Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy [PDF]
, 2011 Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin ...
Anh H. Pham +49 more
core +3 more sources
(Poly)phenol-digested metabolites modulate alpha-synuclein toxicity by regulating proteostasis [PDF]
, 2018 We acknowledge Rita Ramos for support with qRT-PCR and Regina Menezes for the selection of primers; Antonio Temudo and Ana M. Nascimento for imaging support; The IMM-JLA Flow Cytometry Facility. We also thank Prof.
Almeida, A. Filipa +10 more
core +4 more sources
Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation
Nature Communications, 2017 The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated.
Jana Sánchez-Wandelmer +13 more
doaj +1 more source
The autophagosome:current understanding of formation and maturation [PDF]
, 2015 Autophagy is an important and highly conserved catabolic process with roles in development, homeostasis, and cellular stress responses. It describes various distinct pathways for the delivery of cytoplasmic materials (including misfolded protein ...
Lane, Jon D, Mannack, Lilith V J
core +2 more sources
Genotype-Specific Activation of Autophagy during Heat Wave in Wheat
CellsRecycling of unnecessary or dysfunctional cellular structures through autophagy plays a critical role in cellular homeostasis and environmental resilience.
Kathleen Hickey +6 more
doaj +1 more source
Macroautophagy in sporadic and the genetic form of Parkinson’s disease with the A53T a-synuclein mutation [PDF]
, 2012 The A53T mutation in the a-synuclein gene causes autosomal-dominant Lewy body Parkinson’s disease (PD). Cultured cell models have linked this mutation to increased cell macroautophagy, although evidence of enhanced macroautophagy in patients with this ...
Chegini, Fariba +5 more
core +2 more sources
A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
Nature Communications, 2017 Acetylation of Atg3 regulates lipidation of Atg8 and therefore autophagy, but the molecular mechanisms remain unclear. Here, Liet al. semi-synthesize diacetylated Atg3, allowing them to show that acetylated Atg3 enhances Atg8 lipidation by promoting ...
Yi-Tong Li +10 more
doaj +1 more source
TaBZR1 Directly Activates Autophagy‐Related (ATG) 8 to Promote Wheat Defence to Powdery Mildew
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2018-2020, April 2026.
Yamei Zhuang +13 more
wiley +1 more source
Pbs2 regulates late‐stage macroautophagy in Saccharomyces cerevisiae
Animal Models and Experimental MedicineAutophagy is crucial for maintaining cellular homeostasis and is linked to various diseases. In Saccharomyces cerevisiae, the Polymyxin B Sensitivity 2 (Pbs2) protein is a member of the mitogen‐activated protein kinase (MAPK) family and plays a role in ...
Jianing Song +8 more
doaj +1 more source
ATG8 delipidation is not universally critical for autophagy in plants
Nature CommunicationsIntracellular recycling via autophagy is governed by post-translational modifications of the autophagy-related (ATG) proteins. One notable example is ATG4-dependent delipidation of ATG8, a process that plays critical but distinct roles in autophagosome ...
Yong Zou +13 more
doaj +1 more source