Results 81 to 90 of about 5,490,229 (291)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

PRINCIPLE: a tool for associating genes with diseases via network propagation [PDF]

Bioinformatics, 2011
Abstract Summary: PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein–protein interaction network to genes causing phenotypically similar disorders to the query disease.
Assaf Gottlieb, Oded Magger, Igor Berman, Eytan Ruppin, Roded Sharan   +4 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Document Categorization using Multilingual Associative Networks based on Wikipedia [PDF]

, 2015
Associative networks are a connectionist language model with the ability to categorize large sets of documents. In this research we combine monolingual associative networks based on Wikipedia to create a larger, multilingual associative network, using ...
Theune, Mariet; id_orcid, de Jong, Franciska M.G., Mariët Theune, Bloom, Niels, Niels Bloom, Franciska De Jong   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

“Guilt by Association” Is the Exception Rather Than the Rule in Gene Networks

PLoS Computational Biology, 2012
Gene networks are commonly interpreted as encoding functional information in their connections. An extensively validated principle called guilt by association states that genes which are associated or interacting are more likely to share function. Guilt by association provides the central top-down principle for analyzing gene networks in functional ...
Jesse A. Gillis, Paul Pavlidis
openaire   +5 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Nonparametric Bayesian inference for perturbed and orthologous gene regulatory networks [PDF]

, 2012
Motivation: The generation of time series transcriptomic datasets collected under multiple experimental conditions has proven to be a powerful approach for disentangling complex biological processes, allowing for the reverse engineering of gene ...
Penfold, Christopher A., Buchanan-Wollaston, Vicky, Wild, David L., Denby, Katherine J.   +3 more
core   +1 more source

Molecular-genetic mechanisms of the interaction between processes of cell response to mechanical stress and neuronal apoptosis in primary open-angle glaucoma

Вавиловский журнал генетики и селекции, 2017
Glaucoma is a chronic and progressive disease, which affects more than 60 million people worldwide. Primary open-angle glaucoma (POAG) is one of the most common forms of glaucoma.
O. V. Saik, N. A. Konovalova, P. S. Demenkov, N. V. Ivanisenko, T. V. Ivanisenko, D. E. Ivanoshchuk, O. S. Konovalova, O. A. Podkolodnaya, I. N. Lavrik, N. A. Kolchanov, V. A. Ivanisenko   +10 more
doaj   +1 more source