Results 61 to 70 of about 13,112 (166)
, 2023 Background and purpose: The renin-angiotensin system activation, partial ischemia/reperfusion (IR) injury, and hypertension contribute to the development of acute kidney injury.
Karimi, F. +3 more
core +1 more source
Anticorpo anti-AT1R em transplante pulmonar e seu potencial risco para o desenvolvimento de bronquiolite obliterante [PDF]
, 2012 Introdução: A presença de anticorpos (Ac) anti-HLA específicos contra o doador representam um potencial risco para o desenvolvimento de rejeição do enxerto pulmonar. Apesar de existirem evidências sobre a importância de anticorpos anti-receptor de tipo 1
Camargo, Spencer Marcantônio +1 more
core
Ligand-induced conformations of extracellular loop 2 of AT1R
, 2010 Angiotensin II type 1 receptor (AT1R) is a G-protein coupled receptor (GPCR) and an important regulator of blood pressure. It is a target for drug development, because abnormalities in its function are linked to hypertension, cardiac hypertrophy and ...
Unal, Hamiyet
core
Targeting Angiotensin II Type-1 Receptor (AT1R) Inhibits the Harmful Phenotype of Plasmodium-Specific CD8+ T Cells during Blood-Stage Malaria [PDF]
, 2017 CD8+ T-cell response is critical in the pathogenesis of cerebral malaria during blood-stage. Our group and other have been shown that angiotensin II (Ang II) and its receptor AT1 (AT1R), a key effector axis of renin-angiotensin system (RAS), have immune ...
João L. Silva-Filho +5 more
core +1 more source
, 2016 Cardiovascular complications represent the leading cause of death in chronic kidney disease (CKD) patients. Significant renal mass reduction induced by 5/6 subtotal nephrectomy (Nx) animal model leads to a chain of events that culminates in hypertension ...
Ismail, Basma
core +2 more sources
Role of anti-AT1R and anti-ETAR antibodies in pediatric kidney transplant rejection
, 2022 openIl trapianto renale rappresenta il trattamento d’elezione dell’insufficienza renale terminale pediatrica. Tuttavia, l’emivita d’organo è di 15-20 anni e una delle principali cause di perdita prematura è il rigetto anticorpo-mediato, causato dagli ...
ANTONIELLO, BENEDETTA
core
Distinct Phosphorylation Patterns of AT1R by Biased Ligands and GRK Subtypes
International Journal of Molecular SciencesG protein-coupled receptors (GPCRs) transmit through G proteins upon agonist activation, followed by phosphorylation by GPCR kinases (GRKs) to initiate β-arrestin signaling. However, the molecular mechanisms underlying GPCR signaling regulation by distinct agonists, GRK subtypes, and phosphorylation patterns remain poorly understood. The angiotensin II
Zisu Zhang +6 more
openaire +3 more sources
, 2008 Reactive oxygen species are thought to be critical inducers of renal inflammation and destruction. We examined the effects of candesartan, a highly selective angiotensin II type I receptor (AT1R) blocker, on renal inflammation and oxidative stress ...
Rifai, Abdalla +5 more
core +1 more source
β-Arrestin-biased AT1R stimulation promotes extracellular matrix synthesis in renal fibrosis
, 2017 The renin-angiotensin system plays a critical role in the progression of renal fibrosis. Angiotensin II type 1 receptor (AT1R) belongs to the B family of the G protein-coupled receptor (GPCR) family. β-Arrestins are known as negative regulators of GPCRs.
Jieli Huang +8 more
core +1 more source
The Expression of AT1R in Hypertensive Male and Female Rat Kidneys
, 2013 Hypertension is a risk factor for heart attacks and end stage kidney failure. Angiotensin II (AII) is a protein, which participates in the reabsorption of the filtered sodium from the lumen so it helps control Blood pressure.
Sainju, Sonika
core