Results 81 to 90 of about 5,196,013 (375)

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Addition of weak acids in electrolytes to prevent osmosis in aqueous organic redox flow batteries

Electrochemistry Communications, 2021
Water transfer issues related to unbalanced ionic strengths in aqueous organic redox flow batteries (AORFBs) are often overlooked. In this work, a simple strategy based on the addition of a weak acid in the negolyte was studied to prevent osmosis in ...
Jean-Marie Fontmorin, Solène Guihéneuf, Patricia Bassil, Florence Geneste, Didier Floner   +4 more
doaj  

The application of amino acid racemization in the acid soluble fraction of enamel to the estimation of the age of human teeth [PDF]

, 2008
Estimation of age-at-death for skeletonised forensic remains is one of the most significant problems in forensic anthropology. The majority of existing morphological and histological techniques are highly inaccurate, and show a bias towards ...
Collins, M. J., Griffin, R. C., Moody, H., Penkman, K. E. H.   +3 more
core   +1 more source

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd, Aljada, Andreozzi, Bauer, Boyle, Christine F. Kohlhaas, Church, Federici, Gallis, Harris, Ian P. Salt, John M. C. Connell, Kenneth Walsh, Kim, Kou, Krishna C. Yalla, Li, Li, Luo, Michell, Morrow, Mount, Potenza, Potenza, Reihill, Repetto, Salt, Steinberg, Stuart A. Ritchie, Takahashi, Tran, Ueda, Zeng   +32 more
core   +4 more sources

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

Advanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania, Manus J. P. Biggs, Katarzyna Krukiewicz   +2 more
wiley   +1 more source

A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid

Journal of the American Chemical Society, 2012
Dithiothreitol (DTT) is the standard reagent for reducing disulfide bonds between and within biological molecules. At neutral pH, however, >99% of DTT thiol groups are protonated and thus unreactive. Herein, we report on (2S)-2-amino-1,4-dimercaptobutane
John C. Lukesh, Michael J. Palte, Ronald T. Raines   +2 more
semanticscholar   +1 more source

Incorporation of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple cancer cells [PDF]

, 2012
Background: The sigma-2 receptor is an attractive target for tumor imaging and targeted therapy because it is overexpressed in multiple types of solid tumors, including prostate cancer, breast cancer, and lung cancer.
Gao, X, Gibbs, RB, Huang, Y, Li, S, Zhang, P, Zhang, Y   +5 more
core   +1 more source

Spatially Controlled 3‐D Multiplexed Aptamer Patterning in Hydrogels

Advanced Materials Interfaces, EarlyView.
A hydrogel platform based on norbornene‐functionalized polyvinyl alcohol enables high‐resolution, 3‐D multiplexed patterning of DNA aptamers via two‐photon polymerization. Two distinct aptamers are covalently immobilized with single micron‐scale precision across the x, y, and z dimensions.
Kevin Roost, Annina Stuber, Kongchang Wei, Marine de Lapeyrière, Ke Yang, Valentin Gantenbein, Salvador Pané, Ivan Corbeski, Katharina Maniura‐Weber, Nako Nakatsuka   +9 more
wiley   +1 more source

Aspartic Acid Residue 51 of SaeR Is Essential for Staphylococcus aureus Virulence

Frontiers in Microbiology, 2018
Staphylococcus aureus is a common Gram-positive bacteria that is a major cause of human morbidity and mortality. The SaeR/S two-component sensory system of S. aureus is important for virulence gene transcription and pathogenesis.
Tyler K. Nygaard, Timothy R. Borgogna, Eli W. Sward, Fermin E. Guerra, Jennifer G. Dankoff, Madison M. Collins, Kyler B. Pallister, Liang Chen, Barry N. Kreiswirth, Jovanka M. Voyich   +9 more
doaj   +1 more source