Results 131 to 140 of about 2,537 (176)

Renal and adrenal responses to [des-Asp1]angiotensin I in the dog

open access: yesAmerican Journal of Physiology, 1978
There is evidence for the endogenous generation of [des-Asp1]angiotensin II (AIII) from a nonapeptide precursor, [des-Asp1]angiotensin I ([des-Asp1]AI). In the present study, the effects of equipressor doses of exogeneously administered [des-Asp1]AI and AIII on renal function and plasma aldosterone concentration were compared. Intravenous infusion of [
R H Freeman, Mahesh C Khosla, J O Davis
exaly   +4 more sources

Transfer and Expression of an Artificial Storage Protein (ASP1) Gene in Cassava (Manihot Esculenta Crantz)

open access: yesTransgenic Research, 2003
In order to increase the nutritional quality of cassava storage roots, which contain up to 85% starch of their dry weight, but are deficient in protein, a synthetic ASP1 gene encoding a storage protein rich in essential amino acids (80%) was introduced into embryogenic suspensions of cassava via Agrobacterium-mediated gene transfer.
Wilhelm Gruissem   +2 more
exaly   +5 more sources

Saturation of the Secretory Pathway by Overexpression of a Hookworm (Necator americanus) Protein (Na-ASP1)

open access: yesMethods in Molecular Biology, 2007
Human hookworm infection is one of the most significant parasitic infections, and a leading global cause of anemia and malnutrition of adults and children in rural areas of the tropics and subtropics. Necator americanus secretory protein (Na-ASP1), which is a potential vaccine candidate against hookworm infections, has been expressed in Pichia pastoris.
Peter J. Hotez, Bin Zhan, Mehmet İnan
exaly   +4 more sources

The PPIP5K Family Member Asp1 Controls Inorganic Polyphosphate Metabolism in S. pombe [PDF]

open access: yesJournal of Fungi (Basel, Switzerland), 2021
Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by phosphoanhydride bonds.
Ursula Fleig, Adolfo Saiardi
exaly   +2 more sources
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Synthesis and evaluation of [des-Asp1]angiotensin I as a precursor for [des-Asp1]angiotensin II (angiotensin III)

Journal of Medicinal Chemistry, 1975
The nonapeptide [des-Asp1]angiotensin I (IV), synthesized by Merrifield's solid-phase procedure, was tested as a possible substrate for the converting enzymes from porcine lung and plasma. IV, [des-Asp1]angiotensin II (III), [des-(Asp1,Arg2)]angiotensin II (V), [des-(Asp1,Arg2,Val3)]angiotensin II (VI), [Sar1,Ile8]angiotensin II (VII), and [des-Asp1 ...
M J Peach, M C Khosla, F M Bumpus
exaly   +3 more sources

ASP1 (BACE2) Cleaves the Amyloid Precursor Protein at the β-Secretase Site

Molecular and Cellular Neurosciences, 2000
Sequential proteolytic processing of the Amyloid Precursor Protein (APP) by beta- and gamma-secretases generates the 4-kDa amyloid (A beta) peptide, a key component of the amyloid plaques seen in Alzheimer's disease (AD). We and others have recently reported the identification and characterisation of an aspartic proteinase, Asp2 (BACE), as beta ...
Christopher Southan   +2 more
exaly   +3 more sources

A comparative study of two structurally related analogs of Asp1-Ile5-angiotensin II

Naunyn-Schmiedeberg's Archives of Pharmacology, 1974
Two new synthetic analogs of Asp1-Ile5-angiotensin II, Sar1-Ile5-Ile8-angiotensin II and (N,N-dimethyl) Gly1-Ile5-Ile8-angiotensin II which are chemically related, have a potent competitive antagonistic action against Asp1-β-amid-Val5-angiotensin II on the rabbit isolated aorta, rat ascending colon, isolated perfused heart of cat and in vivo on the ...
R K Türker
exaly   +3 more sources

Tetrapod-Type [Asp1] Angiotensin Is Present in a Holostean Fish,Amia calva

General and Comparative Endocrinology, 1998
The renin-angiotensin system has been identified in various vertebrates, from elasmobranchs to mammals. Tetrapod (amphibians to mammals) angiotensin (ANG) has Asp at the N-terminus, but Asp is replaced by Asn in elasmobranch and teleost fish. ANG I has been isolated from incubates of plasma and kidney extracts of the bowfin Amia calva, a holostean fish,
Y, Takei   +4 more
openaire   +2 more sources

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