
AS1411 is a nucleolin-binding aptamer which attracted great interest as active targeting ligand for the selective delivery of therapeutic agents to tumour cells. In this work we selected three AS1411 derivatives 5'-conjugated with lipophilic tails and studied their properties in view of their application in liposomial formulations and/or lipid coated ...
Daniela Montesarchio +2 more
exaly +4 more sources
AS1411 is a nucleolin-binding aptamer which attracted great interest as active targeting ligand for the selective delivery of therapeutic agents to tumour cells. In this work we selected three AS1411 derivatives 5'-conjugated with lipophilic tails and studied their properties in view of their application in liposomial formulations and/or lipid coated ...
Daniela Montesarchio +2 more
exaly +4 more sources
Repurposing AS1411 for constructing ANM-PROTACs
Cell Chemical BiologyProteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands joined by a linker, enabling them to simultaneously bind with an E3 ligase and a protein of interest (POI) and trigger proteasomal degradation of the POI.
Zhuqian Wang +2 more
exaly +3 more sources
Aptamer AS1411 utilized for super-resolution imaging of nucleolin
Talanta, 2020Nucleolin (NCL) is a multifunctional protein that mainly localizes in the nucleolus and also distributes in the nucleoplasm, cytoplasm and cell membrane. Most studies focus on its biofunctions in cell activities and diseases, however, its detailed distribution and organization pattern in situ remains obscure.
Yingying, Jing +5 more
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Spectral properties and thermal stability of AS1411 G-quadruplex
International Journal of Biological Macromolecules, 2015G-quadruplexes are supramolecular structures of G-rich nucleic acid, formed by non-canonical base pairing in the presence of specific environmental inducers. These structures have been vastly considered in diagnostic and therapeutic applications. However, detailed information on structure, optical properties and thermal stability of G-quadruplex potent
Bijan Ranjbar +2 more
exaly +3 more sources
AS1411 aptamer for targetable photosensitizer delivery
2009 International Conference on Biomedical and Pharmaceutical Engineering, 2009A specialized G-quadruplex DNA aptamer with nucleolin targeting ability, AS1411, has been studied for cancer therapy. In this study, we report a novel delivery strategy for chemo-photodynamic combined treatment using AS1411 aptamer conjugated with tetra-(N-methyl-4-pyridyl)-porphine by intercalation and outside binding.
M. J. Shieh, Y. A. Shieh, P. S. Lai
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G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms
Biochimica Et Biophysica Acta - General Subjects, 2017AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic acids and which is present at high levels on the ...
Elsa Reyes-Reyes +2 more
exaly +3 more sources
Aptamer imaging with Cu-64 labeled AS1411: Preliminary assessment in lung cancer
Nuclear Medicine and Biology, 2014AS1411 is a 26-base guanine-rich oligonucleotide aptamer shown binding to surface nucleolin, a protein over-expressed in multiple cancer cells, thus AS1411 labeled with a PET isotope can be explored as a potential diagnostic imaging agent. Our objective was to perform preliminary biological characterization of (64)Cu-labeled AS1411 in vitro and in vivo.
Chin K Ng, John Trent, Tariq Malik
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Factors affecting the labeling yield of F‐18‐labeled AS1411
Journal of Labelled Compounds and Radiopharmaceuticals, 2007AbstractThe labeling of AS1411, a guanine (G)‐rich oligonucleotide (ON), conjugated with [18F]SFB was evaluated at different experimental conditions: ON concentration, base composition (G‐rich [AS1411] vs cytosine‐rich [CRO]), ON purity (desalted vs high‐pressure liquid chromatography (HPLC)‐purified) and buffers (tris‐HCl, sodium borate, and potassium
Chin K Ng, John Trent
exaly +2 more sources
Nucleolin Targeting AS1411 Modified Protein Nanoparticle for Antitumor Drugs Delivery
Molecular Pharmaceutics, 2013Over recent years, cell surface nucleolin as an anticancer target has attracted many researchers' attentions. To improve the antitumor efficacy, we developed a nucleolin targeted protein nanoparticle (NTPN) delivery system in which human serum albumin (HSA) was used as drug carrier and a DNA aptamer named AS1411, which had high affinity to nucleolin ...
Jinhui, Wu +5 more
openaire +2 more sources
AS1411 aptamer based nanomaterials: A novel approach for breast cancer therapy
International Journal of Biological MacromoleculesBreast cancer remains a leading cause of cancer-related mortality in women, accounting for 23.8 % of all female cancer cases. Existing therapies often lack tumor specificity, leading to severe off-target toxicity, dose-limiting side effects, and poor patient compliance. These limitations underscore the urgent need for innovative strategies that enhance
Wahab Shadma +2 more
exaly +3 more sources