Results 181 to 190 of about 31,071 (248)

Scn1a‐mediated developmental regulation of prefrontal cortex plasticity and cognition

Epilepsia, EarlyView.
Abstract Objective The voltage‐gated sodium channel Nav1.1, encoded by Scn1a, is essential for γ‐aminobutyric acid (GABA)ergic function, and its alteration is associated with neurological disorders such as Dravet syndrome and Alzheimer's disease. We previously demonstrated that local Nav1.1 dysfunction in the medial prefrontal cortex (mPFC) during ...
Maurizio S. Riga, Mercedes Pérez‐Fernández, Yuniesky Andrade‐Talavera, Benito Domínguez‐Velasco, Antonio Rodríguez‐Moreno, Manuel Álvarez‐Dolado   +5 more
wiley   +1 more source

The functional role of astrocyte calcium signaling in cortical blood flow regulation. [PDF]

J Neurosci, 2015
Biesecker KR, Srienc AI.
europepmc   +1 more source

Transcriptomic analysis reveals distinct expression patterns in focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a common cause of drug‐resistant epilepsy in children and adults and exhibits substantial clinical and histopathological heterogeneity. However, morphological classification alone does not fully explain variability in epileptogenicity, disease severity, or treatment response.
Shivani Sonawane, Michal Hendrych, Michaela Ručková, Robin Jugas, Jan Vrbský, Martin Pail, Barbora Straka, Martina Strnadová, Lenka Krsková, Adam Vácha, Miroslav Koblížek, Barbora Splítková, Kateřina Koželková, Eliška Hloušková, Tereza Vaňková, Josef Zámečník, Štefánia Aulická, Markéta Hermanová, Pavel Kršek, Ondřej Slabý, Milan Brázdil   +20 more
wiley   +1 more source

Glial syncytial control fields and the low-frequency resonome of the human brain. [PDF]

Front Hum Neurosci
Ballús Santacana A.
europepmc   +1 more source

Human induced pluripotent stem cell‐derived cortical neurons from monozygotic twins with the Gαo1K278del mutation reveal disease mechanisms relevant to GNAO1‐related encephalopathy

Epilepsia, EarlyView.
Abstract Objective Rare de novo variants in GNAO1 cause a severe neurodevelopmental disorder characterized by a heterogenous display of early onset epilepsy, movement abnormalities, and global developmental delay. More than 100 pathogenic variants in GNAO1 have been identified and categorized into four groups according to their protein features.
Maria Sáez González, Kes Kloosterhuis, Jeroen Vreijling, Hailiang Mei, Tom P. Hellings, Davide Pirolli, Anine H. Stam, Arn M. J. M. van den Maagdenberg, Vivi M. Heine, Jean‐Philippe Frimat, Laura A. van de Pol, Frank Baas, Harald M. M. Mikkers   +12 more
wiley   +1 more source

Astrocytes improve tactile categorization by modulating sensory processing in neurons. [PDF]

iScience
Calero-Vargas A, Higinio-Rodríguez F, Olivares-Moreno R, Rodríguez-Blanco LA, de Lafuente V, Gutierrez R, Rojas-Piloni G, Pérez O, López-Hidalgo M.   +8 more
europepmc   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

The 3-Body Problem: How Astrocytes May Govern Plasticity. [PDF]

Neuroscientist
Watanabe A, Guo C, Sjöström PJ.
europepmc   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source