Results 21 to 30 of about 13,112 (166)

Non‐HLA AT1R antibodies are highly prevalent after pediatric intestinal transplantation [PDF]

, 2021
The role of angiotensin II type-1 receptor (AT1R) antibodies in intestinal transplantation (ITx) is unclear. The aims were 1) to identify the prevalence of AT1R antibodies in pediatric ITx, compared to pediatric intestinal failure (IF), and 2) to ...
Laura J Wozniak, Farmer, Douglas G, Alvin P Chan, Suzanne V McDiarmid, Michelle J Hickey, Wozniak, Laura J, Rossetti, Maura, Elaine F Reed, Maura Rossetti, Douglas G Farmer, Elizabeth A Marcus, Guerra, Marjorie‐Anne R, Marjorie‐Anne R Guerra, Robert S Venick, Reed, Elaine F, Venick, Robert S, McDiarmid, Suzanne V, Hickey, Michelle J, Marcus, Elizabeth A, Chan, Alvin P   +19 more
core   +1 more source

Regulation of AT1R expression through HuR by insulin [PDF]

Nucleic Acids Research, 2012
Angiotensin II type 1 receptor (AT1R) has a pathophysiological role in hypertension, atherosclerosis and heart failure. Type 2 diabetes is hyperinsulinemic state and a major risk factor for atherosclerosis and hypertension. It is known that hyperinsulinemia upregulates AT1R expression post-transcriptionally by increasing the half-life of AT1R mRNA, but
Lehtonen Jukka Y. A., Kontula Kimmo K., Paukku Kirsi, Backlund Michael, Kalkkinen Nisse, Lehtonen Jukka Y. A., Kontula Kimmo K., Paukku Kirsi, Backlund Michael, Kalkkinen Nisse   +9 more
openaire   +3 more sources

Association between COVID-19 and AT1R-Ab.

, 2021
AT1R-Ab levels 15]. Solid lines indicate medians. Open circles are cases with known thrombosis. (A) There was a trend toward higher level of AT1R-Ab in all COVID-19 cases versus controls (median 9.8 vs 6.1, p = 0.06) and (B) significantly higher levels ...
Ana Gervassi (632929), Fergal Duffy (98254), Henry Kaplan (11719192), William Chour (11719168), Fred D. Mast (11719165), Jackson Wallner (11719177), Yonghou Jiang (1469449), Samantha Hardy (11719183), James R. Heath (467370), Jason D. Goldman (10005268), Alyssa Oldroyd (11719186), Ingrid Beck (465910), Micaela Haglund (11719174), Winnie Yeung (11719171), Julie A. Wallick (11719180), Andrew Raappana (11719162), Kim M. Murray (11719189), John Houck (132993), Blair Armistead (8334057), John D. Aitchison (102330), Lisa Frenkel (259393), D. Noah Sather (8911172), Whitney E. Harrington (10703740), Jennifer Hadlock (11719159), Daisy Ko (9300269), Leslie R. Miller (8808692), Venkata R. Duvvuri (8415780), Sheila Styrchak (357645)   +27 more
core   +1 more source

Structural overlap between SARS-CoV-2 Spike and AT1R.

, 2021
The structures of SARS-CoV-2 Spike (S1 and S2) and AT1R were aligned to assess potential homology. Overlap was identified between SARS-CoV-2 Spike (blue) in the S2 domain with the six-membered alpha-helical bundle of AT1R (purple), including the second ...
Ana Gervassi (632929), Fergal Duffy (98254), Henry Kaplan (11719192), William Chour (11719168), Fred D. Mast (11719165), Jackson Wallner (11719177), Yonghou Jiang (1469449), Samantha Hardy (11719183), James R. Heath (467370), Jason D. Goldman (10005268), Alyssa Oldroyd (11719186), Ingrid Beck (465910), Micaela Haglund (11719174), Winnie Yeung (11719171), Julie A. Wallick (11719180), Andrew Raappana (11719162), Kim M. Murray (11719189), John Houck (132993), Blair Armistead (8334057), John D. Aitchison (102330), Lisa Frenkel (259393), D. Noah Sather (8911172), Whitney E. Harrington (10703740), Jennifer Hadlock (11719159), Daisy Ko (9300269), Leslie R. Miller (8808692), Venkata R. Duvvuri (8415780), Sheila Styrchak (357645)   +27 more
core   +1 more source

The role of EGFR in vascular AT1R signaling : from cellular mechanisms to systemic relevance [PDF]

, 2023
The epidermal growth factor receptor (EGFR) belongs to the ErbB-family of receptor tyrosine kinases that are of importance in oncology. During the last years, substantial evidence accumulated for a crucial role of EGFR concerning the action of the ...
Dubourg, Virginie, Benndorf, Ralf, Schwerdt, Gerald, Schreier, Barbara, Gekle, Michael   +4 more
core   +1 more source

BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes [PDF]

Biochemical Pharmacology, 2018
The type 1 angiotensin II (AngII) receptor (AT1R) transactivates the epidermal growth factor receptor (EGFR), which leads to pathological remodeling of heart, blood vessels and kidney. End-point assays are used as surrogates of EGFR activation, however these downstream readouts are not applicable to live cells, in real-time.
Shannon L. O'Brien, Elizabeth K.M. Johnstone, Dominic Devost, Jacinta Conroy, Melissa E. Reichelt, Brooke W. Purdue, Mohammed A. Ayoub, Tatsuo Kawai, Asuka Inoue, Satoru Eguchi, Terence E. Hébert, Kevin D.G. Pfleger, Walter G. Thomas   +12 more
openaire   +4 more sources

Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma

, 2023
Background Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS) components. Angiotensin II is involved in tumor growth and angiogenesis in different cancers.
Yi-Ju Chen, Sheng‑Dean Luo, Ching-Shuen Wang, Chang-Han Chen, Yinshen Wee, Tai-Jan Chiu   +5 more
core   +1 more source

CaV1.2 Interaction with AT1R Reduces Receptor Internalization [PDF]

Biophysical Journal, 2016
The cardiac L type calcium channel is a multi-subunit complex that includes CaV1.2 as the pore-forming subunit that co-assembles with the auxiliary CaVa2d1 subunit and with the CaVb subunit. The main role of these auxiliary subunits is to modify the amount of channels inserted in the plasma membrane.
Hermosilla, Tamara, Encina, Matías, Moreno, Cristian, Morales, Danna, Salamanca, Edgardo, Hidalgo, Nayareth, Alfaro, Hilda, Varela, Diego   +7 more
openaire   +1 more source

AT1R A1166C variants in patients with type 2 diabetes mellitus and diabetic nephropathy [PDF]

, 2015
Background: There are inconsistent reports related to the role of angiotensin II type 1 receptor (AT1R) on the risk of type 2 diabetes mellitus (T2DM) and its renal complications.
Zohreh Rahimi, Sonia Amiri, Mahmood Vessal, Ziba Rahimi, Mahmoudreza Moradi, Hamid Nasri   +5 more
core   +1 more source

Effects of Dietary Potassium on Expression of AT1R and ATRAP [PDF]

Biophysical Journal, 2013
Previous studies have shown that potassium depletion enhances AT1 receptor density in the apical membrane, the basal membrane and nuclei of proximal tubular cells. The purpose of this study was to analyze the effect of high K+ intake and K+ depletion on Angiotensin II receptor (AT1R) and ATRAP (AT1R receptor-associated protein) expression on kidney ...
Adalgisa Neri, Elida, Duarte Queiroz-Leite, Gabriella, Rebouças, Nancy Amaral   +2 more
openaire   +1 more source