Results 111 to 120 of about 5,490,229 (291)

Discovering gene association networks by multi-objective evolutionary quantitative association rules

Journal of Computer and System Sciences, 2014
Junta de Andalucía P11-TIC ...
María Martínez-Ballesteros, Isabel A. Nepomuceno-Chamorro, José C. Riquelme   +2 more
openaire   +5 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Emergent associative memory as a local organising principle for global adaptation in adaptive networks

, 2011
Complex adaptive systems composed of self-interested agents can in some circumstances self-organise into structures that enhance global adaptation or efficiency. However, the general conditions for such an outcome are poorly understood.
Buckley, Christopher L., Mills, Rob, Watson, Richard A.   +2 more
core   +1 more source

Modelling gene regulatory networks: systems biology to complex systems

Draft literature review on approaches to modelling gene regulatory ...
Geard, Nicholas
core   +1 more source

In silico reconstruction of the gene network for cytokine regulation of ASD-associated

Vavilov Journal of Genetics and Breeding
   Accumulated evidence links dysregulated cytokine signaling to the pathogenesis of autism spectrum disorder (ASD), implicating genes, proteins, and their intermolecular networks. This paper systematizes these findings using bioinformatics analysis and machine learning methods.    The primary tool employed in the
N. M. Levanova, E. G. Vergunov, A. N. Savostyanov, I. V. Yatsyk, V. A. Ivanisenko   +4 more
openaire   +3 more sources

Identifying prognosis and metastasis‑associated genes associated with Ewing sarcoma by weighted gene co‑expression network analysis

Oncology Letters, 2019
Ewing sarcoma (ES) is a highly malignant pediatric tumor with a low survival rate and a high rate of metastasis. However, there have been limited reports on the exploration of new biomarkers of ES. Therefore, the aim of the present study was to identify the potential hub genes associated with overall vital survival (OVS) and metastasis in ES ...
Wang, Ben, Li, Jie, Li, Xin, Ou, Yunsheng   +3 more
openaire   +3 more sources

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Evolution under fluctuating environments explains observed robustness in metabolic networks [PDF]

, 2010
Copyright: © 2010 Soyer, Pfeiffer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Pfeiffer, Thomas, Thomas Pfeiffer, Orkun S. Soyer, Soyer Orkun S., Orkun S Soyer, Soyer, Orkun S., Pfeiffer Thomas   +6 more
core   +1 more source

Functional network analysis of gene-phenotype connectivity associated with temozolomide

Oncotarget, 2017
Glioma has a poor survival rate in patients even with aggressive treatment. Temozolomide (TMZ) is the standard chemotherapeutic choice for treating glioma, but TMZ treatment consistently leads to high resistance.To investigate the underlying mechanisms of TMZ action with new therapeutic regimens in glioma.The biological effects of TMZ mainly depend on ...
Shi, Jia, Dong, Bo, Zhou, Peng, Guan, Wei, Peng, Ya   +4 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source