Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1
eLife, 2019 Brain-derived neurotrophic factor (BDNF) is a critical growth factor involved in the maturation of the CNS, including neuronal morphology and synapse refinement.
Leanne M Holt +5 more
doaj +1 more source
Versatile and simple approach to determine astrocyte territories in mouse neocortex and hippocampus. [PDF]
PLoS ONE, 2013 BACKGROUND: Besides their neuronal support functions, astrocytes are active partners in neuronal information processing. The typical territorial structure of astrocytes (the volume of neuropil occupied by a single astrocyte) is pivotal for many aspects ...
Antje Grosche +13 more
doaj +1 more source
The role of reactive astrocitose in the chronological evolution of traumatic brain injury [PDF]
, 2018 Introduction and objectives. This study aims to investigate whether the cerebral modifications of posttraumatic reactive astrocitose can be considered an objective criterion for determining the age of traumatic cranio-cerebral lesions.
Belis, Vladimir +5 more
core +4 more sources
Scientific Reports, 2021 Astrocyte glycogen, the primary energy reserve in brain, undergoes continuous remodeling by glucose passage through the glycogen shunt prior to conversion to the oxidizable energy fuel l-lactate.
Khaggeswar Bheemanapally +3 more
doaj +1 more source
Astrocytic gliotransmission as a pathway for stable stimulation of post-synaptic spiking: Implications for working memory [PDF]
arXiv, 2023 The brain consists not only of neurons but also of non-neuronal cells, including astrocytes. Recent discoveries in neuroscience suggest that astrocytes directly regulate neuronal activity by releasing gliotransmitters such as glutamate. In this paper, we consider a biologically plausible mathematical model of a tripartite neuron-astrocyte network.
arxiv
Astrocyte-induced positive integrated information in neuroglial ensembles [PDF]
Phys. Rev. E 99, 012418 (2019), 2018 The Integrated Information is a quantitative measure from information theory how tightly all parts of a system are interconnected in terms of information exchange. In this study we show that astrocyte, playing an important role in regulation of information transmission between neurons, may contribute to a generation of positive Integrated Information ...
arxiv +1 more source
Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. [PDF]
, 2017 Prions are infectious agents that cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD). The absence of a human cell culture model that replicates human prions has hampered prion disease research for decades.
Alibhai, James +9 more
core +1 more source
Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow. [PDF]
, 2017 The unique properties of brain capillary endothelium, critical in maintaining the blood-brain barrier (BBB) and restricting water permeability across the BBB, have important consequences on fluid hydrodynamics inside the BBB hereto inadequately ...
Igarashi, Hironaka +3 more
core +1 more source
A spatial threshold for astrocyte calcium surge
eLifeAstrocytes are active cells involved in brain function through the bidirectional communication with neurons, in which astrocyte calcium plays a crucial role.
Justin Lines +7 more
doaj +1 more source
Neural Regeneration Research, 2020 Adolescent alcohol abuse is a substantive public health problem that has been the subject of intensive study in recent years. Despite reports of a wide range of effects of adolescent intermittent ethanol (AIE) exposure on brain and behavior, little is ...
Kati L Healey +10 more
doaj +1 more source