Results 101 to 110 of about 28,738 (248)

PPM1H is Down-Regulated by ATF6 and Dephosphorylates p-RPS6KB1 to Inhibit Progression of Hepatocellular Carcinoma [PDF]

, 2021
Xiaoshuang Yang, Jianting Guo, Wei Li, Chunrui Li, Xilin Zhu, Ying Liu, Xiaopan Wu   +6 more
openalex   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Transmission of ER stress response by ATF6 promotes endochondral bone growth [PDF]

Journal of Orthopaedic Surgery and Research, 2015
We reported earlier that X-box binding protein1 spliced (XBP1S), a key regulator of the unfolded protein response (UPR), as a bone morphogenetic protein 2 (BMP2)-inducible transcription factor, positively regulates endochondral bone formation by activating granulin-epithelin precursor (GEP) chondrogenic growth factor.
Xiong, Zhangyuan, Jiang, Rong, Zhang, Peng, Han, Xiaofeng, Guo, Feng-Jin   +4 more
openaire   +2 more sources

Molecular mechanism of ATF6 in unfolded protein response and its role in disease

Heliyon
Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, including diseases such as congenital retinal disease, liver fibrosis and ankylosing ...
Yingying Lei, Hong Yu, Shaoxue Ding, Hui Liu, Chunyan Liu, Rong Fu   +5 more
doaj   +1 more source

EXPRESSION OF ENDOPLASMIC RETICULUM OXIDOREDUCTASES (EROS) AND THEIR ROLE IN THE GI TRACT [PDF]

, 2012
It has been shown that some ER redox enzymes are differentially expressed in stomach and oesophagus tissue. The tissues of the gastrointestinal system, which are subject to external changes of environment during the process of digestion, represent a ...
WATSON, GRAEME
core  

12-h clock regulation of genetic information flow by XBP1s [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S., Abdurehman, L., York, B., Chen, X., Schnytzer,
Abdurehman, Leymaan, Ballance, Heather, Chen, Xi, Dacso, Clifford C., Gonzalez, Naomi, Kim, Sam-Moon, Levy, Oren, Liu, Silvia, McClung, Colleen A., Meng, Huan, O’Malley, Bert W., Pan, Yinghong, Schnytzer, Yisrael, York, Brian, Zhu, Bokai   +14 more
core   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Endoproteolysis of the ER Stress Transducer ATF6 in the Presence of Functionally Inactive Presenilins

Neurobiology of Disease, 2001
Presenilin (PS) proteins facilitate endoproteolysis of selected type I transmembrane proteins such as the Alzheimer's disease (AD) associated β-Amyloid precursor protein (βAPP) and Notch.
Harald Steiner, Edith Winkler, Mark S. Shearman, Ron Prywes, Christian Haass   +4 more
doaj   +1 more source

Placental growth factor inhibition modulates the interplay between hypoxia and unfolded protein response in hepatocellular carcinoma [PDF]

, 2016
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality. We previously showed that the inhibition of placental growth factor (PlGF) exerts antitumour effects and induces vessel normalisation, possibly reducing hypoxia ...
Bogaerts, Eliene, Carmeliet, Peter, Devisscher, Lindsey, Geerts, Anja, Jonckx, Bart, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van den Bussche, Anja, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Verhelst, Xavier   +13 more
core   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen, Sheng Xu, Bingrong Chen, Xishan Xiong, Jinrui Hu, Yuhong Wu, Tianrui Wang, Huishang Wang   +7 more
wiley   +1 more source