Results 61 to 70 of about 182,632 (352)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

High-pressure Raman study of L-alanine crystal

, 2000
Pressure-dependent Raman scattering studies in the range 0.0 -- 32 kbar were carried out in L-alanine in order to investigate its external mode phonon spectra in relation to the phase transitions in the crystal.
A.J.D. Moreno, A.M.R. Teixeira, A.P. Ayala, Adamowicz, F.E.A. Melo, Forss, J. Mendes Filho, J.M. Sasaki, Jackson, Jonsson, Kwok, Lemanov, Loh, Machida, Migliori, Moreno, P.T.C. Freire, Ramanadham, Shoemaker, Silva, Simpson, Wang   +21 more
core   +2 more sources

Identifying conformational changes with site-directed spin labeling reveals that the GTPase domain of HydF is a molecular switch [PDF]

, 2017
[FeFe]-hydrogenases catalyse the reduction of protons to hydrogen at a complex 2Fe[4Fe4S] center called H-cluster. The assembly of this active site is a multistep process involving three proteins, HydE, HydF and HydG.
Acquasaliente, Laura, Bortolus, Marco, Carbonera, Donatella, Costantini, Paola, DE FILIPPIS, Vincenzo, DE ROSA, Edith, Doni, Davide, Galazzo, Laura, Maso, Lorenzo   +8 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Asparagine Synthesis During Tobacco Leaf Curing

Plants, 2019
Senescence is a genetically controlled mechanism that modifies leaf chemistry. This involves significant changes in the accumulation of carbon- and nitrogen-containing compounds, including asparagine through the activity of asparagine synthetases.
Lucien Bovet, Cecilia Cheval, Aurore Hilfiker, James Battey, Delphine Langlet, Herve Broye, Joanne Schwaar, Pierrick Ozelley, Gerhard Lang, Nicolas Bakaher, Helene Laparra, Simon Goepfert   +11 more
doaj   +1 more source

Role of asparagine biosynthesis pathway in Siniperca chuatsi rhabdovirus proliferation

Frontiers in Microbiology, 2023
Viruses are non-living organisms that rely on host cellular metabolism to complete their life cycle. Siniperca chuatsi rhabdovirus (SCRV) has caused huge economic losses to the Chinese perch (Siniperca chuatsi) industry worldwide.
Fangying Li, Fangying Li, Xiaozhe Fu, Xia Luo, Qiang Lin, Hongru Liang, Yinjie Niu, Lihui Liu, Ningqiu Li   +8 more
doaj   +1 more source

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum [PDF]

, 2015
The neuronal serpin neuroserpin undergoes polymerisation as a consequence of point mutations that alter its conformational stability, leading to a neurodegenerative dementia called familial encephalopathy with neuroserpin inclusion bodies (FENIB ...
Dalton, Lucy, Gooptu, Bibek, GUADAGNO, NOEMI ANTONELLA, Irving, James A, Lomas, David A, LUPO, GIUSEPPE, Manno, Mauro, Marciniak, Stefan J, Martorana, Vincenzo, MIRANDA BANOS, MARIA ELENA, MORICONI, CLAUDIA, Noto, Rosina, Ordoñez, Adriana, Timpano, Valentina   +13 more
core   +3 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Absorption and Screening in Phycomyces [PDF]

, 1967
In vivo absorption measurements were made through the photosensitive zones of Phycomyces sporangiophores and absorption spectra are presented for various growth media and for wavelengths between 400 and 580 mµ.
Burke, Patricia V., Delbrück, M., Zankel, K. L.   +2 more
core   +2 more sources

Deamidation at Asparagine and Glutamine As a Major Modification upon Deterioration/Aging of Proteinaceous Binders in MuralPaintings [PDF]

, 2011
Proteomic strategies are herein proved to be a complementary approach to the well established amino acid composition analysis for the characterization of the aging and deterioration phenomena occurring to proteinaceous materials in works-of-art.
A. Andreotti, BIROLO, LEILA, G. Leo, G. Marino, I. Bonaduce, M. P. Colombini, PUCCI, PIETRO   +6 more
core   +1 more source