Results 141 to 150 of about 2,537 (176)
Some of the next articles are maybe not open access.
Biological activity of des-(Asp1, Arg2, Val3)-angiotensin II in man
Life Sciences, 1983Abstract When des-(Asp 1 , Arg 2 , Val 3 )-angiotensin II was infused iv at rates of 308–5,550 pmol/kg·min for 10–120 min into 5 normal men and 2 patients with Bartter's syndrome, no significant change was observed in blood pressure (BP), plasma renin activity (PRA) or plasma aldosterone (PA), and the lowest dose did not inhibit a captopril-induced ...
T, Kono +6 more
openaire +2 more sources
The ASP1 gene of Saccharomyces cerevisiae, encoding the intracellular isozyme of l-asparaginase
Gene, 1994Saccharomyces cerevisiae produces two L-asparaginases (ASPs), intracellular ASP I and cell-wall ASP II. In this report, the ASP-I-encoding gene, ASP1, has been identified by homology cloning based on the structures of ASPs from other organisms. Its deduced protein product has a subunit M(r) of 41,414, and shows substantial sequence homology to the ...
K, Sinclair, J P, Warner, D T, Bonthron
openaire +2 more sources
Clinical Science, 1978
1. Immunoreactive angiotensin II was measured in cerebrospinal fluid of four normal dogs. 2. The migration of this immunoreactive angiotensin II on polyacrylamide-slab gel electrophoresis was identical with the migration of the heptapeptide, Des-Asp1-angiotensin II, in each case. 3.
J S, Hutchinsón +3 more
openaire +2 more sources
1. Immunoreactive angiotensin II was measured in cerebrospinal fluid of four normal dogs. 2. The migration of this immunoreactive angiotensin II on polyacrylamide-slab gel electrophoresis was identical with the migration of the heptapeptide, Des-Asp1-angiotensin II, in each case. 3.
J S, Hutchinsón +3 more
openaire +2 more sources
INHIBITION OF ANGIOTENSIN III ACTION BY DES-ASP1-,ILEU8-ANGIOTENSIN II IN MAN
Acta Endocrinologica, 1978ABSTRACT In 5 normal men intravenous infusion of 600 ng/kg/min of des-asp1-,ileu8-angiotensin II (AIIIA) inhibited a rise in blood pressure as well as increase in plasma aldosterone caused by an intravenous infusion of 20 or 100 ng/kg/min of des-asp1-angiotensin II (angiotensin III, AIII). This result and our previous study on simultaneous infusions of
T, Kono +5 more
openaire +4 more sources
Identification and characterization of Schizosaccharomyces pombe asp1(+), a gene that interacts with mutations in the Arp2/3 complex and actin. [PDF]
Genetics, 1999 Abstract The Arp2/3 complex is an essential component of the actin cytoskeleton in yeast and is required for the movement of actin patches. In an attempt to identify proteins that interact with this complex in the fission yeast Schizosaccharomyces pombe, we sought high-copy suppressors of the S.
Ryoma Ohi +2 more
exaly +3 more sources
Evidence for the Existence of des-Asp1-Angiotensin II in Human Uterine and Adrenal Tissues*
The Journal of Clinical Endocrinology & Metabolism, 1985Renin is present in various tissues outside the kidney. In contrast, the levels of angiotensins (ANG), the active products of the renin-angiotensin system, have not been thoroughly evaluated in tissues. In this study, we demonstrated the presence of immunoreactive (ir) ANG I and ANG II in various human tissues by RIA.
MITSUHIDE NARUSE +10 more
openaire +2 more sources
In vivo conversion of [des-Asp1]-angiotensin I to [des-Asp1]-angiotensin II in conscious sheep.
Clinical and experimental pharmacology & physiology. Supplement, 19831. A method is described for the measurement of [des-Asp1]-angiotensin I (ANG I 1/2) in blood. 2. Exogenous ANG I 1/2 was rapidly metabolized in conscious sodium replete sheep. 3. Inhibition of angiotensin converting enzyme activity by SQ 14 225 (captopril) abolished the production of angiotensin III (ANG III) and the pressor response to infused ANG I ...
D T, Fei +3 more
openaire +1 more source
Evidence that des-Asp1 angiotensin II mediates the renin-angiotensin response.
Circulation Research, 1976Studies were undertaken to compare and evaluate the influence of angiotensin II and its heptapeptide fragments, des-Asp-1-angiotensin II, at various receptor sites for angiotensin in both dogs and rats. Receptor sites evaluated were those which are found in the glomerulosa, reticularis, and fasiculata of the adrenal cortex, in the renal arterioles and ...
R H, Freeman +3 more
openaire +2 more sources
Journal of Neurogenetics, 1998
Previous studies showed an association between the Ahr locus on Chr 12 and a major gene, Asp1, that influences susceptibility to audiogenic seizures (AGS) in mice. Although the association was thought to involve close linkage, a pleiotropic effect of the Ahr locus on AGS susceptibility was not excluded.
L, DiRocco +4 more
openaire +2 more sources
Previous studies showed an association between the Ahr locus on Chr 12 and a major gene, Asp1, that influences susceptibility to audiogenic seizures (AGS) in mice. Although the association was thought to involve close linkage, a pleiotropic effect of the Ahr locus on AGS susceptibility was not excluded.
L, DiRocco +4 more
openaire +2 more sources
[DES-ASP1] angiotensin II in the sheep: Blood levels and its effect on plasma renin concentration
Life Sciences, 1980Abstract The present study describes an improved method for measuring angiotensin III in arterial blood. This was accomplished by SE-sephadex column to separate angiotensin II from angiotensin III prior to radioimmunoassay. The arterial concentration of angiotensin III measured before and after 24 to 48 hours sodium depletion by acute cannulation of ...
D T, Fei +4 more
openaire +2 more sources