Results 91 to 100 of about 142,838 (307)

Biosynthesis of Kaitocephalin: A Neuroprotective Natural Product Featuring a Peptide‐Like yet Nonpeptidic Scaffold

Angewandte Chemie, EarlyView.
Kaitocephalin (KCP) is a neuroprotective fungal metabolite with a unique scaffold of amino acids linked via C–C bonds. Genome‐transcriptome analyses identified its biosynthetic gene cluster (kpb cluster) in Eupenicillium shearii. LC‐MS/MS profiling identified four new KCP‐related compounds.
Yukari Maeno, Taro Shiraishi, Naoya Saito, Jun‐ichi Maruyama, Kazuo Shin‐ya, Tomohisa Kuzuyama   +5 more
wiley   +2 more sources

Reactive Oxygen Species (ROS) Metabolism and Nitric Oxide (NO) Content in Roots and Shoots of Rice (Oryza sativa L.) Plants under Arsenic-Induced Stress

Agronomy, 2020
Arsenic (As) is a highly toxic metalloid for all forms of life including plants. Rice is the main food source for different countries worldwide, although it can take up high amounts of As in comparison with other crops, showing toxic profiles such as ...
Ernestina Solórzano, Francisco J. Corpas, Salvador González-Gordo, José M. Palma   +3 more
doaj   +1 more source

An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring

Advanced Science, EarlyView.
Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar, Marc A. Fernandez‐Yague, Adrien Bessaguet, Hosoowi Lee, Nicolas Giuseppone, Andrés J. García, Aránzazu del Campo   +6 more
wiley   +1 more source

Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions

Oléagineux, Corps gras, Lipides, 2006
Antioxidants of food origin (tocopherols, carotenoids, ascorbate, polyphenols) exert synergistic (tocopherols and ascorbate, carotenoids and ascorbate) or complementary (tocopherols ands carotenoids, ascorbate and polyphenols) antioxidant actions.
Léger Claude Louis
doaj   +1 more source

Ascorbate-mediated regulation of growth, photoprotection, and photoinhibition in Arabidopsis thaliana. [PDF]

, 2018
The requirements for ascorbate for growth and photosynthesis were assessed under low (LL; 250 µmol m-2 s-1) or high (HL; 1600 µmol m-2 s-1) irradiance in wild-type Arabidopsis thaliana and two ascorbate synthesis mutants (vtc2-1 and vtc2-4) that have 30%
Alexander V Ruban, Alexandra J Townsend, Aller, Aro, Asada, Awad, Baier, Barbara Karpinska, Bartoli, Bartoli, Bashandy, Bratt, Brwa Rasool, Christine H Foyer, Cohu, Conklin, de Simone, de Simone, Demmig-Adams, Dowdle, Dutilleul, Foyer, Foyer, Foyer, Foyer, Foyer, Gallie, Giacomelli, Greenberg, Guo, Heber, Heyneke, Horling, Jahns, Jahns, Kangasjärvi, Karpinska, Karpinska, Kerchev, Kiddle, Kromdijk, Lichtenthaler, Lim, Mano, Maruta, Meyer, Miyaji, Munné-Bosch, Müller-Moulé, Müller-Moulé, Neff, Noctor, Nurhayati Razak, Osmond, Page, Pastori, Pavet, Pignocchi, Powles, Queval, Rouhier, Ruban, Ruban, Sarah Alomrani, Shaikhali, Smirnoff, Smirnoff, Tamaoki, Taylor, Tedone, Tyystjärvi, Tyystjärvi, Tóth, Vanderauwera, Wang, Ware, Wheeler, William Plumb, Yabuta, Yin, Zechmann, Zhang, Zhang   +82 more
core   +2 more sources

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Excess Ascorbate is a Chemical Stress Agent against Proteins and Cells

Pharmaceuticals, 2020
Excess ascorbate (as expected in intravenous treatment proposed for COVID-19 management, for example) oxidizes and/or degrades hemoglobin and albumin, as evidenced by UV-vis spectroscopy, gel electrophoresis, and mass spectrometry.
Maria Lehene, Eva Fischer-Fodor, Florina Scurtu, Niculina D. Hădade, Emese Gal, Augustin C. Mot, Alina Matei, Radu Silaghi-Dumitrescu   +7 more
doaj   +1 more source

The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria [PDF]

, 1987
The precursor of the mitochondrial inner membrane protein ADP/ATP carrier is cytoplasmically synthesized without an amino-terminal peptide extension. We constructed a truncated precursor lacking the 103 amino acids from the amino terminus (about a third ...
Hoeben, Peter, Neupert, Walter, Pfanner, Nikolaus, Tropschug, Maximilian   +3 more
core  

Studies on Ascorbic Acid. VI

Journal of the agricultural chemical society of Japan, 1938
5mgのAscorbin酸の37±1°に於ける自己酸化に對しVitamin A原液(100,000 I.U.)を0.0～0.2cc作用せしむる時0.0～0.0005ccまでは自己酸化抑制作用は發現せず, 0.001ccに於いて漸く發現し而して0.12ccまではVitamin Aの作用量と共に抑制作用は増大し0.12ccに於いて最大點に達し0.14cc以上に於いては抑制作用は消滅し酸化促進作用と化し而も此の作用は量比的である.但し本實驗に於てはVitamin AのAceton溶液を用ゐたから實驗値に對して幾分の誤差はまぬかれないであらう.
openaire   +8 more sources