Results 11 to 20 of about 108,129 (277)
Green Synthesis and Catalysis, 2021 We reported a synergistic Pd/Cu catalyzed enantioselective decarboxylative allylation of vinylethylene carbonates with glycine iminoesters, which provides facile access to non-proteinogenic diverse trisubstituted allylic amino acid derivatives in high ...
Miaolin Ke +4 more
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Continuous-Flow Synthesis of the Nucleobase Unit of Remdesivir
Engineering, 2023 In this work, the nucleobase unit of the antiviral drug remdesivir, 7-bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, was synthesized through five-step continuous flow.
Yongxing Guo +5 more
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Nickel-catalyzed direct stereoselective α-allylation of ketones with non-conjugated dienes
Nature Communications, 2023 The development of efficient and sustainable methods for the construction of carbon-carbon bonds with the simultaneous stereoselective generation of vicinal stereogenic centers is a longstanding goal in organic chemistry.
Yi-Xuan Cao +2 more
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Acta Pharmaceutica Sinica B, 2023 Our recent studies for nonnucleoside reverse transcriptase inhibitors identified a highly potent compound JK-4b against WT HIV-1 (EC50 = 1.0 nmol/L), but the poor metabolic stability in human liver microsomes (t1/2 = 14.6 min) and insufficient ...
Xin Jin +9 more
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Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability
Acta Pharmaceutica Sinica B, 2023 Considering the undesirable metabolic stability of our recently identified NNRTI 5 (t1/2 = 96 min) in human liver microsomes, we directed our efforts to improve its metabolic stability by introducing a new favorable hydroxymethyl side chain to the C-5 ...
Ya-Li Sang +4 more
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Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis
Green Synthesis and Catalysis, 2021 Hydroformylation of olefins can generate linear and branched aldehydes, and the branched aldehydes are attractive precursors for the synthesis of fine chemicals and pharmaceuticals.
Yingtang Ning +2 more
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Huiles essentielles et chiralité moléculaire
Comptes Rendus. Chimie, 2021 Molecular chirality is a property of the nature and life, it is present everywhere and at all scales of magnitude. A fundamental aspect of molecules that is generally overlooked in scientific aromatherapy yet based on the use of the chemistry of ...
Aribi-Zouioueche, Louisa +1 more
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Acta Pharmaceutica Sinica B, 2023 Following on our recently developed biphenyl-ATDP non-nucleoside reverse transcriptase inhibitor ZLM-66 (SI = 2019.80, S = 1.9 μg/mL), a series of novel heterocycle-substituted ATDP derivatives with significantly improved selectivity and solubility were ...
Li-Min Zhao +4 more
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Acta Pharmaceutica Sinica B, 2020 In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is ...
Kaijun Jin +6 more
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Supramolecular asymmetric catalysis mediated by crown ethers and related recognition systems
Green Synthesis and Catalysis, 2021 In the past decades, the combination of supramolecular chemistry and catalysis has pushed forward the emergence of supramolecular catalysis as an intersectant and challenging research field.
Zibin Zhang +5 more
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