Results 51 to 60 of about 303,608 (351)

Crosstalk Between Astrocytes and Microglia: An Overview

Frontiers in Immunology, 2020
Based on discoveries enabled by new technologies and analysis using novel computational tools, neuroscience can be re-conceived in terms of information exchange in dense networks of intercellular connections rather than in the context of individual ...
A. Matejuk, R. Ransohoff
semanticscholar   +1 more source

Gene expression profiles of reactive astrocytes cultured from dopamine-depleted striatum

Neurobiology of Disease, 2005
We have carried out cDNA array analysis in order to characterize the gene expression profiles of reactive astrocytes from dopamine-depleted striatum.
Takao Nakagawa, Takeshi Yabe, Joan P. Schwartz   +2 more
doaj   +1 more source

Alterations of gene expression and glutamate clearance in astrocytes derived from an MeCP2-null mouse model of Rett syndrome. [PDF]

PLoS ONE, 2012
Rett syndrome (RTT) is a neurodevelopmetal disorder associated with mutations in the methyl-CpG-binding protein 2 (MeCP2) gene. MeCP2-deficient mice recapitulate the neurological degeneration observed in RTT patients.
Yasunori Okabe, Tomoyuki Takahashi, Chiaki Mitsumasu, Ken-ichiro Kosai, Eiichiro Tanaka, Toyojiro Matsuishi   +5 more
doaj   +1 more source

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

Acta Neuropathologica Communications, 2021
Alzheimer’s disease (AD) is the most common cause of age-related dementia. Increasing evidence suggests that neuroinflammation mediated by microglia and astrocytes contributes to disease progression and severity in AD and other neurodegenerative ...
Jong-sung Park, T. Kam, Saebom Lee, Hyejin Park, Yumin Oh, Seung-Hwan Kwon, Jae-Jin Song, Donghoon Kim, Hyunhee Kim, Aanishaa Jhaldiyal, D. Na, Kang-Choon Lee, Eun Ji Park, M. Pomper, O. Pletnikova, J. Troncoso, H. Ko, V. Dawson, T. Dawson, Seulki Lee   +19 more
semanticscholar   +1 more source

Astrocytes in Alzheimer’s Disease: Pathological Significance and Molecular Pathways

Cells, 2021
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer’s among others.
P. Preman, María Alfonso-Triguero, E. Alberdi, A. Verkhratsky, Amaia M. Arranz   +4 more
semanticscholar   +1 more source

Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells

Stem Cell Reports, 2018
Summary: Differentiation of astrocytes from human pluripotent stem cells (hPSCs) is a tedious and variable process. This hampers the study of hPSC-generated astrocytes in disease processes and drug development.
Xiang Li, Yezheng Tao, Robert Bradley, Zhongwei Du, Yunlong Tao, Linghai Kong, Yi Dong, Jeffrey Jones, Yuanwei Yan, Cole R.K. Harder, Lindsay Morgan Friedman, Magd Bilal, Brianna Hoffmann, Su-Chun Zhang   +13 more
doaj   +1 more source

Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function

Journal of Neuroinflammation, 2023
Background Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD).
Evangelos Konstantinidis, Benjamin Portal, Tobias Mothes, Chiara Beretta, Maria Lindskog, Anna Erlandsson   +5 more
doaj   +1 more source

Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy

Cells, 2022
Spinal muscular atrophy (SMA) is a motor neuron disorder leading to progressive loss of ventral horn neurons resulting in muscle wasting. Here we investigate the contribution of spinal astrocytes to the pathogenesis of late-onset SMA forms using a mouse ...
Markus Leo, Linda-Isabell Schmitt, Michael Fleischer, Rebecca Steffen, Cora Osswald, Christoph Kleinschnitz, Tim Hagenacker   +6 more
doaj   +1 more source

Astrocytes and Tinnitus

Brain Sciences
Tinnitus is correlated with anomalies of neural plasticity and has been found to be affected by inflammatory status. The current theories on tinnitus, although still somewhat incomplete, are based on maladaptive plasticity mechanisms. Astrocytes play a major role in both neural responses to inflammation and plasticity regulation; moreover, they have ...
Paola Perin, Roberto Pizzala
openaire   +4 more sources

Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release

Cells, 2019
Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in the central nervous system (CNS); however, residual glutamate in the extracellular space is, potentially, neurotoxic.
Shaimaa S. Mahmoud, M. Gharagozloo, Camille Simard, Denis Gris   +3 more
semanticscholar   +1 more source