Results 61 to 70 of about 283,599 (345)

Sustained synchronized neuronal network activity in a human astrocyte co-culture system [PDF]

, 2016
Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative disorders such as autism, schizophrenia, and Alzheimer's disease and is typically studied using genetically modified cellular and animal models.
Brône, Bert, Cik, Miroslav, De Vos, Winnok, Detrez, Jan R, Diels, Annick, Kuijlaars, Jacobine, Meert, Theo, Meneghello, Giulia, Nuydens, Rony, Oyelami, Tutu, Peeters, Pieter J, Rohrbacher, Jutta, Tuefferd, Marianne, Verheyen, An, Verschuuren, Marlies, Verstraelen, Peter, Versweyveld, Sofie   +16 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Calcium imaging and BAPTA loading of amygdala astrocytes in mouse brain slices

STAR Protocols, 2022
Summary: Astrocytes are glial cells that exhibit calcium signaling-mediated activity. Here, we present a protocol to monitor and manipulate astrocyte calcium activity from mouse amygdala slices.
Angel Baudon, Etienne Clauss-Creusot, Pascal Darbon, Ryan Patwell, Valery Grinevich, Alexandre Charlet   +5 more
doaj   +1 more source

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e Mediates Aglycemic Neuronal Cell Death [PDF]

, 2015
The astrocyte cystine/glutamate antiporter (system xc−) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred.
He, Yan, Hewett, James A., Hewett, Sandra J., Jackman, Nicole A., Lobner, Doug, Thorn, Trista L.   +5 more
core   +1 more source

The preventive and treatment effect of Urtica dioica on astrocyte density in the CA1 and CA3 subfields of hippocampus in STZ induced diabetic rats [PDF]

, 2013
Several animal model studies have shown that Diabetes mellitus can affect on the activity of hippocampus astrocytes, but these studies reported controversial findings.
Afshar, M., Ghafari, S., Golalipour, M.J., Jahanshahi, M.   +3 more
core   +1 more source

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor

Nature Network Boston, 2016
Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional response to type I interferons (IFN-Is) in astrocytes during experimental CNS autoimmunity and also ...
Veit Rothhammer, I. Mascanfroni, L. Bunse, M. Takenaka, Jessica E. Kenison, L. Mayo, C. Chao, B. Patel, Raymond Yan, M. Blain, Jorge I Alvarez, Hania Kebir, N. Anandasabapathy, G. Izquierdo, Steffen Jung, N. Obholzer, N. Pochet, C. Clish, M. Prinz, A. Prat, J. Antel, F. Quintana   +21 more
semanticscholar   +1 more source

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The accumulation of amyloid β (Aβ) in the brain appears to be a necessary event in the pathogenesis of Alzheimer’s disease (AD). However, processes linked to the endogenous regulation of Aβ production are still not completely understood ...
Hao Wang, Joshua A. Kulas, Chao Wang, D. Holtzman, H. Ferris, S. Hansen   +5 more
semanticscholar   +1 more source

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source

Extracellular regulated kinase 1/2 signaling is a critical regulator of interleukin-1β-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression.

PLoS ONE, 2013
Astrocytes are essential for proper central nervous system (CNS) function and are intricately involved in neuroinflammation. Despite evidence that immune-activated astrocytes contribute to many CNS pathologies, little is known about the inflammatory ...
Jerel Fields, Irma E Cisneros, Kathleen Borgmann, Anuja Ghorpade   +3 more
doaj   +1 more source

Enduring alterations in hippocampal astrocytesynaptic proximity following adolescent alcohol exposure: reversal by gabapentin

Neural Regeneration Research, 2020
Adolescent alcohol abuse is a substantive public health problem that has been the subject of intensive study in recent years. Despite reports of a wide range of effects of adolescent intermittent ethanol (AIE) exposure on brain and behavior, little is ...
Kati L Healey, Sandra Kibble, Sierra Hodges, Kathryn J Reissner, Anze Testen, Tiffany A Wills, Shawn K Acheson, Benjamin M Siemsen, John A McFaddin, Michael D Scofield, H Scott Swartzwelder   +10 more
doaj   +1 more source