Results 111 to 120 of about 21,778 (164)
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Journal of Biomolecular Structure and Dynamics, 1998
Ascorbic acid and divalent iron salts have been widely used to investigate the effects of reactive oxygen species in different biological targets such as nucleic acids, proteins and lipids. This study was designed to examine the interaction of yeast RNA with vitamin C in aqueous solution at physiological pH with drug/RNA(P)(P=phosphate) molar ratios of
M C, Djoman +3 more
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Ascorbic acid and divalent iron salts have been widely used to investigate the effects of reactive oxygen species in different biological targets such as nucleic acids, proteins and lipids. This study was designed to examine the interaction of yeast RNA with vitamin C in aqueous solution at physiological pH with drug/RNA(P)(P=phosphate) molar ratios of
M C, Djoman +3 more
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The stability of choline ascorbate
Journal of Basic and Clinical Physiology and Pharmacology, 2008The stability of choline ascorbate was studied considering concentration, temperature, and pH of the drug solution. Our results revealed that choline ascorbate is almost fully stable with respect to these parameters. Practically no loss was observed when 3 x l0(-1) (50%) drug solution is preserved in the refrigerator, at ambient temperature, or at 37 ...
D O, Yillar +3 more
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Journal of Comparative Physiology B, 1990
Ascorbate metabolism was analyzed in fasted common carp and carp offered diets lacking ascorbic acid or supplemented with ascorbic acid (AA) or ascorbic sulfate (AS). Ascorbic acid and ascorbic sulfate were analyzed in the contents collected from various parts of the digestive tract. The major site of the dietary ascorbate absorption was located in the
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Ascorbate metabolism was analyzed in fasted common carp and carp offered diets lacking ascorbic acid or supplemented with ascorbic acid (AA) or ascorbic sulfate (AS). Ascorbic acid and ascorbic sulfate were analyzed in the contents collected from various parts of the digestive tract. The major site of the dietary ascorbate absorption was located in the
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Biochemical and Biophysical Research Communications, 2010
Ascorbic acid (AA) is a common culture medium and dietary supplement. While AA is most commonly known for its antioxidant properties, it is also known to function as a pro-oxidant under select conditions. However, the complexity and often unknown composition of biological culture systems makes prediction of AA behaviour in supplemented cultures ...
Osiecki, Michael +4 more
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Ascorbic acid (AA) is a common culture medium and dietary supplement. While AA is most commonly known for its antioxidant properties, it is also known to function as a pro-oxidant under select conditions. However, the complexity and often unknown composition of biological culture systems makes prediction of AA behaviour in supplemented cultures ...
Osiecki, Michael +4 more
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Ascorbate compartmentalization in the CNS
Neurotoxicity Research, 1999Ascorbic acid, found physiologically as the ascorbate anion, is an abundant water-soluble antioxidant. It is concentrated in the intracellular compartment of all tissues in the body. The CNS has particularly high levels of ascorbate. Recent data from this laboratory indicate that ascorbate is distinctly compartmentalized between neurons and glia, with ...
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Ascorbate status and xerostomia
Medical Hypotheses, 1992Xerostomia, the subjective feeling of dry mouth, affects millions of people particularly the elderly. It is invariably associated with hypofunction of the salivary glands. The amount, rate of secretion, and composition of saliva are regulated by both sympathetic and parasympathetic receptor systems whose stimulation transmits signals through ...
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The regulation of ascorbate biosynthesis
Current Opinion in Plant Biology, 2016We review the regulation of ascorbate (vitamin C) biosynthesis, focusing on the l-galactose pathway. We discuss the regulation of ascorbate biosynthesis at the level of gene transcription (both repression and enhancement) and translation (feedback inhibition of translation by ascorbate concentration) and discuss the eight proteins that have been ...
Sean Bulley, William Laing
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Nature, 1963
ASCORBIC acid is found in all green plants, although its concentration may vary greatly. Probably the largest concentration recorded is in the endocarp of the walnut, Juglans regia, which contains between 2 and 3 per cent of the fresh weight. The smallest concentration recorded is possibly that in the vegetable marrow, Cucurbita ovifera, 0.002 per cent
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ASCORBIC acid is found in all green plants, although its concentration may vary greatly. Probably the largest concentration recorded is in the endocarp of the walnut, Juglans regia, which contains between 2 and 3 per cent of the fresh weight. The smallest concentration recorded is possibly that in the vegetable marrow, Cucurbita ovifera, 0.002 per cent
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A unique function for ascorbate
Medical Hypotheses, 1991Vitamin C is a reducing substance, an electron donor. When vitamin C donates its two high-energy electrons to scavenge free radicals, much of the resulting dehydroascorbate is re-reduced to vitamin C and therefore used repeatedly. Conventional wisdom is correct in that only small amounts of vitamin C are necessary for this function because of its ...
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Bioactivation of Nitroglycerin by Ascorbate
Molecular Pharmacology, 2007Bioactivation of nitroglycerin (GTN) into an activator of soluble guanylate cyclase (sGC) is essential for the vasorelaxant effect of the drug. Besides several enzymes that catalyze GTN bioactivation, the reaction with cysteine is the sole nonenzymatic mechanism known so far. Here we show that a reaction with ascorbate results in GTN bioactivation.
Alexander, Kollau +6 more
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