Results 81 to 90 of about 9,601 (189)

Evaluation of the risk factors contributing to the African swine fever occurrence in Sardinia, Italy [PDF]

, 2015
This study assesses the relation between hypothesized risk factors and African swine fever virus (ASFV) distribution in Sardinia (Italy) after the beginning of the eradication program in 1993, using a Bayesian multivariable logistic regression mixed ...
Feliziani, Francesco, Martínez López, Beatriz, Mur, Lina, Perez, Andres M, Rolesu, Sandro, Sánchez-Vizcaíno, José Manuel   +5 more
core   +4 more sources

MHC Class II–Alpha Chain Knockout Mice Support Increased Viral Replication That Is Independent of Their Lack of MHC Class II Cell Surface Expression and Associated Immune Function Deficiencies

, 2015
MHCII molecules are heterodimeric cell surface proteins composed of an α and β chain. These molecules are almost exclusively expressed on thymic epithelium and antigen presenting cells (APCs) and play a central role in the development and function of CD4
Alsharifi, Mohammed, Bettadapura, Jayaram, Koskinen, Aulikki, Müllbacher, Arno, Wijesundara, Danushka K.   +4 more
core   +1 more source

When ASFV Infection Meets the cGAS‐STING Signaling Pathway

Transboundary and Emerging Diseases
The African swine fever virus (ASFV) has the ability to infect both wild boars and domestic pigs, regardless of their breeds or ages, often resulting in a mortality rate of 100%. Host innate immunity is the most important defense weapon against invasion of pathogenic microbial infection.
Songbiao Chen, Ke Shang, Ying Wei, Jian Chen, Zuhua Yu, Lei He, Ke Ding   +6 more
openaire   +2 more sources

ASFV infection induces macrophage necroptosis and releases proinflammatory cytokine by ZBP1-RIPK3-MLKL necrosome activation

Frontiers in Microbiology
African swine fever (ASF) is an infectious disease characterized by hemorrhagic fever, which is highly pathogenic and causes severe mortality in domestic pigs. It is caused by the African swine fever virus (ASFV).
Dajun Zhang, Yu Hao, Xing Yang, Xijuan Shi, Dengshuai Zhao, Lingling Chen, Huanan Liu, Zixiang Zhu, Haixue Zheng   +8 more
doaj   +1 more source

Identification and utility of innate immune system evasion mechanisms of ASFV

Virus Research, 2013
The interferon (IFN) system is an early innate anti-virus host defense mechanism that takes place shortly after entry of the pathogen and long before the onset of adaptive immunity. Thus, African swine fever virus (ASFV), as an acute and persistent virus in pigs, is predicted to have evolved multiple genes for the manipulation and evasion of interferon.
Sílvia, Correia, Sónia, Ventura, Robert Michael, Parkhouse   +2 more
openaire   +2 more sources

African swine fever: a global view of the current challenge [PDF]

, 2015
African Swine Fever (ASF) is an important contagious haemorrhagic viral disease affecting swine whose notification is mandatory due to its high mortality rates and the great sanitary and socioeconomic impact it has on international trade in animal and ...
Ma Carmen Gallardo, Ana de la Torre Reoyo, Jovita Fernández-Pinero, Irene Iglesias, Ma Jesús Muñoz, Ma Luisa Arias   +5 more
core   +1 more source

Evaluation in Swine of a Recombinant African Swine Fever Virus Lacking the MGF-360-1L Gene

Viruses, 2020
The African swine fever (ASF) pandemic is currently affecting pigs throughout Eurasia, resulting in significant swine production losses. The causative agent, ASF virus (ASFV), is a large, structurally complex virus with a genome encoding more than 160 ...
Elizabeth Ramirez-Medina, Elizabeth A. Vuono, Ayushi Rai, Sarah Pruitt, Ediane Silva, Lauro Velazquez-Salinas, James Zhu, Douglas P. Gladue, Manuel V. Borca   +8 more
doaj   +1 more source

The role of wild hosts (wild pigs and ticks) in the epidemiology of African swine fever in West Africa and Madagascar [PDF]

, 2007
African swine fever (ASF) adversely affects pig production in Sub-Saharan Africa. In southern and eastern Africa, the virus is maintained in populations of wild pigs (Phacochoerus africanus) and soft ticks from the Genus Ornithodoros.
Akakpo, J., Costard, Solenne, Etter, Eric, Jori, Ferran, Le Glaunec, Gaële, Perez, R., Ravaomanana, Julie, Roger, François, Sarr, J., Vial, Laurence   +9 more
core  

Pathology of porcine peripheral white blood cells during infection with African swine fever virus [PDF]

, 2012
Background African swine fever virus (ASFV) is the causative agent of African swine fever (ASF) that is the significant disease of domestic pigs. Several studies showed that ASFV can influence on porcine blood cells in vitro.
Zaven Karalyan, Hovakim Zakaryan, Hranush Arzumanyan, Khachik Sargsyan, Henrik Voskanyan, Lina Hakobyan, Liana Abroyan, Aida Avetisyan, Elena Karalova   +8 more
core   +2 more sources

Identification of cepharanthine as an effective inhibitor of African swine fever virus replication

Emerging Microbes and Infections
African swine fever virus (ASFV) causes highly contagious swine disease, African swine fever (ASF), thereby posing a severe socioeconomic threat to the global pig industry and underscoring that effective antiviral therapies are urgently required.
Chuanxiang Qi, Jiyoung Lee, Yongqiang Zhang, Huan Chen, Jiaxuan Lv, Zhenzhong Wang, Jinming Li, Xiaodong Wu, Yong-Sam Jung, Zhiliang Wang, Yingjuan Qian   +10 more
doaj   +1 more source