Results 131 to 140 of about 28,738 (248)

Lycium barbarum polysaccharide ameliorates the accumulation of lipid droplets in adipose tissue via an ATF6/SIRT1-dependent mechanism

Acta Biochimica et Biophysica Sinica
Lipid droplets (LDs) are dynamic organelles that store neutral lipids and are closely linked to obesity. Previous studies have suggested that Lycium barbarum polysaccharide (LBP) supplements can ameliorate obesity, but the underlying
Zhou Rui, Liu Yajing, Hu Weiqian, Yang Jing, Lin Bing, Zhang Zhentian, Chen Mingyan, Yi Jingwen, Zhu Cuifeng   +8 more
doaj   +1 more source

Reaction to Endoplasmic Reticulum Stress via ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging

Frontiers in Aging Neuroscience, 2019
Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a “window to the central nervous system” we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-
Tino Prell, Tino Prell, Beatrice Stubendorff, Thanh Tu Le, Nayana Gaur, Vedrana Tadić, Annekathrin Rödiger, Otto W. Witte, Otto W. Witte, Julian Grosskreutz, Julian Grosskreutz   +10 more
doaj   +1 more source

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance

Cell Reports, 2016
Defective insulin signaling in hepatocytes is a key factor in type 2 diabetes. In obesity, activation of calcium/calmodulin-dependent protein kinase II (CaMKII) in hepatocytes suppresses ATF6, which triggers a PERK-ATF4-TRB3 pathway that disrupts insulin
Lale Ozcan, Devram S. Ghorpade, Ze Zheng, Jane Cristina de Souza, Ke Chen, Marc Bessler, Melissa Bagloo, Beth Schrope, Richard Pestell, Ira Tabas   +9 more
doaj   +1 more source

Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnfα transcription

International Journal of Oral Science
Corticotomy is a clinical procedure to accelerate orthodontic tooth movement characterized by the regional acceleratory phenomenon (RAP). Despite its therapeutic effects, the surgical risk and unclear mechanism hamper the clinical application.
Zhichun Jin, Hao Xu, Weiye Zhao, Kejia Zhang, Shengnan Wu, Chuanjun Shu, Linlin Zhu, Yan Wang, Lin Wang, Hanwen Zhang, Bin Yan   +10 more
doaj   +1 more source

Hepatic rhythmicity of endoplasmic reticulum stress is disrupted in perinatal and adult mice models of high-fat diet-induced obesity [PDF]

, 2016
We investigated the regulation of hepatic ER stress in healthy liver and adult or perinatally programmed diet-induced non-alcoholic fatty liver disease (NAFLD).
Asilmaz, E, Carter, R, Cordero, P, Li, J, Mouralidarane, A, Nguyen, V, Novelli, M, Oben, J, Poston, L, Ray, S, Soeda, J, Taylor, PD, Vinciguerra, M   +12 more
core   +1 more source

The Distribution of Activating Transcription Factor 6 (ATF6) and Nerve Growth Factor (NGF) in the Duodenum Tissue of Diabetic and Non-Diabetic Rats

, 2021
Şükran Yedi̇el Aras, Ebru KARADAĞ SARI, Serpil DAĞ   +2 more
openalex   +2 more sources

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors [PDF]

, 2022
Meng Wang, Edmund Cotter, Yajuan Wang, Xu Fu, Angela L. Whittsette, Joseph W. Lynch, R. Luke Wiseman, Jeffery W. Kelly, Angelo Keramidas, Ting‐Wei Mu   +9 more
openalex   +1 more source

A deafness-blindness syndrome results from ATF6-based disruption of the unfolded protein response

The Journal of Clinical Investigation
Sensorineural hearing loss (SNHL) is the most prevalent form of permanent hearing impairment, arising from factors such as aging, exposure to loud noise, disease, ototoxic medications, and genetic mutations.
Yuvraj Joshi, Jeffrey N. Savas
doaj   +1 more source

AtMYB72 as a Biotechnological Tool to Overcome Phenylpropanoid Substrate Limitation and Enhance Coumarin Biosynthesis in Plants

Plant Biotechnology Journal, EarlyView.
Jakob Weber Böhlen, Alexander Beesley, Sebastian F. Beyer, Patrick Schwinges, Alina E. Maas, Holger Schultheiss, Uwe Conrath, Caspar J. G. Langenbach   +7 more
wiley   +1 more source

Echinacoside inhibited cardiomyocyte apoptosis and improved heart function in heart failure rats induced by isoproterenol via suppressing nadph/ros/atf6/chop associated endoplasmic reticulum stress [PDF]

, 2022
Ya-Juan Ni, Lan Gao, Wenhua Zhu
openalex   +1 more source