Results 131 to 140 of about 29,072 (277)

Comparative Analysis of Heat Exposure‐Induced Molecular Changes in Two Turtle Species with Contrasting Thermal Adaptations

Integrative Zoology, EarlyView.
Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong, Yangchun Gao, Jiaxuan Li, Yan Ge, Yufeng Wei, Youqiang Yin, Qianru Liang, Shiping Gong   +7 more
wiley   +1 more source

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

ER stress‐related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer

Molecular Oncology, 2018
Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to contribute to ...
Chun‐Yu Liu, Chia‐Chi Hsu, Tzu‐Ting Huang, Chia‐Han Lee, Ji‐Lin Chen, Shung‐Haur Yang, Jeng‐Kai Jiang, Wei‐Shone Chen, Kuan‐Der Lee, Hao‐Wei Teng   +9 more
doaj   +1 more source

ATF6 regulates the development of chronic pancreatitis by inducing p53-mediated apoptosis [PDF]

Cell Death & Disease, 2019
AbstractChronic pancreatitis (CP) is a progressive, recurrent inflammatory disorder of the pancreas. Initiation and progression of CP can result from serine protease 1 (PRSS1) overaccumulation and the ensuing endoplasmic reticulum (ER) stress. However, how ER stress pathways regulate the development and progression of CP remains poorly understood.
Xue-mei Chen, Su-ying Zhou, Su-bing Li, Lei Zhou, Jia Xu, Qi-xin Mo, Zhi-wei Li, Guo-wei Zhang, Zhao-chang Qi, Rong-chang Cao, Jie-hui Tan   +10 more
openaire   +2 more sources

Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Endoplasmic reticulum (ER) stress is a crucial pathogenic mechanism in alcoholic liver disease (ALD). B‐cell receptor‐associated protein 31 (BAP31) can regulate ER homeostasis and anti‐apoptosis, but the function and regulation of BAP31 in ALD are unclear.
Sai Wang, Yufeng Wang, Wen Shan, Guoyang Li, Ran Yan, Zhecheng Wang, Yan Zhao, Jihong Yao, Ning Zhang   +8 more
wiley   +1 more source

A conformational RNA zipper promotes intron ejection during non-conventional XBP1 mRNA splicing. [PDF]

, 2015
The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER).
Acosta-Alvear, Diego, Mendez, Aaron S, Peschek, Jirka, Walter, Peter   +3 more
core   +1 more source

Loss of β‐cell identity in human islets treated with glibenclamide

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Loss of β‐cell identity can contribute to the reduction of functional β‐cell mass in type 2 diabetes. Sulfonylureas show shorter durability of antihyperglycaemic action and higher rates of secondary failure compared to other antihyperglycaemic agents, suggesting that they could accelerate the decline of β‐cell functional mass in type 2 ...
Claudia Fernández, Montserrat Nacher, Kevin Rivera, Sandra Marín‐Cañas, Maria Sorribas, Gabriel Moreno‐González, Elisabet Estil·les, Patricia San José, Noèlia Téllez, Eduard Montanya   +9 more
wiley   +1 more source

Reaction to Endoplasmic Reticulum Stress via ATF6 in Amyotrophic Lateral Sclerosis Deteriorates With Aging

Frontiers in Aging Neuroscience, 2019
Amyotrophic lateral sclerosis (ALS) is a multisystemic neurodegenerative disorder. Given that peripheral blood mononuclear cells (PBMCs) serve as a “window to the central nervous system” we aimed to answer whether endoplasmic reticulum (ER) stress in ALS-
Tino Prell, Tino Prell, Beatrice Stubendorff, Thanh Tu Le, Nayana Gaur, Vedrana Tadić, Annekathrin Rödiger, Otto W. Witte, Otto W. Witte, Julian Grosskreutz, Julian Grosskreutz   +10 more
doaj   +1 more source

ATF6 ubiquitylation is required for its transcriptional activity and degradation

The FASEB Journal, 2018
IntroductionATF6α is an endoplasmic reticulum (ER) transmembrane protein that senses the accumulation of misfolded proteins in the ER of cells during ER stress. Upon ER stress, ATF6α is proteolytically cleaved. The resulting N‐terminal fragment becomes an active transcription factor, i.e.
Christopher C. Glembotski, Cathrine Aivati, Donna J. Thuerauf   +2 more
openaire   +1 more source

Nitrate Prevents Sjögren's Disease by Modulating T Helper Cells via NF‐κB Pathway Suppression

Oral Diseases, EarlyView.
ABSTRACT Objective Sjögren's disease (SjD) is a chronic autoimmune disease characterized by abnormal T helper (Th) cell distribution in the salivary glands (SGs). Although nitrate can regulate immune responses and preserve SGs function, its preventive effects on SjD remain unexplored.
Conglin Du, Zi Yang, Yang Yang, Chunmei Zhang, Hideaki Kagami, Xianqi Li, Liang Hu, Junji Xu, Jian Zhou   +8 more
wiley   +1 more source