Results 191 to 200 of about 24,420 (229)
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2004
Clinical and experimental studies have demonstrated that AT1 receptor expression and regulation play an important role in the pathogenesis of cardiovascular diseases such as atherosclerosis and hypertension. The expression levels of the AT1 receptor define the biological efficacy of angiotensin II.
S. Wassmann, G. Nickenig
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Clinical and experimental studies have demonstrated that AT1 receptor expression and regulation play an important role in the pathogenesis of cardiovascular diseases such as atherosclerosis and hypertension. The expression levels of the AT1 receptor define the biological efficacy of angiotensin II.
S. Wassmann, G. Nickenig
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Human AT1 Receptor Gene Regulation
1996The peptide hormone angiotensin II (AII), the biologically active component of the renin-angiotensin system, regulates a variety of physiological responses including fluid homeostasis, aldosterone production, renal function and contraction of vascular smooth muscle (1).
B, Su, M M, Martin, T S, Elton
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International Journal of Molecular Medicine, 1998
Angiotensin II (Ang II), a potent modulator of cardiovascular homeostasis, mediates its effects through two Ang II receptor subtypes (AT1 and AT2) which share less than 30% amino acid homology and can be differentiated by specific nonpeptide ligands. We investigated the structural determinants of ligand binding to the AT1 receptor for L-163,017 which ...
K Sandberg +3 more
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Angiotensin II (Ang II), a potent modulator of cardiovascular homeostasis, mediates its effects through two Ang II receptor subtypes (AT1 and AT2) which share less than 30% amino acid homology and can be differentiated by specific nonpeptide ligands. We investigated the structural determinants of ligand binding to the AT1 receptor for L-163,017 which ...
K Sandberg +3 more
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Identification of AT1 Receptors on Cultured Astrocytes
1996It is well established that the brain contains an endogenous renin-angiotensin system (RAS) that participates in the regulation of blood pressure through the control of water intake and sodium appetite, the secretion of ACTH and Vasopressin and the regulation of sympathetic tone (1).
E A, Tallant, D I, Diz, C M, Ferrario
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Immunohistochemical mapping of angiotensin AT1 receptors in the brain
Regulatory Peptides, 1993A new approach to study angiotensin receptor distribution in the brain has been taken by developing antibodies to partial sequence of the angiotensin II (AII) type-1 receptor subtype (AT1) and demonstrating the presence of receptors with immunohistochemical staining.
Ian Phillips, M. +3 more
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1998
Angiotensin II (AngII) is a circulating and tissue peptide produced by the enzymatic cascade of the renin angiotensin system, which is in charge of regulating blood presure and hydromineral homeostasis. This octapeptide is generated by cleavage of the aminoterminus of the substrate angiotensinogen, a 60 kDa liver protein belonging to the serine ...
Stéphanie Miserey +6 more
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Angiotensin II (AngII) is a circulating and tissue peptide produced by the enzymatic cascade of the renin angiotensin system, which is in charge of regulating blood presure and hydromineral homeostasis. This octapeptide is generated by cleavage of the aminoterminus of the substrate angiotensinogen, a 60 kDa liver protein belonging to the serine ...
Stéphanie Miserey +6 more
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The ligand binding site of the angiotensin AT1 receptor
Trends in Pharmacological Sciences, 1996The angiotensin AT1 receptor mediates numerous physiological actions of the octapeptide hormone, angiotensin II, in its cardiovascular and other target tissues. The binding of angiotensin II to the AT1 receptor is dependent on both intramembrane and extracellular regions of the receptor molecule.
L, Hunyady, T, Balla, K J, Catt
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AT1 Receptor Molecular Aspects
2004In the past 12 years, cloning of the AngII AT1 receptor cDNA and gene have elucidated the primary structure of the protein, but also the structure of the mRNA and gene in different species. Using this cDNA as a tool, the different motifs and sequences involved in functions of the receptor has been established.
S. Conchon, E. Clauser
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Sympathetic Interactions of AT1 Receptors
2004The present chapter deals with the interaction between the renin-angiotensin system (RAS) and the sympathetic nervous system (SNS). Numerous studies have shown that (locally produced) angiotensin II (Ang II), the main effector of the RAS, can enhance sympathetic nervous transmission.
J. C. Balt, M. Pfaffendorf
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Binding of valsartan to mammalian angiotensin AT1 receptors
Regulatory Peptides, 1995The binding characteristics of the angiotensin AT1 receptor antagonist valsartan were investigated in different animal species and tissues. Using [125I](Sar1,Ile8) angiotensin II as radioligand, affinity constants were determined in liver and adrenal rat and marmoset, human adrenal and in rat aortic smooth muscle cells. In all tissues tested, valsartan
M, de Gasparo, S, Whitebread
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