Results 81 to 90 of about 29,072 (277)

ATF6 aggravates angiogenesis-osteogenesis coupling during ankylosing spondylitis by mediating FGF2 expression in chondrocytes

iScience, 2021
Summary: Although angiogenesis-osteogenesis coupling is important in ankylosing spondylitis (AS), therapeutic agents targeting the vasculature remain elusive.
Mengjun Ma, Hongyu Li, Peng Wang, Wen Yang, Rujia Mi, Jiahao Zhuang, Yuhang Jiang, Yixuan Lu, Xin Shen, Yanfeng Wu, Huiyong Shen   +10 more
doaj  

The non-canonical mechanism of ER stress-mediated progression of prostate cancer

Journal of Experimental & Clinical Cancer Research, 2021
Background The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing.
Artem N. Pachikov, Ryan R. Gough, Caroline E. Christy, Mary E. Morris, Carol A. Casey, Chad A. LaGrange, Ganapati Bhat, Anatoly V. Kubyshkin, Iryna I. Fomochkina, Evgeniya Y. Zyablitskaya, Tatiana P. Makalish, Elena P. Golubinskaya, Kateryna A. Davydenko, Sergey N. Eremenko, Jean-Jack M. Riethoven, Amith S. Maroli, Thomas S. Payne, Robert Powers, Alexander Y. Lushnikov, Amanda J. Macke, Armen Petrosyan   +20 more
doaj   +1 more source

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells [PDF]

, 2018
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK)
Contreras Bernal, Laura, Cruz Díaz, Jesús de la, Gallego, Paloma, González, Raúl, Navarro Villarán, Elena, Ordóñez, Raquel, Rodríguez Arribas, M., Rodríguez Hernández, María A., Rosa, Ángel J. de la   +8 more
core   +1 more source

The endoplasmic reticulum in plant immunity and cell death [PDF]

, 2012
The endoplasmic reticulum (ER) is a highly dynamic organelle in eukaryotic cells and a major production site of proteins destined for vacuoles, the plasma membrane, or apoplast in plants.
Eichmann, Ruth, Schäfer, P. (Patrick)
core   +2 more sources

Hugan Qingzhi tablets attenuates endoplasmic reticulum stress in nonalcoholic fatty liver disease rats by regulating PERK and ATF6 pathways

BMC Complementary Medicine and Therapies
Background Endoplasmic reticulum (ER) stress, promoting lipid metabolism disorders and steatohepatitis, contributes significantly to the pathogenesis of nonalcoholic fatty liver disease (NAFLD).
Miaoting Yang, X. Yao, F. Xia, Shijian Xiang, Waijiao Tang, Benjie Zhou   +5 more
semanticscholar   +1 more source

ER Stress Activates the TOR Pathway through Atf6

Journal of Molecular Signaling, 2018
Cellular signaling pathways are often interconnected. They accurately and efficiently regulate essential cell functions such as protein synthesis, cell growth, and survival. The target of rapamycin (TOR) signaling pathway and the endoplasmic reticulum (ER) stress response pathway regulate similar cellular processes.
Dylan Allen, Jin Seo
openaire   +5 more sources

A Systems Biology Approach towards Deciphering the Unfolded Protein Response in Huntington's Disease [PDF]

, 2012
Although the disease causing gene huntingtin has been known for some time, the exact cause of neuronal cell death during _Huntington's disease_ (HD) remains unknown.
Kameshwar R. Ayasolla, Matthias E. Futschik, Ravi K. R. Kalathur   +2 more
core   +2 more sources

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

eLife, 2016
Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-diverse degenerative diseases linked to excessive extracellular protein misfolding and aggregation.
Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher, Franck Madoux, Joseph C Genereux, Wesley Dobbs, Dan Garza, Timothy P Spicer, Louis Scampavia, Steven J Brown, Hugh Rosen, Evan T Powers, Peter Walter, Peter Hodder, R Luke Wiseman, Jeffery W Kelly   +17 more
doaj   +1 more source

12-h clock regulation of genetic information flow by XBP1s [PDF]

, 2020
© The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S., Abdurehman, L., York, B., Chen, X., Schnytzer,
Abdurehman, Leymaan, Ballance, Heather, Chen, Xi, Dacso, Clifford C., Gonzalez, Naomi, Kim, Sam-Moon, Levy, Oren, Liu, Silvia, McClung, Colleen A., Meng, Huan, O’Malley, Bert W., Pan, Yinghong, Schnytzer, Yisrael, York, Brian, Zhu, Bokai   +14 more
core   +1 more source

Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism

Cellular Physiology and Biochemistry, 2018
Background/Aims: Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, and an increased accumulation of LDs in the liver is closely linked to hepatic steatosis.
Rui Zhou, Long Yi, Xikun Ye, Xianglong Zeng, Kai Liu, Yu Qin, Qianyong Zhang, Mantian Mi   +7 more
doaj   +1 more source