Results 101 to 110 of about 29,072 (277)

How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]

, 2017
Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias, Mukherjee, Shaeri, Schlaermann, Philipp   +2 more
core   +2 more sources

Polymorphism in asparagine synthetase is associated with overall survival of hepatocellular carcinoma patients

BMC Gastroenterology, 2017
Background Recently, it is reported that asparagine synthetase (ASNS) is an independent predictor of surgical survival in hepatocellular carcinoma (HCC) patients.
Wei Li, Chengwei Dong
doaj   +1 more source

OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress

Cancer Science, 2021
The unfolded protein response (UPR) plays an important role in carcinogenesis, but the functional role and mechanism of UPR‐associated bladder carcinogenesis remain to be characterized.
Hui-Hui Zhang, Chao Li, Jian-Wei Ren, Lian Liu, Xue-Hua Du, Jie Gao, Tao Liu, Shang-Ze Li   +7 more
semanticscholar   +1 more source

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source

Repression of viral gene expression and replication by the unfolded protein response effector XBP1u

eLife, 2020
The unfolded protein response (UPR) is a cellular homeostatic circuit regulating protein synthesis and processing in the ER by three ER-to-nucleus signaling pathways. One pathway is triggered by the inositol-requiring enzyme 1 (IRE1), which splices the X-
Florian Hinte, Eelco van Anken, Boaz Tirosh, Wolfram Brune   +3 more
doaj   +1 more source

Endoplasmic Reticulum Stress Amplifies Cytokine Responses in Astrocytes via a PERK/eIF2α/JAK1 Signaling Axis

Glia, EarlyView.
ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri, Savannah G. Sims, Jessica A. Herstine, Alicia Meyer, Micah J. Marshall, Ishrat Jahan, Subhodip Adhicary, Allison M. Bradbury, Gordon P. Meares   +8 more
wiley   +1 more source

miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6. [PDF]

, 2015
Background MicroRNA (miRNA) and messenger RNA (mRNA) expression differs in cystic fibrosis (CF) versus non-CF bronchial epithelium. Here, the role of miRNA in basal regulation of the transcription factor ATF6 was investigated in bronchial epithelial ...
Agrawal, Raman, Greene, Catherine M, Mall, Marcus A, McElvaney, Noel G, Oglesby, Irene K   +4 more
core   +2 more sources

Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated apoptotic cell death in liver cancer cells

Journal of International Medical Research, 2020
Objective Titanium oxide (TiO 2 ) acts as a photosensitizer in photodynamic therapy by mediating reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress.
Zhiwang Li, Jingliang He, Bowei Li, Jinqian Zhang, Ke He, Xiaopeng Duan, Rui Huang, Zuguang Wu, Guoan Xiang   +8 more
doaj   +1 more source

Endothelial cells, endoplasmic reticulum stress and oxysterols [PDF]

, 2017
Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis.
Canonico, B., Cesarini, E., Crinelli, R., Di Sario, G., Guidi, L., Iuliano, Luigi, Luchetti, F, Magnani, M., Papa, S., Zamai, L., Zerbinati, C.   +10 more
core   +3 more sources

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, EarlyView.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source