Results 91 to 100 of about 9,601 (189)

Enhancing DNA immunization by targeting ASFV antigens to SLA-II bearing cells

Vaccine, 2011
One of the main criticisms to DNA vaccines is the poor immunogenicity that they confer on occasions, at least in large animals. Confirming this theory, immunization with plasmid DNA encoding two African swine fever virus genes in frame (pCMV-PQ), failed in inducing detectable immune responses in pigs, while it was successful in mice.
Argilaguet, JM, Pérez-Martín, E, Gallardo, C, Salguero, FJ, Borrego, B, Lacasta, A, Accensi, F, Díaz, I, Nofrarías, M, Pujols, J, Blanco, E, Pérez-Filgueira, M, Escribano, JM, Rodríguez, F   +13 more
openaire   +6 more sources

Study on the role of the sylvatic cycle of African swine fever in Senegal [PDF]

, 2009
It is generally believed that African swine fever (ASF) virus in Sub-Saharan Africa is maintained in nature by warthogs (Phacochoerus africanus) and soft ticks from the genus Ornithodoros (Penrith et al., 2004).
Akakpo, A.J., Blanco, Esther, Etter, Eric, Jori, Ferran, Perez, R., Roger, François, Vial, Laurence   +6 more
core  

Is Ornithodoros erraticus able to transmit the Georgia2007/1 African Swine Fever virus isolate to domestic pigs? [PDF]

, 2015
Objective: African swine fever, one of the most devastating diseases affecting wild and domestic swine, is due to a large DNA virus, only member of the Asfarviridae family.
Bernard, Jennifer, Boinas, Fernando, Hutet, Evelyne, Le Potier, Marie-Frédérique, Michaud, Vincent, Paboeuf, Frédéric, Vial, Laurence   +6 more
core  

African swine fever virus transmission cycles in Central Europe: evaluation of wild boar-soft tick contacts through detection of antibodies against Ornithodoros erraticus saliva antigen. [PDF]

, 2016
BACKGROUND African swine fever (ASF) is one of the most complex viral diseases affecting both domestic and wild pigs. It is caused by ASF virus (ASFV), the only DNA virus which can be efficiently transmitted by an arthropod vector, soft ticks of the ...
Beer, Martin, Blome, Sandra, Mur, Lina, Oleaga, Ana, Pietschmann, Jana, Pérez Sánchez, Ricardo, Sánchez-Vizcaíno, José Manuel   +6 more
core   +4 more sources

Kinetics of Viral Genome Distribution in Swine Peripheral Lymphoid Organs Following Oronasal Infection with Attenuated African swine fever virus strains

Viruses
African swine fever (ASF) continues to spread across the globe, causing a severe impact on the swine industry. Passive surveillance based on testing dead pigs is one of the most effective methods for early detection of ASF incursions.
Kalhari Goonewardene, Carissa Embury-Hyatt, Estella Moffat, Aruna Ambagala   +3 more
doaj   +1 more source

mRNA:guanine- 7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships [PDF]

, 2001
Background The 5'-terminal cap structure plays an important role in many aspects of mRNA metabolism. Capping enzymes encoded by viruses and pathogenic fungi are attractive targets for specific inhibitors.
Radlinska Monika, Feder Marcin, Bujnicki Janusz M, Rychlewski Leszek   +3 more
core   +2 more sources

Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010

Pathogens
We have previously reported that the recombinant African Swine Fever (ASF) vaccine candidate ASFV-G-Δ9GL/ΔUK efficiently induces protection in domestic pigs challenged with the virulent strain Georgia 2010 (ASFV-G).
Elizabeth Ramirez-Medina, Ayushi Rai, Nallely Espinoza, Edward Spinard, Ediane Silva, Leeanna Burton, Jason Clark, Amanda Meyers, Alyssa Valladares, Lauro Velazquez-Salinas, Cyril G. Gay, Douglas P. Gladue, Manuel V. Borca   +12 more
doaj   +1 more source

The African swine fever virus gene MGF_360-4L inhibits interferon signaling by recruiting mitochondrial selective autophagy receptor SQSTM1 degrading MDA5 antagonizing innate immune responses

mBio
Multigene family (MGF) 360 genes, which are African swine fever virus (ASFV) virulence genes, primarily target key host immune molecules to suppress host interferon (IFN) production and interferon-stimulated gene (ISG) transcription, impairing host ...
Hualin Sun, Jifei Yang, Zhonghui Zhang, Mengli Wu, Zhancheng Tian, Ying Liu, Xiaoqiang Zhang, Jianhao Zhong, Songlin Yang, Yikang Chen, Jianxun Luo, Guiquan Guan, Hong Yin, Qingli Niu   +13 more
doaj   +1 more source

Control of African swine fever virus by siRNA [PDF]

, 2007
African Swine Fever (ASF) is a highly contagious, viral disease of pigs caused by an Asfivirus. It can cause up to 100% of mortality in domestic pigs and European wild boars, although varying degrees of virulence have been shown.
Albina, Emmanuel, Keita, D.
core  

Protective Efficacy of Live-Attenuated ASFV Vaccine Strains against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam

African swine fever virus (ASFV) continues to spread globally causing severe economic losses to the pig farmers. Vietnam licensed two live attenuated vaccines based on the ASFV strains ASFV-G-ΔI177L and ASFV-G-ΔMGF, to control the ongoing ASF outbreaks.
Nguyen Van Diep, Nguyen Van Duc, Nguyen Thi Ngoc, Dang Xuan Vu, Tran Ngoc Tiep, Viet Dung Nguyen, Thi Tam Than, Dustin Maydaniuk, Kalhari Goonewardene, Aruna Ambagala, Van Phan Le   +10 more
openaire   +1 more source