Results 21 to 30 of about 2,363,412 (175)

Potential Aspirin Resistance in Patients with Obstructive Sleep Apnea Syndrome [PDF]

, 2023
Objective:Obstructive sleep apnea syndrome (OSAS) is a common disorder among the public and it is associated with many cardio-cerebrovascular consequences.
Utku Oğan Akyıldız, Ali Akyol
core   +1 more source

Aspirin resistance [PDF]

The Lancet, 2004
Aspirin resistance is the inability of aspirin to reduce platelet production of thromboxane A2 and thereby platelet activation and aggregation. Increasing degrees of aspirin resistance may correlate independently with increasing risk of cardiovascular events.
Graeme J, Hankey, John W, Eikelboom
openaire   +5 more sources

The Incidence and Methods for Detecting Aspirin Resistance in Pediatric Patients. [PDF]

Pediatric Health Med Ther
Hansamon Poparn,1,2 Yaowaree Kittikalayawong,1,2 Piti Techavichit,1,2 Supanun Lauhasurayotin,1,2 Kanhatai Chiengthong,1,2 Phumin Chaweephisal,2 Darintr Sosothikul1,2 1Division of Pediatric Hematology and Oncology, Department of Pediatrics, Faculty of ...
Poparn H, Kittikalayawong Y, Techavichit P, Lauhasurayotin S, Chiengthong K, Chaweephisal P, Sosothikul D.   +6 more
europepmc   +2 more sources

Aspirin resistance and its importance. [PDF]

Acta medica Indonesiana, 2016
The use of salicylates (popularly known as aspirin or ASA) is well established for the secondary prevention of cardiovascular disease. However, there are reportedly a numer of patients who suffered repeat cardiovascular events despite being given aspirin “prophylaxis”, and uncertainty prevails on whether or not this is due to an inherent inability of ...
Aru W Sudoyo
openaire   +5 more sources

Aspirin resistance: position paper of the Working Group on Aspirin Resistance [PDF]

Journal of Thrombosis and Haemostasis, 2005
Aspirin irreversibly acetylates serine 529 of cyclooxygenase (COX)-1, resulting in inhibition of thromboxane A2 generation by platelets and prostacyclin by endothelial cells [1]. Because platelets lack the synthetic machinery to generate significant amounts of new COX, aspirin-induced COX-1 inhibition lasts for the lifetime of the platelet. In contrast,
MICHELSON AD, CATTANEO M, EIKELBOOM JW, GURBEL P, KOTTKE MARCHANT K, KUNICKI TJ, PULCINELLI, FABIO MARIA, CERLETTI C, RAO AK, PLATELET PHYSIOLOGY SUBCOMMITTEE OF THE SCIENTIFIC AND STANDARDIZATION COMMITTEE OF THE INTERNATIONAL SOCIETY ON THROMBOSIS AND HAEMOSTASIS, WORKING GROUP ON ASPIRIN RESISTANCE   +10 more
openaire   +5 more sources

Aspirin and Clopidogrel Resistance [PDF]

Mayo Clinic Proceedings, 2006
Despite aspirin's and clopidogrel's proven benefit in reducing cardiovascular (CV) events, recurrent CV events still occur in patients receiving antiplatelet therapy. Many of these patients are resistant or only partially responsive to the antiplatelet effects of aspirin and clopidogrel, as determined by standard platelet assays.
Erin D, Michos, Reza, Ardehali, Roger S, Blumenthal, Richard A, Lange, Hossein, Ardehali   +4 more
openaire   +2 more sources

Nasal lysine aspirin challenge in the diagnosis of aspirin - exacerbated respiratory disease [PDF]

, 2013
Background Aspirin-exacerbated respiratory disease is under-diagnosed and therefore effective and inexpensive therapy with aspirin desensitization is rarely performed.
J. Larco, R. Mirakian, G. Scadding, Miller, B, Darby, Y, Larco, J, Sannah, AA, Scadding, G, Mirakian, R, Y. Darby, Gane, S, B. Miller, S. Gane, A. A. Sannah   +13 more
core   +1 more source

Drug resistance with monitored adherence [PDF]

, 2013
Drug resistance can be defined as the failure of a drug to exert its expected effect on pharmacological biomarkers and is caused by pharmacogenetic, cellular or clinical factors.
Walter, Philipp Niklaus
core   +1 more source

Aspirin “Resistance”

Herz Kardiovaskuläre Erkrankungen, 2008
Recent clinical studies have shown that the expected antiplatelet effect of aspirin is not always achieved. From the laboratory point of view, resistance to aspirin is the inability to achieve the expected inhibition of platelet cyclooxygenase-(COX-)1 with prevention of platelet thromboxane (TX) A2 formation.
Norbert, Zimmermann, Artur-Aron, Weber, Thomas, Hohlfeld   +2 more
  +7 more sources

Mechanistic view into the therapeutic effect, anticancer potential and the adverse effect of aspirin [PDF]

MATEC Web of Conferences
In this research, the working mechanism behind the therapeutic effect of aspirin will be discussed in detail. Aspirin will also be assessed as a promising drug to treat cancerous cells in the future.
Ouyang Juan
doaj   +1 more source