Results 181 to 190 of about 24,420 (229)

AT1 receptor agonistic antibodies, hypertension, and preeclampsia

Seminars in Nephrology, 2004
Immunologic mechanisms and putatively circulating mediators of preeclampsia are not a new idea, but are nevertheless compelling. Here we review studies relating to the role of agonistic antibodies that bind the second extracellular loop of the angiotensin II (AII) AT1 receptor in the pathogenesis as well as a pathologic phenotype of this disorder ...
Ralf, Dechend, Dominik N, Müller, Gerd, Wallukat, Volker, Homuth, Manya, Krause, Joachim, Dudenhausen, Friedrich C, Luft   +6 more
openaire   +3 more sources

AT 1 Receptor Agonistic Antibodies From Preeclamptic Patients Stimulate NADPH Oxidase

Circulation, 2003
BACKGROUND: We recently identified agonistic autoantibodies directed against the angiotensin AT1 receptor (AT1-AA) in the plasma of preeclamptic women.
Ralf Dechend, Christiane Viedt, Dominik N Müller   +2 more
exaly   +2 more sources

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AT1 receptors as mechanosensors

Current Opinion in Pharmacology, 2011
G-protein-coupled receptors are appreciated as central components of neurohormonal signaling. Recently, it turned out that they may also play a role in mechanotransduction. The angiotensin II AT(1) receptor was the first G-protein-coupled receptor claimed to be a mechanosensor.
Michael, Mederos y Schnitzler, Ursula, Storch, Thomas, Gudermann   +2 more
openaire   +2 more sources

AT1 Receptor Antagonists

Current Medicinal Chemistry-Cardiovascular & Hematological Agents, 2004
Type 1 receptors (AT1) for the peptide hormone angiotensin II play a crucial role in the cardiovascular homeostasis. In this regard, several selective, orally active non-peptide antagonists have been developed for the treatment of hypertension and congestive heart failure.
I, Verheijen, P M L, Vanderheyden, J P, De Backer, G, Vauquelin   +3 more
openaire   +2 more sources

Molecular Cloning of AT1 Angiotensin Receptors

American Journal of Hypertension, 1992
Angiotensin II is the principal effector molecule of the renin-angiotensin system. Its effects are mediated by cell surface proteins termed AT receptors. On the basis of radioligand binding studies, these have been pharmacologically subdivided into two classes, termed AT1 receptors and AT2 binding sites (Chiu AT, et al, Biochem Biophys Res Commun 1989 ...
T J, Murphy, K, Takeuchi, R W, Alexander
openaire   +2 more sources

AT1 Receptor Interactions

2004
Angiotensin II and antagonist-AT1 receptor interactions have traditionally been studied on isolated tissues in organ bath experiments. Cells that express endogenous or transfected AT1 receptors are now also increasingly used to this end. Angiotensin II and angiotensin III interact with the AT1 receptor in a similar fashion.
Vauquelin, Georges, Vanderheyden, Patrick   +1 more
openaire   +2 more sources

Novel paramagnetic AT1 receptor antagonists

Chemical Communications, 2011
Novel paramagnetic selective angiotensin AT(1) receptor antagonists (sartans) bearing nitroxides (3, 4) have been prepared and their pharmacology evaluated in vitro as well as in vivo. Compounds 3, 4 proved to be effective sartans with pK(B) estimates in the range 6.2-9.1.
Nichole P H, Tan, Michelle K, Taylor, Steven E, Bottle, Christine E, Wright, James, Ziogas, Jonathan M, White, Carl H, Schiesser, Nitya V, Jani   +7 more
openaire   +3 more sources

Ontogeny of renin and AT1 receptor in the rat

Pediatric Nephrology, 1993
The enzyme renin and the angiotensin II (Ang II), subtype I receptor (ATI) are developmentally regulated in a tissue-specific manner. In early life, renin is expressed widely along the renal vasculature. As maturation progresses, there is a decrease in renin mRNA levels and a shift in the localization of renin close to the glomerulus.
R A, Gomez, A, Tufro-McReddie, A D, Everett, E S, Pentz   +3 more
openaire   +2 more sources