Results 91 to 100 of about 31,071 (248)

Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine

Cell Reports, 2019
Summary: In addition to their support role in neurotransmitter and ion buffering, astrocytes directly regulate neurotransmission at synapses via local bidirectional signaling with neurons.
Chun Chen, ZhiYing Jiang, Xin Fu, Diankun Yu, Hai Huang, Jeffrey G. Tasker   +5 more
doaj   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Role of astrocytes in the pathogenesis of perinatal brain injury

Molecular Medicine
Astrocytes, the most abundant glial cells in the central nervous system (CNS), play critical roles in blood–brain barrier (BBB) maintenance, synaptogenesis, neurotransmission, and metabolic regulation.
Ling Li, Xuewei Cui, Baoli Zhu, Lele Zhou, Yaya Guo, Tianjing Liu, Yongyan Shi   +6 more
doaj   +1 more source

Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory

Nature Communications, 2019
How astrocytes influence neuronal plasticity remains unclear, as they are typically considered as modulators of core mechanisms driven by neuronal components.
Marta Navarrete, María I. Cuartero, Rocío Palenzuela, Jonathan E. Draffin, Ainoa Konomi, Irene Serra, Sandra Colié, Sergio Castaño-Castaño, Mazahir T. Hasan, Ángel R. Nebreda, José A. Esteban   +10 more
doaj   +1 more source

Channel capacity of calcium signalling based on inter-cellular calcium waves in astrocytes

2013 IEEE International Conference on Communications Workshops (ICC), 2013
In this paper we investigate the channel capacity of the calcium signalling system based on an inter-cellular calcium wave model for astrocytes in the literature. Calcium signalling is a good candidate for molecular communication due to its long communication range, possible usage of existing cellular infrastructure, and its minimally invasive nature ...
Akif Cem Heren, Mehmet Sükrü Kuran, H. Birkan Yilmaz, Tuna Tugcu   +3 more
openaire   +2 more sources

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Characterization of the Astrocyte Calcium Response to Norepinephrine in the Ventral Tegmental Area

Cells
Astrocytes from different brain regions respond with Ca2+ elevations to the catecholamine norepinephrine (NE). However, whether this noradrenergic-mediated signaling is present in astrocytes from the ventral tegmental area (VTA), a dopaminergic circuit ...
Michele Speggiorin, Angela Chiavegato, Micaela Zonta, Marta Gómez-Gonzalo   +3 more
doaj   +1 more source

Prostanoid Receptor-Mediated Calcium Signaling in Cultured Rat Astrocytes

Japanese Journal of Pharmacology, 1996
We investigated prostanoid-induced intracellular Ca2+ mobilization in Ca(2+)-sensitive dye fura-2-loaded cultured astrocytes. The thromboxane (TX) A2 analog STA2 (9,11-epithio-11,12-methano-TXA2) and/or prostaglandin (PG) F2 alpha (each used at 1 microM) stimulated intracellular Ca2+ mobilization in single cultured rat type 1 astrocytes. Three response
Kitanaka, Junichi, Takuma, Kazuhiro, Kondo, Kaoru, Baba, Akemichi   +3 more
openaire   +3 more sources

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source