Results 141 to 150 of about 2,541 (157)
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AS1411 derivatives as carriers of G-quadruplex ligands for cervical cancer cells
International Journal of Pharmaceutics, 2019Nucleic acid aptamers can specifically bind to target molecules on the cell membrane that mediate their entrance into the cells. Their small size, high binding affinity, specificity, good biocompatibility, stability and low immunogenicity make them ideal drug delivery systems for cancer therapy.
Joana Figueiredo +11 more
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Targeted delivery of melittin to cancer cells by AS1411 anti-nucleolin aptamer
Drug Development and Industrial Pharmacy, 2018Melittin, a small water-soluble cationic amphipathic α-helical linear peptide, consisted of 26 amino acids, is the honeybee venom major constituent. Several reports have proved the lytic and apoptotic effects of melittin in several cancerous cell lines.
Seyed Hossein, Rajabnejad +5 more
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Activity and Mechanism of Action of AS1411 in Acute Myeloid Leukemia Cells.
Blood, 2007Abstract AS1411 is a 26 base unmodified DNA aptamer which is currently in a Phase II clinical trial for the treatment of acute myeloid leukemia (AML) and will shortly enter a Phase II trial in renal cell carcinoma (RCC). AS1411 has previously been shown to have cytostatic (a result of arrest in S phase of the cell cycle) and cytotoxic ...
Daniel Fernandes +6 more
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AS1411 aptamer in melanoma therapy: Harnessing targeted strategies for precision treatment
Pathology - Research and PracticeMelanoma, the fifth most prevalent cancer type in both men and women, is characterized by substantial incidence and mortality rates. Melanoma treatment varies by stage and may include surgery, chemotherapy, immunotherapy, and targeted therapies. The AS1411 aptamer, which targets the overexpressed nucleolin protein in melanoma cells, has emerged as a ...
Monireh Askarzadeh +4 more
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In silico activity of AS1411 aptamer against nucleolin of cancer cells
2021The support of this work by the research council of Isfahan University of Medical Sciences under grant number 298096 and ethics code IR.MUI.RESEARCH.
Farahbakhsh, Z. +4 more
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Characterizing Oligonucleotide Uptake in Cultured Cells: A Case Study Using AS1411 Aptamer
2019Oligonucleotides can be designed or evolved to bind to specific DNA, RNA, protein, or small molecule targets and thereby alter the biological function of the target. The therapeutic potential of oligonucleotides targeted to intracellular molecules will depend largely on their ability to be taken up by the cells of interest, as well as their subsequent ...
Elsa M, Reyes-Reyes, Paula J, Bates
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The effect of AS1411 aptamer on anti-tumor effects of dendrimers containing SN38
Journal of Drug Delivery Science and Technology, 2022Kiana Sherkat Sadi +4 more
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[Effects of AS1411 on the apoptosis of taxol-resistant lung adenocarcinoma A549 cell].
Zhonghua yi xue za zhi, 2015To explore the effects of AS1411 on the apoptosis of taxol-resistant lung adenocarinoma A549 cell (A549/T cell).A549/T cells were treated with AS1411 at a concentration gradient of 0-20.0 µmol/L. The assays of methyl tolyl sulfide (MTS) and colony formation were used to detect the cellular vitality (absorbance value (A490 nm)) and proliferation.
Wei, Zhou +4 more
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AS1411: Development of an Anticancer Aptamer
2008Nigel Courtenay-Luck, Donald M. Miller
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