Results 11 to 20 of about 13,112 (166)

Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation [PDF]

BMC Cancer, 2011
Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS could result in synergistic inhibition of colorectal cancer (CRC) liver metastases.Immediately following induction of CRC liver metastases through ...
Ager, EI, Wen, SW, Chan, J, Chong, WW, Neo, JH, Christophi, C   +5 more
openaire   +6 more sources

Interplay Between miR-155, AT1R A1166C Polymorphism, and AT1R Expression in Young Untreated Hypertensives [PDF]

American Journal of Hypertension, 2011
A silent polymorphism (+1166 A/C single-nucleotide polymorphism) localized in the 3'-UTR (untranslated region) of the human angiotensin II type-1 receptor (AT1R) has been associated with hypertension and cardiovascular complications. The +1166 A/C is recognized by a specific microRNA-155 (miR-155), which is base-pairing complementary with the +1166 A ...
CEOLOTTO, GIULIO, Papparella I, Bortoluzzi A, Strapazzon G, Ragazzo F, Bratti P, Fabricio AS, Squarcina E, Gion M, PALATINI, PAOLO, SEMPLICINI, ANDREA   +10 more
openaire   +3 more sources

AT1R–AT2R Cross Talk

, 2015
In vitro and in vivo studies have shown that angiotensin II type 1 receptor (AT1R) stimulation may regulate the expression of angiotensin II type 2 receptor (AT2R), suggesting the existence of a complex cross regulatory mechanism between the two subtype receptors.
Savoia, C., Volpe, M.
openaire   +2 more sources

AT1R gene rs389566 polymorphism contributes to MACCEs in hypertension patients

BMC Cardiovascular Disorders, 2023
Abstract Objective To investigate the possible association between AT1R gene polymorphisms and major adverse cardiovascular and cerebrovascular events (MACCEs) in hypertension patients combined with or without coronary artery disease (CAD) in Xinjiang.
Jun-Yi Luo, Guo-Li Du, Yang-Min Hao, Fen Liu, Tong Zhang, Bin-Bin Fang, Xiao-Mei Li, Xiao-Ming Gao, Yi-Ning Yang   +8 more
openaire   +4 more sources

ACE and AT1R gene polymorphisms and hypertension in Indian population [PDF]

Journal of Clinical Laboratory Analysis, 2000
The renin angiotensin system (RAS) controls intrarenal blood pressure and sodium balance, and is an important target for antihypertensive therapy. Several polymorphisms have been identified within genes encoding RAS that may contribute to the development of elevated blood pressure.
T F, Ashavaid, K K, Shalia, K G, Nair, J J, Dalal   +3 more
openaire   +3 more sources

Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: how common is the AT1R/B2R heterodimer?

The Journal of biological chemistry, 2008
Udgivelsesdato: 2008-Nov ...
Hansen, Jakob L, Hansen, Jonas T, Speerschneider, Tobias, Lyngsø, Christina, Erikstrup, Niels, Burstein, Ethan S, Weiner, David M, Walther, Thomas, Makita, Noriko, Iiri, Taroh, Merten, Nicole, Kostenis, Evi, Sheikh, Søren P   +12 more
openaire   +4 more sources

MAPK activation patterns of AT1R and CB1R in SHR versus Wistar astrocytes: Evidence of CB1R hypofunction and crosstalk between AT1R and CB1R

Cellular Signalling, 2017
Angiotensin (Ang) II and cannabinoids regulate physiologically relevant astroglial functions via receptor-mediated activation of Mitogen-activated protein kinases (MAPKs). In this study, we investigated the consequences of astroglial Ang II type 1 receptor (AT1R) and Cannabinoid type 1 receptor (CB1R) activation, alone and in combination, on MAPK ...
Haspula, Dhanush, Clark, Michelle A.
openaire   +4 more sources

Pathological AT1R-B2R Protein Aggregation and Preeclampsia [PDF]

Cells, 2021
Preeclampsia is one of the most frequent and severe complications of pregnancy. Symptoms of preeclampsia usually occur after 20 weeks of pregnancy and include hypertension and kidney dysfunction with proteinuria. Up to now, delivery of the infant has been the most effective and life-saving treatment to alleviate symptoms of preeclampsia because a ...
Quitterer, Ursula, AbdAlla, Said
openaire   +5 more sources

p100 increases AT1R expression through interaction with AT1R 3'-UTR [PDF]

Nucleic Acids Research, 2008
p100 protein (SND1, Tudor-SN) is a multifunctional protein that functions as a co-activator for several transcription factors, has a role in mRNA processing and participates in RNAi-induced silencing complex (RISC) with yet unknown function. In this study we identified a novel function for p100 as a regulator of angiotensin II type 1 receptor (AT1R ...
Paukku, Kirsi, Kalkkinen, Nisse, Silvennoinen, Olli, Kontula, Kimmo K., Lehtonen, Jukka Y. A.   +4 more
openaire   +2 more sources

A Limited Vs a Transient AT1R Internalization Indicates that Distinct Mechanisms of AT1R Activation are Possible

The FASEB Journal, 2021
We have shown that a 15,000 kDa polymer of Ang II (Ang II‐POL) at maximal concentration upon a sustained action on the AT1R of rat coronary endothelial luminal membrane (CELM) produced sustained vasoconstriction and inotropic effects, and a lack of CELM AT1R internalization.
Jesus Castillo‐Hernandez, Rafael Rubio, Martha Maldonado‐Cervantes   +2 more
openaire   +1 more source