Results 61 to 70 of about 10,002 (242)

Screening and identification of the dominant antigens of the African swine fever virus

Frontiers in Veterinary Science, 2023
African swine fever is a highly lethal contagious disease of pigs for which there is no vaccine. Its causative agent African swine fever virus (ASFV) is a highly complex enveloped DNA virus encoding more than 150 open reading frames.
Zhaoyang Xu, Zhaoyang Xu, Yifan Hu, Junbo Li, Junbo Li, Ancheng Wang, Xin Meng, Xin Meng, Lingchao Chen, Jianchao Wei, Wu Tong, Ning Kong, Lingxue Yu, Hai Yu, Tongling Shan, Guangzhi Tong, Guihua Wang, Hao Zheng, Hao Zheng   +18 more
doaj   +1 more source

Infection Characteristics and Transcriptomics of African Swine Fever Virus in Bama Minipigs

Microbiology Spectrum, 2022
Animal experiments on African swine fever virus (ASFV) are vital to the study of ASFV; however, ASFV can only infect pigs, and animal experiments need to be performed in animal biosafety level 3 (ABSL-3) laboratories, meaning that many small ABSL-3 ...
Changjie Lv, Jingyu Yang, Li Zhao, Chao Wu, Chao Kang, Qiang Zhang, Xiaomei Sun, Xi Chen, Zhong Zou, Meilin Jin   +9 more
doaj   +1 more source

African swine fever virus assembles a single membrane derived from rupture of the endoplasmic reticulum [PDF]

, 2016
Collective evidence argues that two members of the nucleocytoplasmic large DNA viruses (NCLDVs) acquire their membrane from open membrane intermediates, postulated to be derived from membrane rupture.
Andrés, Germán, Hoppe, S., Kolovou, Androniki, Krijnse Locker, J., Salas, María Luisa, Suárez, Cristina, Walther, P.   +6 more
core   +1 more source

Regulation of antiviral immune response by African swine fever virus (ASFV)

Virologica Sinica, 2022
African swine fever (ASF) is a highly contagious and acute hemorrhagic viral disease with a high mortality approaching 100% in domestic pigs. ASF is an endemic in countries in sub-Saharan Africa. Now, it has been spreading to many countries, especially in Asia and Europe.
Xiaojie Zheng, Shengming Nie, Wen-Hai Feng   +2 more
openaire   +2 more sources

Generation and characterization of a monoclonal antibody against an African swine fever virus protein encoded by the A137R gene

Frontiers in Veterinary Science, 2023
The ongoing African swine fever (ASF) pandemic continues to have a major impact on global pork production and trade. Since ASF cannot be distinguished from other swine hemorrhagic fevers clinically, ASF-specific laboratory diagnosis is critical. Thus ASF
Carissa Embury-Hyatt, Estella Moffat, Dmytro Zhmendak, Cassidy N. G. Erdelyan, Brad Collignon, Kalhari Goonewardene, Aruna Ambagala, Ming Yang   +7 more
doaj   +1 more source

Lyophilization of ASFV vaccine candidate ASFV-G-ΔI177L offers long term stability

Scientific Reports
AbstractFor over a century African swine fever (ASF) has been causing outbreaks leading to devastating losses for the swine industry. The current pandemic of ASF has shown no signs of stopping and continues to spread causing outbreaks in additional countries.
Nallely Espinoza, Edward Spinard, Ayushi Rai, Elizabeth Ramirez-Medina, Alyssa Valladares, Amanda Meyers, Manuel V. Borca, Douglas P. Gladue   +7 more
openaire   +3 more sources

Artificial Insemination as an Alternative Transmission Route for African Swine Fever Virus

Pathogens, 2022
The rapid spread of the African swine fever virus (ASFV), causing severe disease with often high fatality rates in Eurasian suids, prevails as a threat for pig populations and dependent industries worldwide.
Virginia Friedrichs, Darwin Reicks, Tobias Hasenfuß, Elisabeth Gerstenkorn, Jeffrey J. Zimmerman, Eric A. Nelson, Tessa Carrau, Paul Deutschmann, Julia Sehl-Ewert, Hanna Roszyk, Martin Beer, Jane Christopher-Hennings, Sandra Blome   +12 more
doaj   +1 more source

African Swine Fever Virus (ASFV) Indirect ELISA Test Based on the Use of the Soluble Cytoplasmic Semi- purified Antigen (ASFV CP-Ag)

, 2022
The present chapter describes a simple and economic indirect enzyme immunoassay (ELISA ) for African swine fever virus (ASFV) antibody detection based on the use of the soluble cytoplasmic fraction of ASFV-infected monkey stable cells (MS). The soluble antigen proteins of ASFV-infected cells are separated by sucrose precipitation centrifugation, and ...
Carmina, Gallardo, Nieto, R, Arias, M
openaire   +3 more sources

The African Swine Fever Virus with MGF360 and MGF505 Deleted Reduces the Apoptosis of Porcine Alveolar Macrophages by Inhibiting the NF-κB Signaling Pathway and Interleukin-1β

Vaccines, 2021
African swine fever virus (ASFV) poses serious threats to the swine industry. The mortality rate of African swine fever (ASF) is 100%, and there is no effective vaccine currently available.
Qi Gao, Yunlong Yang, Weipeng Quan, Jiachen Zheng, Yizhuo Luo, Heng Wang, Xiongnan Chen, Zhao Huang, Xiaojun Chen, Runda Xu, Guihong Zhang, Lang Gong   +11 more
doaj   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source