Results 71 to 80 of about 29,072 (277)

Mutation of ATF6 causes autosomal recessive achromatopsia [PDF]

Human Genetics, 2015
Achromatopsia (ACHM) is an early-onset retinal dystrophy characterized by photophobia, nystagmus, color blindness and severely reduced visual acuity. Currently mutations in five genes CNGA3, CNGB3, GNAT2, PDE6C and PDE6H have been implicated in ACHM. We performed homozygosity mapping and linkage analysis in a consanguineous Pakistani ACHM family and ...
Muhammad Ansar, Suzanne M. Leal, Huma Qureshi, Fareeha Zulfiqar, Kwanghyuk Lee, Naeem Mahmood Ashraf, Ehsan Ullah, Xin Wang, Sundus Sajid, Falak Sher Khan, Muhammad Aminuddin, Joshua D. Smith, Jay Shendure, Michael J. Bamshad, Deborah A. Nickerson, Abdul Hameed, Saima Riazuddin, Zubair M. Ahmed, Wasim Ahmad, Suzanne M. Leal   +19 more
openaire   +3 more sources

Cancer microenvironment and endoplasmic reticulum stress response [PDF]

, 2015
Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR).
Conti, S, Facchiano, A, Filippini, Antonio, Giampietri, Claudia, Petrungaro, Simonetta, Ziparo, Elio   +5 more
core   +4 more sources

Hyperglycemia-triggered ATF6-CHOP pathway aggravates acute inflammatory liver injury by β-catenin signaling

Cell Death Discovery, 2022
Although hyperglycemia has been documented as an unfavorable element that can further induce liver ischemia–reperfusion injury (IRI), the related molecular mechanisms remain to be clearly elaborated.
Chao Yang, Zeng Wang, Yuanchang Hu, Shikun Yang, F. Cheng, J. Rao, Xuehao Wang   +6 more
semanticscholar   +1 more source

Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]

, 2017
Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A, Haj, Fawaz G, Passerini, Anthony G, Simon, Scott I   +3 more
core   +1 more source

Melatonin Protects Against Neuronal Apoptosis via Suppression of the ATF6/CHOP Pathway in a Rat Model of Intracerebral Hemorrhage

Frontiers in Neuroscience, 2018
Neuronal apoptosis is an important factor accounting for the poor outcomes of intracerebral hemorrhage (ICH). This study first showed that inhibition of activating transcription factor 6 (ATF6) could alleviate secondary brain injury through anti ...
Weilin Xu, Xiaoyang Lu, Jingwei Zheng, Tao Li, Liansheng Gao, Cameron Lenahan, Anwen Shao, Jianmin Zhang, Jianmin Zhang, Jianmin Zhang, Jun Yu   +10 more
doaj   +1 more source

Melatonin relieves heat-induced spermatocyte apoptosis in mouse testes by inhibition of ATF6 and PERK signaling pathways

Zoological Research, 2021
Normal spermatogenic processes require the scrotal temperature to be lower than that of the body as excessive heat affects spermatogenesis in the testes, reduces sperm quality and quantity, and even causes infertility.
Dehua Qin, Hui Cai, Chen He, Donghui Yang, Jing Sun, Wenlai He, Balun Li, Jin-lian Hua, S. Peng   +8 more
semanticscholar   +1 more source

Consensus clustering and functional interpretation of gene-expression data [PDF]

, 2004
Microarray analysis using clustering algorithms can suffer from lack of inter-method consistency in assigning related gene-expression profiles to clusters.
Kellam, P., Liu, X., Martin, Nigel, Orengo, C.A., Swift, S., Tucker, A., Vinciotti, V.   +6 more
core   +2 more sources

Toll-like receptor 4-mediated endoplasmic reticulum stress induces intestinal paneth cell damage in mice following CLP-induced sepsis

Scientific Reports, 2022
A marked elevation of TLR4 was observed in various organs of septic mice. The mechanism of TLR4 in intestinal epithelial cell damage in sepsis remains unclear.
Yijie Wang, Dapeng Zhang, Congxin Li, Xue Wu, Chen He, Xiaolin Zhu, Haiyan Zhao, Lingjie Mu   +7 more
doaj   +1 more source

p62-Induced Cancer-Associated Fibroblast Activation via the Nrf2-ATF6 Pathway Promotes Lung Tumorigenesis

Cancers, 2021
Simple Summary Cancer-associated fibroblasts (CAF) arise from normal fibroblasts within the tumor microenvironment (TME) and promote tumorigenesis through metabolic reprograming and secretion of tumor promoting molecules such as transforming growth ...
J. Kang, Dong Hyun Kim, Ki Woon Sung, S. Shim, H. Cha-Molstad, N. Soung, K. H. Lee, Joonsung Hwang, Hee-Gu Lee, Y. Kwon, Bo Yeon Kim   +10 more
semanticscholar   +1 more source

The Unfolded Protein Response and its potential role in Huntington's disease [PDF]

, 2012
Huntington's disease (HD) is a progressive, neurodegenerative disease with fatal outcome. Although the disease-causing gene (huntingtin) has been known for some time, the exact cause of neuronal cell death is still unknown.
Kamesh Ayasolla, Matthias E. Futschik, Ravi K. R. Kalathur   +2 more
core   +2 more sources