Results 131 to 140 of about 18,950 (216)

Two distinct regulatory pathways govern Cct2-Atg8 binding in the process of solid aggrephagy

EMBO Reports
CCT2 serves as an aggrephagy receptor that plays a crucial role in the clearance of solid aggregates, yet the underlying molecular mechanisms by which CCT2 regulates solid aggrephagy are not fully understood.
Yuting Chen, Zhaojie Liu, Yi Zhang, Miao Ye, Yingcong Chen, Jianhua Gao, Juan Song, Huan Yang, Choufei Wu, Weijing Yao, Xue Bai, Mingzhu Fan, Shan Feng, Yigang Wang, Liqin Zhang, Liang Ge, Du Feng, Cong Yi   +17 more
doaj   +1 more source

HLS1 interacts with ATG8 to negatively regulate the ABS3-mediated plant senescence pathway

Cell Reports
Summary: In Arabidopsis, late endosome-localized ABNORMAL SHOOT 3 (ABS3) promotes senescence through a direct interaction with AUTOPHAGY8 (ATG8). However, the molecular mechanisms underlying the regulation of the ABS3-mediated senescence pathway are not ...
Pei Lei, Zhaoliang Zhang, Xue An, Lixuan Feng, Xiao Shen, Hui Xue, Liangchen Xu, Jingxia Shao, Fei Yu, Xiayan Liu   +9 more
doaj   +1 more source

Transcription Factor Deformed Wings Is an Atg8a-Interacting Protein That Regulates Autophagy

Cells
LC3 (microtubule-associated protein 1 light chain 3, called Atg8 in yeast and Drosophila) is one of the most well-studied autophagy-related proteins. LC3 controls the selectivity of autophagic degradation by interacting with LIR (LC3-interacting region ...
Marta Kołodziej, Panagiotis Tsapras, Alexander D. Cameron, Ioannis P. Nezis   +3 more
doaj   +1 more source

Multiplex genomic tagging of mammalian ATG8s to study autophagy

Journal of Biological Chemistry
Atg8 proteins play a crucial role in autophagy. There is a single Atg8 isoform in yeast, while mammals have up to seven homologs categorized into LC3s and GABARAPs. The GABARAP subfamily consists of GABARAP, GABARAPL1, and GABARAPL2/GATE16, implicated in various stages along the pathway.
Korina Goldin-Azulay, Milana Fraiberg, Olena Trofimyuk, Yishai Levin, Nina Reuven, Ekaterina Kopitman, Zvulun Elazar   +6 more
openaire   +2 more sources

Morbus Crohn—a disease of failing macroautophagy in the immune system? [PDF]

, 2017
Mutations in genes involved in macroautophagy have been found to be associated with Morbus Crohn, also called Crohn's disease (CD), an inflammatory bowel disease.
Meixlsperger, Sonja, Münz, Christian
core  

Characterization of ATG8-family protein phosphorylation by Phos-tag gel for autophagy study

STAR Protocols
Summary: Autophagy supports cell survival under different stress conditions, where ATG8-family proteins are required for autophagosome biogenesis/maturation and selective autophagy.
Gayoung Seo, Wenqi Wang
doaj   +1 more source

Discovery of Evolutionary Loss of the Ubiquitin-like Autophagy-Related ATG12 System in a Lineage of Apicomplexa

Cells
The autophagy-related ubiquitin-like conjugation systems, the ATG8 and ATG12 systems, are universally conserved in eukaryotes. However, the covalent bond in the ATG12 system has recently been shown to be evolutionarily lost in Apicomplexa.
Xiaoxia X. Lin, Yun D. Bai, Sichang T. Wang, Akira Nozawa, Tatsuya Sawasaki, Tatsunori Masatani, Kenji Hikosaka, Masahito Asada, Hirokazu Sakamoto   +8 more
doaj   +1 more source

Lysosome-associated CASM: from upstream triggers to downstream effector mechanisms

Frontiers in Cell and Developmental Biology
Lysosomes are dynamic organelles critical for cellular degradation and signaling, safeguarded by a limiting membrane that prevents leakage of harmful contents into the cytoplasm.
Namrita Kaur, Namrita Kaur, Sven R. Carlsson, Alf Håkon Lystad, Alf Håkon Lystad   +4 more
doaj   +1 more source

Nonuple atg8 mutant provides genetic evidence for functional specialization of ATG8 isoforms inArabidopsis thaliana

AbstractAutophagy sustains cellular health by recycling damaged or excess components through autophagosomes. It is mediated by conserved ATG proteins, which coordinate autophagosome biogenesis and selective cargo degradation. Among these, the ubiquitin-like ATG8 protein plays a central role by linking cargo to the growing autophagosomes through ...
Alessia Del Chiaro, Nenad Grujic, Jierui Zhao, Ranjith Kumar Papareddy, Peng Gao, Juncai Ma, Christian Lofke, Anuradha Bhattacharya, Ramona Gruetzner, Pierre Bourguet, Frédéric Berger, Byung-Ho Kang, Sylvestre Marillonnet, Yasin Dagdas   +13 more
openaire   +1 more source

The Human Autophagy Core Complexes. [PDF]

Annu Rev Biochem
Hurley JH.
europepmc   +1 more source