Results 41 to 50 of about 13,112 (166)

Single-Molecule Imaging Reveals Differential AT1R Stoichiometry Change in Biased Signaling

, 2023
G protein-coupled receptors (GPCRs) represent promising therapeutic targets due to their involvement in numerous physiological processes mediated by downstream G protein- and β-arrestin-mediated signal transduction cascades.
Jiachao Xu, Yuxin Liang, Gege Qin, Xiaohong Fang   +3 more
core   +1 more source

Relaxation Time Mapping of Early‐Stage Osteonecrosis of the Femoral Head: An In Vivo Piglet Model Study

Journal of Orthopaedic Research, Volume 44, Issue 6, June 2026.
T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation time mapping techniques are sensitive in detecting ischemic injury to bone marrow of the femoral head in vivo in a piglet model at 3 T MRI. T2 and adiabatic T2ρ relaxation times have the most pronounced increase in ischemic versus perfused, contralateral‐control femoral heads 1 week after induction ...
Casey P. Johnson, Erick O. Buko, Sampada Bhave, Kayla L. Chase, Douglas Albrecht, Alexandra R. Armstrong, Jutta M. Ellermann, Harry K. W. Kim, Ferenc Tóth   +8 more
wiley   +1 more source

Neuroprotective Effects of Angiotensin II Type 1 Receptor (AT1R) Blocker, Telmisartan, via Modulating AT1R and AT2R Signaling in Retinal Inflammation

Investigative Opthalmology & Visual Science, 2006
To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU).The localization of AT1R and AT2R was shown by immunohistochemistry.
Toshihide, Kurihara, Yoko, Ozawa, Kei, Shinoda, Norihiro, Nagai, Makoto, Inoue, Yuichi, Oike, Kazuo, Tsubota, Susumu, Ishida, Hideyuki, Okano   +8 more
openaire   +2 more sources

AT1R blockade reduces IFN-γ production in lymphocytes in vivo and in vitro

, 2005
AT1R blockade reduces IFN-γ production in lymphocytes in vivo and in vitro.BackgroundType 1 angiotensin II (Ang II) receptor (AT1R) signaling induces proinflammatory responses.
Thekkumkara, Thomas J., Becker, Bryan N., Jacobson, Lynn M., Sprague, Jenifer, Weidanz, J.O.N. A., Djamali, Arjang, Wittman, Vaughan, Hullett, Debra A., Chiriva-Internati, Maurizio, Muehrer, Rebecca J.   +9 more
core   +1 more source

Non‐HLA Autoantibodies Associate With a Positive Flow‐Crossmatch Pre‐ and Chronic Lung Allograft Dysfunction Post‐ Lung Transplant

HLA, Volume 107, Issue 6, June 2026.
ABSTRACT Antibodies to HLA are a major cause of chronic lung allograft dysfunction (CLAD) following lung transplantation (LTx), however mounting evidence indicates non‐HLA autoantibodies may also play a role. LTx recipients may have increased autoantibodies related to their native disease, and these may impact both pre‐transplant assays and LTx ...
Steven Hiho, Alex Paporakis, Sadiaa Rahman, Bronwyn Levvey, Mary Diviney, Gregory Snell, Lucy Sullivan, Glen Westall   +7 more
wiley   +1 more source

Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre‐eclampsia

The Journal of Physiology, Volume 604, Issue 11, Page 4302-4317, 1 June 2026.
Abstract figure legend Excessive hypercholesterolaemia during pregnancy impairs maternal endothelial function, which, in turn, drives the development of pre‐eclampsia and may also contribute to the increased risk of later‐life cardiovascular disease in women.
Amanda A. de Oliveira, Floor Spaans, Christy‐Lynn M. Cooke, Sandra T. Davidge   +3 more
wiley   +1 more source

Protein Expressions of AT1R and AT2R in Aorta by Western Blot Analysis and Confocal Microscopy.

, 2014
Representative blots are shown for AT1R (A) and AT2R (B). The amounts of AT1R and AT2R were determined as the ratio of either AT1R (C) or AT2R (D) to β-actin.
Takahisa Miyamoto (133361), Toshiro Matsui (522163), Takahiro Kuroda (522160), Miki Kono (522161), Mitsuru Tanaka (522162), Toshihiko Fukuda (522159)   +5 more
core   +1 more source

Additional file 1 of Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma

, 2023
Additional file 1: Figure S1. MDK regulates AT1R and AT2R expression in HNSCC cell lines. A AT1R and AT2R expressions significantly increased while MDD overexpressed in the NHSCC cell line CAL27.
Tai-Jan Chiu (502558), Sheng‑Dean Luo (17037466), Ching-Shuen Wang (4567672), Yi-Ju Chen (213642), Chang-Han Chen (265692), Yinshen Wee (5316056)   +5 more
core   +1 more source

Unveiling protective mechanisms of wild olive (acebuche) oil in retinal pigment epithelial cells with hypertensive phenotype

The Journal of Physiology, Volume 604, Issue 11, Page 4166-4185, 1 June 2026.
Abstract figure legend Circulating extracellular vesicles (EVs) derived from acebuche (ACE) oil‐ and extra virgin olive oil (EVOO)‐fed mice modulate nitric oxide (NO) metabolism in the retinal pigment epithelial cell line (ARPE19) with a hypertensive phenotype induced by angiotensin II (AngII).
Álvaro Santana‐Garrido, Claudia Reyes‐Goya, Pablo Espinosa‐Martín, Rosa M. Troya‐Toledo, Helder André, Alfonso Mate, Carmen M. Vázquez   +6 more
wiley   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source