Results 101 to 110 of about 5,490,229 (291)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Life-Long Learning and Evolving Associative Memories in Brain-Inspired Spiking Neural Networks [PDF]

The paper argues that evolving associative memories (EAM), that are manifested in all biological systems and realised in the human brain through life-long learning (LLL), can be realised in brain-inspired computational architectures based on spiking ...
K Kasabov, Nikola
core   +1 more source

Model tree to improve the inference of gene association networks

AI Communications, 2016
We propose a novel methodology to infer gene association networks from gene expression profiles (microarray data) based on the application of model tree. We first build a regression tree for each gene and second, we build a graph from all the linear relationships among output and input genes taking into account whether the pair of genes is ...
openaire   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Integrated analysis of phenotypes and whole-transcriptome data for the preliminary exploration of molecular regulatory networks influencing beef quality

Food Chemistry: Molecular Sciences
Guyuan cattle are a unique indigenous genetic resource in Northwest China, characterized by favorable roughage utilization efficiency and meat production potential.
Mengli Yang, Xue Bai, Yuan Liu, Hongen Chu, Bei Cai, Runjun Yang, Lupei Zhang, Fen Li, Yun Ma   +8 more
doaj   +1 more source

Structural and Functional Insights into WRKY3 and WRKY4 Transcription Factors to Unravel the WRKY–DNA (W-Box) Complex Interaction in Tomato (Solanum lycopersicum L.). A Computational Approach

Frontiers in Plant Science, 2017
The WRKY transcription factors (TFs), play crucial role in plant defense response against various abiotic and biotic stresses. The role of WRKY3 and WRKY4 genes in plant defense response against necrotrophic pathogens is well-reported.
Mohd Aamir, Vinay K. Singh, Mukesh Meena, Ram S. Upadhyay, Vijai K. Gupta, Surendra Singh   +5 more
doaj   +1 more source

A Network and Pathway Analysis of Genes Associated With Atrial Fibrillation

Cardiovascular Therapeutics
Background: Atrial fibrillation (AF) is affected by both environmental and genetic factors. Previous genetic association studies, especially genome‐wide association studies, revealed a large group of AF‐associated genes. However, little is known about the functions and interactions of these genes. Moreover, established genetic variants of AF contribute
Mengying Zeng, Xian Yang, Yunhao Chen, Jinqi Fan, Li Cao, Menghao Wang, Peilin Xiao, Zhiyu Ling, Yuehui Yin, Yunlin Chen   +9 more
openaire   +3 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Enhanced cerebral blood flow similarity of the somatomotor network in chronic insomnia: Transcriptomic decoding, gut microbial signatures and phenotypic roles

NeuroImage
Chronic insomnia (CI) is a complex disease involving multiple factors including genetics, gut microbiota, and brain structure and function. However, there lacks a unified framework to elucidate how these factors interact in CI.
Xiaofen Ma, Junle Li, Yuping Yang, Xiaofan Qiu, Jintao Sheng, Ningke Han, Changwen Wu, Guang Xu, Guihua Jiang, Junzhang Tian, Xuchu Weng, Jinhui Wang   +11 more
doaj   +1 more source