Results 61 to 70 of about 5,490,229 (291)

Exploring gene-disease associations by gene network analysis on PubMed

, 2022
Assembling valid and thorough information on genes and their relation in different disease entities is a challenging task. For example, searching for a gene like “TP53” in PubMed returns around 25,000 results. To extract the information of interest, tedious manual screening would be necessary. To overcome these limitations, we developed
Beslendi, Can, Fujarski, Michael, Sandmann, Sarah, Varghese, Julian   +3 more
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Reservoir computing with output feedback [PDF]

, 2011
Reinhart RF. Reservoir computing with output feedback. Bielefeld: Bielefeld University; 2011.A dynamical system approach to forward and inverse modeling is proposed. Forward and inverse models are trained in associative recurrent neural networks that are
Reinhart, René Felix, Reinhart, Felix
core   +1 more source

Predicting response to preoperative chemotherapy agents by identifying drug action on modeled microRNA regulation networks. [PDF]

PLoS ONE, 2014
Identifying patients most responsive to specific chemotherapy agents in neoadjuvant settings can help to maximize the benefits of treatment and minimize unnecessary side effects.
Lida Zhu, Juan Liu, Fengji Liang, Simon Rayner, Jianghui Xiong   +4 more
doaj   +1 more source

Cell Cycle Gene Networks Are Associated with Melanoma Prognosis

PLoS ONE, 2012
Our understanding of the molecular pathways that underlie melanoma remains incomplete. Although several published microarray studies of clinical melanomas have provided valuable information, we found only limited concordance between these studies. Therefore, we took an in vitro functional genomics approach to understand melanoma molecular pathways ...
Wang, L, Hurley, DG, Watkins, W, Araki, H, Tamada, Y, Muthukaruppan, A, Ranjard, L, Derkac, E, Imoto, S, Miyano, S, Crampin, EJ, Print, CG   +11 more
openaire   +4 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Global exponential periodicity of a class of bidirectional associative memory networks with finite distributed delays

, 2005
In this paper, we study the periodic oscillatory behavior of a class of bidirectional associative memory (BAM) networks with finite distributed delays.
Li, C., Yang, X., Megson, G.M., Evans, D.J., Liao, X., Li, C. D., Megson, G. M., Yang, X. F., Liao, X. F., Evans, D. J.   +9 more
core   +1 more source

Individual and global adaptation in networks

, 2012
The structure of complex biological and socio-economic networks affects the selective pressures or behavioural incentives of components in that network, and reflexively, the evolution/behaviour of individuals in those networks changes the structure of ...
Watson, Richard
core   +1 more source

Identification of Candidate Genes and Gene Networks Specifically Associated with Analgesic Tolerance to Morphine [PDF]

The Journal of Neuroscience, 2009
Chronic morphine administration may alter the expression of hundreds to thousands of genes. However, only a subset of these genes is likely involved in analgesic tolerance. In this report, we used a behavior genetics strategy to identify candidate genes specifically linked to the development of morphine tolerance.
Jenica D, Tapocik, Noah, Letwin, Cheryl L, Mayo, Bryan, Frank, Troung, Luu, Ovokeraye, Achinike, Carrie, House, Russell, Williams, Greg I, Elmer, Norman H, Lee   +9 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source