Results 101 to 110 of about 18,950 (216)

Involvement of autophagy in the direct ER to vacuole protein trafficking route in plants [PDF]

, 2014
Trafficking of proteins from the endoplasmic reticulum (ER) to the vacuole is a fundamental process in plants, being involved both in vacuole biogenesis as well as with plant growth and response to environmental stresses. Although the canonical transport
Gad Galili, Simon Michaeli, Tamar Avin-Wittenberg   +2 more
core   +2 more sources

Anti‐Cancer Effect of a New 5‐FU Derivative Containing Triazole‐Bearing Mannose (5‐FUD‐MAN) Against Human Breast Cancer Cells Through LC3B‐Mediated Cell Death

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 4, April 2026.
The anticancer activity of 5‐FU modified with mannose containing 1,2,3‐triazole compound in MCF‐7 breast cancer cells were revealed in this study. While 5‐FU caused cytotoxicity in both cancerous and healthy cells, 5‐FUD‐Man showed selective cytotoxicity.
Ebru Şanci, Azada Aliyeva, Buket Bakan, Mustafa Özkaraca, Erkan Halay, Kadir Ay, Tamer Karayildirim, N. Ulku Karabay Yavasoglu   +7 more
wiley   +1 more source

Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo [PDF]

, 2018
Autophagy plays a very important role in numerous physiological and pathological events. However, it still remains unclear whether Atg7-induced autophagy is involved in the regulation of neural crest cell production.
A Kuma, AJ Chalpe, AM Lacosta, Andrea Münsterberg, B Levine, B Ravikumar, BK Hall, C Gao, C Zhuo, Chang Liang, D Henrique, DR Cordero, E Coucouvanis, En-ni Chen, G Juhasz, G Wang, G Wang, Guang Wang, IH Lee, J Cayuso, J Jang, J McCredie, JE Simkin, Jianxin Liang, L Hari, L Lamalice, L Pinsky, Lin-rui Gao, Liu Cao, M Komatsu, MA Mellen, Manli Chuai, ML Basch, MR Aburto, OO Oyedele, PJ Fraker, Q Yue, RA Schneider, RC Russell, S Somi, SC Chapman, SV Hegarty, TC Carter, TF Gale, WH Lu, X Qu, X Wu, X Yang, X Yang, Xuesong Yang, XY Wang, Y Liu, Yongping Bao, Z Jia   +53 more
core   +3 more sources

Crystal structures of Fsc1, a novel autophagy factor that mediates autophagosome–vacuole fusion in fission yeast

Acta Crystallographica Section D, Volume 82, Issue 4, Page 358-369, April 2026.
Crystal structures of the autophagy protein Fsc1 reveal conserved fasciclin features and a stable dimer interface that illuminate its possible role as a scaffold in autophagosome–vacuole membrane fusion.Fsc1 is a recently identified autophagy factor in the fission yeast Schizosaccharomyces pombe that is implicated in the autophagosome–vacuole fusion ...
Chidiogo Azuka, Jian Liu, Xiangshu Jin
wiley   +1 more source

Atg4 recycles inappropriately lipidated Atg8 to promote autophagosome biogenesis [PDF]

Autophagy, 2012
Atg8 is a ubiquitin-like protein required for autophagy in the budding yeast Saccharomyces cerevisiae. A ubiquitin-like system mediates the conjugation of the C terminus of Atg8 to the lipid phosphatidylethanolamine (PE), and this conjugate (Atg8-PE) plays a crucial role in autophagosome formation at the phagophore assembly site/pre-autophagosomal ...
Hitoshi, Nakatogawa, Junko, Ishii, Eri, Asai, Yoshinori, Ohsumi   +3 more
openaire   +2 more sources

Chloroplast damage induced by the inhibition of fatty acid synthesis triggers autophagy in chlamydomonas [PDF]

, 2018
Fatty acids are synthesized in the stroma of plant and algal chloroplasts by the fatty acid synthase complex. Newly synthesized fatty acids are then used to generate plastidial lipids that are essential for chloroplast structure and function.
Andrés Garrido, Ascensión, Crespo González, José Luis, Heredia Martínez, Luis G., Martínez Force, Enrique, Pérez Pérez, Maria Esther   +4 more
core   +1 more source

Autophagy‐Independent Function of ATG‐18 Is Essential for Gonadal Longevity in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 4, April 2026.
Neuronal and intestinal ATG‐18 promote longevity conferred by germline removal in C. elegans via non‐autophagic functions. In the intestine, ATG‐18 regulates lifespan through its interaction with the gluconeogenic enzyme PCK‐2. ABSTRACT Autophagy, a highly conserved cellular degradation process, plays essential roles in various physiological processes ...
Tatsuya Shioda, Ittetsu Takahashi, Makoto Horikawa, Taiichi Osumi, Takayuki Shima, Akiyo Yamauchi, Kayo Nakamura, Taeko Sasaki, Tatsuya Kaminishi, Harunori Yoshikawa, Miyuki Sato, Hidetaka Kosako, Tamotsu Yoshimori, Shuhei Nakamura   +13 more
wiley   +1 more source

ATG5 is essential for ATG8-dependent autophagy and mitochondrial homeostasis in Leishmania major [PDF]

, 2012
Macroautophagy has been shown to be important for the cellular remodelling required for Leishmania differentiation. We now demonstrate that L. major contains a functional ATG12-ATG5 conjugation system, which is required for ATG8-dependent autophagosome ...
A Garami, AD Uboldi, AM Silva, B Levine, Benjamin Cull, C Mammucari, C Osman, DC Rubinsztein, DJ Rigden, DJ Rigden, DL Sacks, DR Voelker, DW Hailey, EG Bligh, EL Axe, FF Hsu, GA McQuibban, GH Coombs, Graham H. Coombs, H Nakatogawa, H Weidberg, I Kim, I Tanida, JC Mottram, Jeremy C. Mottram, K Okamoto, K Wang, K Zhang, K Zhang, Kent L. Hill, LM Stephenson, M Graef, M Herman, N Mendl, P Codogno, PJ Myler, PW Denny, R Scherz-Shouval, R t'Kindt, R t'Kindt, R Zufferey, R Zunino, RA Gottlieb, RA Williams, RA Williams, RA Williams, RA Williams, RL Schweers, Roderick A. M. Williams, S Besteiro, S Pankiv, SA Tooze, T Hanada, T Kanki, T Shintani, Terry K. Smith, U Nair, V Soubannier, W Dowhan, Y Fujioka, Y Zhang, Z Yang   +61 more
core   +4 more sources

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum.

PLoS ONE, 2012
Autophagy is a membrane-mediated degradation process, which is governed by sequential functions of Atg proteins. Although Atg proteins are highly conserved in eukaryotes, protozoa possess only a partial set of Atg proteins.
Kei Kitamura, Chieko Kishi-Itakura, Takafumi Tsuboi, Shigeharu Sato, Shigeharu Sato, Kiyoshi Kita, Nobuo Ohta, Noboru Mizushima   +7 more
doaj   +1 more source