Results 21 to 30 of about 88,633 (281)

Aspirin resistance: position paper of the Working Group on Aspirin Resistance [PDF]

Journal of Thrombosis and Haemostasis, 2005
Aspirin irreversibly acetylates serine 529 of cyclooxygenase (COX)-1, resulting in inhibition of thromboxane A2 generation by platelets and prostacyclin by endothelial cells [1]. Because platelets lack the synthetic machinery to generate significant amounts of new COX, aspirin-induced COX-1 inhibition lasts for the lifetime of the platelet. In contrast,
MICHELSON AD, CATTANEO M, EIKELBOOM JW, GURBEL P, KOTTKE MARCHANT K, KUNICKI TJ, PULCINELLI, FABIO MARIA, CERLETTI C, RAO AK, PLATELET PHYSIOLOGY SUBCOMMITTEE OF THE SCIENTIFIC AND STANDARDIZATION COMMITTEE OF THE INTERNATIONAL SOCIETY ON THROMBOSIS AND HAEMOSTASIS, WORKING GROUP ON ASPIRIN RESISTANCE   +10 more
openaire   +5 more sources

Novel applications of COX-2 inhibitors, metformin, and statins for the primary chemoprevention of breast cancer [PDF]

, 2016
Recent evidence shows that commonly prescribed drugs, such as non-steroidal anti-inflammatory drugs (NSAIDs), metformin, and statins, may have beneficial roles in the primary chemoprevention of breast cancer.
Micallef, Darren, Micallef, Sarah, Schembri-Wismayer, Pierre, Calleja-Agius, Jean   +3 more
core   +2 more sources

TRUE RESISTANCE AND PSEUDORESISTANCE TO ASPIRIN

Рациональная фармакотерапия в кардиологии, 2015
Low dose aspirin reduces the secondary incidence of myocardial infarction and stroke. Drug resistance to aspirin might result in treatment failure.
A. I. Martynov, E. V. Akatova, I. V. Urlayeva, O. P. Nicolin   +3 more
doaj   +3 more sources

Decreased turnover aspirin resistance by bidaily aspirin intake and efficient cytoreduction in myeloproliferative neoplasms

Platelets, 2018
Essential thrombocythemia (ET) and polycythemia vera (PV) are myeloproliferative neoplasms (MPN) with an increased risk of arterial and venous thrombosis.
Andréas Perrier-Cornet, Jean-Christophe Ianotto, Fanny Mingant, Maëla Perrot, Eric Lippert, Hubert Galinat   +5 more
doaj   +1 more source

Mechanistic view into the therapeutic effect, anticancer potential and the adverse effect of aspirin [PDF]

MATEC Web of Conferences
In this research, the working mechanism behind the therapeutic effect of aspirin will be discussed in detail. Aspirin will also be assessed as a promising drug to treat cancerous cells in the future.
Ouyang Juan
doaj   +1 more source

Прогностическое значение аспиринорезистентности при ишемической болезни сердца [PDF]

, 2008
Рассмотрены данные литературы о значении аспиринорезистентности при ИБС. Предложен разработанный авторами новый экспресс−метод определения чувствительности к аспирину.
Adolescent development: Characteristics and determinants, De Bree, Elise, Donker, Monika, Education and Learning: Cognitive and Motor Disabilities, Education and Learning: Development in Interaction, Kroesbergen, Evelyn, Leerstoel Leseman, Leerstoel Luit, Leerstoel van Gog, Leerstoel van Tartwijk, Slot, Esther, Van Viersen, Sietske   +11 more
core   +3 more sources

Is clopidogrel better than aspirin following breakthrough strokes while on aspirin? A retrospective cohort study. [PDF]

, 2014
ObjectiveThere is insufficient evidence on which to base a recommendation for optimal antiplatelet therapy following a stroke while on aspirin. The objective was to compare clopidogrel initiation vs aspirin reinitiation for vascular risk reduction among ...
Chang, Ku-Chou, Lee, Hsuei-Chen, Lee, Jiann-Der, Lee, Meng, Lee, Tsong-Hai, Ovbiagele, Bruce, Rao, Neal M, Saver, Jeffrey L, Wang, Hui-Hsuan, Wu, Chih-Ying, Wu, Yi-Ling   +10 more
core   +1 more source

'Aspirin resistance' or treatment non-compliance: Which is to blame for cardiovascular complications?

Journal of Translational Medicine, 2008
Aspirin is one of the 'cornerstone' drugs in our current management of cardiovascular disorders. However, despite the prescription of aspirin recurrent vascular events still occur in 10–20% of patients.
Shantsila Eduard, Lip Gregory YH
doaj   +1 more source

Aspirin resistance: causes, clinical significance, correction

Mìžnarodnij Endokrinologìčnij Žurnal, 2022
Aspirin is the most frequently prescribed antiplatelet agent today. It exerts its antiplatelet effect by irreversible inactivation of the platelet cyclooxygenase-1, resulting in an irreversible inhibition of thromboxane-A2 formation. The clinical benefit
G.F. Gendeleka, A.N. Gendeleka
doaj   +1 more source

Aspirin resistance and ischemic heart disease on Iranian experience

Advanced Biomedical Research, 2012
Background: Coronary artery disease (CAD) and myocardial infarction are the most common causes of mortality and morbidity all over the world.
Masoumeh Sadeghi, Afsoon Emami, Naghmeh Ziyaei, Majid Yaran, Allahyar Golabchi, Azam Sadeghi   +5 more
doaj   +1 more source