Results 81 to 90 of about 194,703 (370)
Neuron-Astrocyte Interactions in Parkinson’s Disease
Cells, 2020 Parkinson’s disease (PD) is the second most common neurodegenerative disease. PD patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural instability due to a loss of nigrostriatal dopaminergic neurons.
I. Miyazaki, M. Asanuma
semanticscholar +1 more source
Trends in Cell BiologyAstrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, and star-like. A central precept of this review is that such complex morphological shapes evolved to allow astrocytes to contact and signal with diverse ...
Baldwin, Katherine T +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity
Cells, 2023 Structural changes of astrocytes and their perisynaptic processes occur in response to various physiological and pathophysiological stimuli. They are thought to profoundly affect synaptic signalling and neuron-astrocyte communication.
Cátia Domingos +8 more
doaj +1 more source
Astrocytes as a mechanism for meta-plasticity and contextually-guided network function [PDF]
arXiv, 2023 Astrocytes are a ubiquitous and enigmatic type of non-neuronal cell and are found in the brain of all vertebrates. While traditionally viewed as being supportive of neurons, it is increasingly recognized that astrocytes may play a more direct and active role in brain function and neural computation.
arxiv
Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits
Nature Neuroscience, 2020 How astrocytes grow and integrate into neural circuits remains poorly defined. Zebrafish are well suited for such investigations, but bona fide astrocytes have not been described in this system.
Jiakun Chen +3 more
semanticscholar +1 more source
The Role of Astrocytes in Remyelination [PDF]
Trends in Neurosciences, 2020 Remyelination is the regeneration of myelin sheaths following demyelination. This regenerative process is critical for the re-establishment of axonal conduction velocity and metabolic support to the axons. Successful remyelination in the CNS generally depends on the activation, proliferation, and differentiation of oligodendrocyte progenitor cells ...
Rawji, Khalil S +3 more
openaire +4 more sources
Astrocyte remodeling without gliosis precedes optic nerve axonopathy
Acta Neuropathologica Communications, 2018 Astroyctes serve myriad functions but are especially critical in white matter tracts, where energy-demanding axons propagate action potentials great distances between neurons.
Melissa L. Cooper +2 more
doaj +1 more source
Astrocytic control in in vitro and simulated neuron-astrocyte networks
Proceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication, 2021 Astrocytes are involved in the information propagation in the brain by interacting with neurons. Computational modeling helps to study the underlying mechanisms for this communication deeply. In this work, we aimed to analyze how the number of astrocytes and the resulting astrocytic network structure affects neuronal activity.
Genocchi, Barbara +5 more
openaire +3 more sources
ASN Neuro, 2020 Norepinephrine (NE) control of hypothalamic gluco-regulation involves astrocyte-derived energy fuel supply. In male rats, exogenous NE regulates astrocyte glycogen metabolic enzyme expression in vivo through 5’-AMP-activated protein kinase (AMPK ...
Mostafa M. H. Ibrahim +3 more
doaj +1 more source