Results 91 to 100 of about 18,950 (216)
Coordination of Autophagosome–Lysosome Fusion by Atg8 Family Members [PDF]
Current Biology, 2018 Macroautophagy is a conserved intracellular lysosomal degradative pathway, vital for the maintenance of cellular homeostasis. It is characterized by double-membrane vesicles called autophagosomes, which sequester the cytoplasmic material destined for lysosomal turnover. In a final step, autophagosomes fuse with lysosomes to release their cargo into the
Kriegenburg, Franziska +2 more
openaire +3 more sources
HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa [PDF]
, 2018 The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing.
A Criollo +70 more
core +4 more sources
Molecular Plant Pathology, Volume 27, Issue 5, May 2026.SDE4250 suppressed 26S proteasome activity by targeting CsRPN10 and enhancing its degradation via the proteasome pathway. This impairment of proteasome function subsequently attenuates SA‐mediated defence responses, thereby increasing citrus susceptibility to promote CLas infection.
Yalin Mei +7 more
wiley +1 more source
Frontiers in Plant Science, 2023 Nutrient starvation-induced autophagy is a conserved process in eukaryotes. Plants defective in autophagy show hypersensitivity to carbon and nitrogen limitation.
Li-Yen Lin +6 more
doaj +1 more source
MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins [PDF]
, 2012 Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved catabolic process necessary for normal recycling of cellular constituents and for appropriate response to cellular stress.
Chiariello, Mario +8 more
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 5, Page 3426-3440, May 2026.ABSTRACT The plant endomembrane system and vesicle trafficking are central to plant immunity, mediating the targeted delivery and recycling of defence molecules during pathogen attack. Here, we investigated the functional role of soybean Vacuole Membrane Protein 1 (GmVMP1) in mediating resistance against soybean cyst nematode (SCN, Heterodera glycines).
Tracy E. Hawk +15 more
wiley +1 more source
Methods to Monitor and Quantify Autophagy in the Social Amoeba Dictyostelium discoideum [PDF]
, 2017 Autophagy is a eukaryotic catabolic pathway that degrades and recycles cellular components to maintain homeostasis. It can target protein aggregates, superfluous biomolecular complexes, dysfunctional and damaged organelles, as well as pathogenic ...
Cardenal-Muñoz, E. +5 more
core +3 more sources
Advanced Science, Volume 13, Issue 24, 27 April 2026.MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Huiqing Xia +11 more
wiley +1 more source
Mammalian ATG8 proteins maintain autophagosomal membrane integrity through ESCRTs
The EMBO Journal, 2023 AbstractThe canonical autophagy pathway in mammalian cells sequesters diverse cytoplasmic cargo within the double membrane autophagosomes that eventually convert into degradative compartments via fusion with endolysosomal intermediates. Here, we report that autophagosomal membranes show permeability in cells lacking principal ATG8 proteins (mATG8s) and
Ruheena Javed +18 more
openaire +4 more sources
Membrane morphology is actively transformed by covalent binding of the protein Atg8 to PE-lipids. [PDF]
PLoS ONE, 2014 Autophagy is a cellular degradation pathway involving the shape transformation of lipid bilayers. During the onset of autophagy, the water-soluble protein Atg8 binds covalently to phosphatdylethanolamines (PEs) in the membrane in an ubiquitin-like ...
Roland L Knorr +5 more
doaj +1 more source