Results 121 to 130 of about 283,599 (345)
Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins [PDF]
, 2022 Chigure Suzuki +7 more
openalex +1 more source
Astragaloside IV inhibits astrocyte senescence: implication in Parkinson’s disease
Journal of Neuroinflammation, 2020 Senescent astrocytes have been implicated in the aging brain and neurodegenerative disorders, including Parkinson’s disease (PD). Astragaloside IV (AS-IV) is an antioxidant derivative from a traditional Chinese herbal medicine Astragalus membraneaceus ...
Mei-Ling Xia +4 more
semanticscholar +1 more source
Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex
Advanced Healthcare Materials, EarlyView.Delivering light deep into the brain over a large volume while causing minimal tissue damage is a major challenge for non‐human primate optogenetics. This study evaluates Utah Optrode Array designs in vivo, revealing how changes in shank geometry, surface texture, and insertion parameters minimize acute damage—offering a path toward high‐precision ...
Adrián Villamarin‐Ortiz +8 more
wiley +1 more source
Astrocyte dynamics revisited [PDF]
A vast amount of experimental evidence hints that astrocytes could be active players in information processing of the brain. It remains unclear nevertheless how these cells could encode synaptic stimuli through variations of their intracellular Ca2 ...
DE PITTA', MAURIZIO
core
Advanced Healthcare Materials, EarlyView.An advanced on‐chip cortical network platform merges human stem cell‐derived neurons with microfabricated devices, enabling precise large‐format circuit design, optogenetic control, and molecular dissection of synaptic formation. This innovative system offers a powerful new tool to explore and model brain connectivity, disease mechanisms, can serve as ...
Pacharaporn Suklai +9 more
wiley +1 more source
The Energy Status of Astrocytes Is the Achilles’ Heel of eIF2B-Leukodystrophy [PDF]
, 2021 Melisa Herrero +3 more
openalex +1 more source
International Journal of Molecular Sciences, 2019 The blood-brain barrier (BBB) is a major functional barrier in the central nervous system (CNS), and inhibits the extravasation of intravascular contents and transports various essential nutrients between the blood and the brain.
S. Michinaga, Y. Koyama
semanticscholar +1 more source
A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds
Advanced Healthcare Materials, EarlyView.Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico +8 more
wiley +1 more source
Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders
Nature Reviews Neuroscience, 2022 Ashley N. Brandebura +3 more
semanticscholar +1 more source